Natural protein bioinspired materials for regeneration of hard tissues

Xu, Xinyuan; Chen, Xingyu; Li, Jianshu

doi:10.1039/d0tb00139b

Cited by 53 publications

(41 citation statements)

References 225 publications

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“…Inspiration from natural products has generated artificial products that can be adjusted and enhanced by chemical modification [ 43 ]. For example, a simple and feasible conjugation reaction catalyzed by EDC/NHS was used in this study to achieve the conjugate Da-g-Xan.…”

Section: Discussionmentioning

confidence: 99%

Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis

Huang

Jiang

Liu

et al. 2021

Bioactive Materials

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Herein, we report the synthesis of a biomimic hydrogel adhesive that addresses the poor healing of surgical anastomosis. Dopamine-conjugated xanthan gum (Da-g-Xan) is fabricated using deep insights into the molecular similarity between mussels' adhesive and dopamine as well as the structural similarity between barnacle cement proteins and xanthan gum. The hydrogel mimics marine animals’ adherence to wet tissue surfaces. Upon applying this adhesive to colonic anastomosis in a rat model, protective effects were shown by significantly improving the bursting pressure. Mechanistically, the architecture of Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds that allow the quick release of Da-g-Xan. The free Da-g-Xan can regulate the inflammatory status and induce type 2 macrophage polarization (M2) by specifically interacting with mannose receptors (CD206) revealed by RNA-sequencing and molecular binding assays. Consequently, an appropriate microenvironment for tissue healing is created by the secretion of chemokines and growth factors from M2 macrophages, strengthening the fibroblast migration and proliferation, collagen synthesis and epithelial vascularization. Overall, this study demonstrates an unprecedented strategy for generating an adhesive by synergistic mimicry inspired by two marine animals, and the results show that the Da-g-Xan adhesive augments native tissue regenerative responses, thus enabling enhanced recovery following surgical anastomosis.

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Section: Discussionmentioning

confidence: 99%

Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis

Huang

Jiang

Liu

et al. 2021

Bioactive Materials

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“…Scaffolds derived from these can be manufactured to simulate natural ECM and, when used with integration of growth factors or living cells, can offer osteoconductive and osteoinductive properties [160]. More recently, bioinspired proteins have gained attention as biomimetic scaffolds for hard tissue regeneration [161].…”

Section: Immune Reaction Transmission Of Infection (B) Natural Polymersmentioning

confidence: 99%

Biomimetic Aspects of Oral and Dentofacial Regeneration

et al. 2020

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Biomimetic materials for hard and soft tissues have advanced in the fields of tissue engineering and regenerative medicine in dentistry. To examine these recent advances, we searched Medline (OVID) with the key terms “biomimetics”, “biomaterials”, and “biomimicry” combined with MeSH terms for “dentistry” and limited the date of publication between 2010–2020. Over 500 articles were obtained under clinical trials, randomized clinical trials, metanalysis, and systematic reviews developed in the past 10 years in three major areas of dentistry: restorative, orofacial surgery, and periodontics. Clinical studies and systematic reviews along with hand-searched preclinical studies as potential therapies have been included. They support the proof-of-concept that novel treatments are in the pipeline towards ground-breaking clinical therapies for orofacial bone regeneration, tooth regeneration, repair of the oral mucosa, periodontal tissue engineering, and dental implants. Biomimicry enhances the clinical outcomes and calls for an interdisciplinary approach integrating medicine, bioengineering, biotechnology, and computational sciences to advance the current research to clinics. We conclude that dentistry has come a long way apropos of regenerative medicine; still, there are vast avenues to endeavour, seeking inspiration from other facets in biomedical research.

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“…Hence, IDPs and IDPPs make versatile building blocks in the design of supramolecular self‐assembling biomaterials with precise de novo control over architecture and functionality. [ 9–12 ] Interplay of inter‐ and intramolecular interactions between disordered building blocks and order‐promoting motifs has been harnessed for a variety of materials science applications [ 13 ] such as microstructured hydrogel fabrication, [ 14,15 ] templated biomineralization, [ 16 ] generation of artificial membraneless organelles with programmable cargo recruitment and release, [ 17 ] and formation of biologically derived and biologically degradable surfactants for drug delivery and catalysis. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

Application of Thermoresponsive Intrinsically Disordered Protein Polymers in Nanostructured and Microstructured Materials

Wang

Patkar

Kiick

2021

Macromolecular Bioscience

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Modulation of inter‐ and intramolecular interactions between bioinspired designer molecules can be harnessed for developing functional structures that mimic the complex hierarchical organization of multicomponent assemblies observed in nature. Furthermore, such multistimuli‐responsive molecules offer orthogonal tunability for generating versatile multifunctional platforms via independent biochemical and biophysical cues. In this review, the remarkable physicochemical and mechanical properties of genetically engineered protein polymers derived from intrinsically disordered proteins, specifically elastin and resilin, are discussed. This review highlights emerging technologies which use them as building blocks in the fabrication of highly programmable structured biomaterials for applications in delivery of biotherapeutic cargo and regenerative medicine.

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Natural protein bioinspired materials for regeneration of hard tissues

Abstract: This review describes the protein bioinspired materials for the repair of hard tissues such as enamel, dentin and bone.

Cited by 53 publications

References 225 publications

Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis

Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis

Biomimetic Aspects of Oral and Dentofacial Regeneration

Application of Thermoresponsive Intrinsically Disordered Protein Polymers in Nanostructured and Microstructured Materials

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