Tannins are the secondary metabolites of plants, and are polymers consisting mainly of glycosides, found in nature as hydrolysable tannins or condensed tannins, as well as a combination of them. In the European Horizon 2020-funded Stance4Health project, one of the objectives is to develop special tannin extracts (from chestnut wood, quebracho wood, oak wood, tara pods, Chinese gallnuts) with differential effects on the gut microbiota and human health, aiming for a personalized modulation of gut microbiota activity at the individual level.