Natural transmission of group B<i>Streptococcus</i>during delivery

Matorras, Roberto; García-Perea, Adela; Usandizaga, J. A.; Omeñaca, F

doi:10.1016/0020-7292(89)90302-0

Cited by 17 publications

(9 citation statements)

References 15 publications

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“…These observations were in accordance with a large study from Bengaluru and Maharashtra but were in contrast to the study from Oxfordshire, United Kingdom. 3,5,9 One important association found in the current study was the association of GBS carriage and duration of ruptured membranes for 10 hours or more. The duration reported in earlier studies was between 12 and 18 hours but, in our study, we found statistically significant association with 10 hours or more duration of ruptured membranes and GBS colonization (p-value = 0.002).…”

Section: Discussionmentioning

confidence: 51%

“…Around 68 of 110 women The strong evidence for the usefulness of the universal screening at 35 to 37 weeks of pregnancy to prevent GBS neonatal infection was mainly drawn from studies conducted in the United States. [2][3][4][5][6][7] However, GBS is present worldwide and the prevalence of GBS carriers varies in relation to the geographical area and/or a number of demographic factors. [8][9][10][11][12][13][14][15] In the present study, the prevalence of anogenital carriage of GBS was 12.15%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Patil¹,

Singla²,

Nagmoti³

2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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Objectives: Group B Streptococcus (GBS) has been recognized as the leading cause of serious neonatal infections through mother-fetal vertical transmission in the west, however, in India, its spectrum is largely under estimated. The present study was carried out to find the incidence of rectovaginal carriage of GBS in parturient women, association with risk factors in mother and to study the neonatal outcome. Materials and methods:A one year cross-sectional prospective study was carried out in 905 parturient women admitted at a tertiary care center meeting the selection criteria over a period of one year from June 2007 to May 2008. The inclusion criteria were all pregnant women admitted to the labor room after 35 ± 1 week of gestation. Rectal and vaginal swabs were taken and cultured on selective Todd-Hewitt broth medium followed by sub culture on blood agar and confirmation by Latex agglutination test from all the women meeting the inclusion criteria. The outcomes measured were the incidence, antenatal risk factors in mother and the neonatal outcome. Analysis was done using paired 't' test, chi-square test and a p-value of <0.05 was taken as statistically significant. Results:Incidence of group B Streptococcus (GBS) was 12.15% and detection rate was increased by 4.6% with the inclusion of rectal swabs for culture. GBS carriage was significantly increased with preterm birth (OR 8.3, 95% CI,1.1-15.5), premature rupture of membranes (OR 7.5, 95% CI, 1.1-13.4), prolonged duration of ruptured membranes more than 10 hours (OR 21, 95% CI,15.2-34.2) and intrapartum temperature more than 38°C(OR 3.1, 95% CI, 0.43-6.66). Birth weight less than 2.5 kg and neonatal intensive care admissions were significantly more (35.45%) in infants of GBS positive women. Conclusion:GBS colonization was more frequent in women with risk factors. GBS pick up rate was increased by the inclusion of both rectal and vaginal swabs.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Patil¹,

Singla²,

Nagmoti³

2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…The number of expected episodes of streptococcal sepsis with each strategy was calculated taking into account the following variables: the prevalence of maternal colonisation and of risk factors; the sensitivity and specificity of antenatal group B streptococcus cultures and of risk factors in predicting intrapartum maternal colonisation; the probability of receiving antibiotics during labour; their efficacy in preventing vertical transmission; the probability of vertical transmission; and the probability of sepsis in colonised babies 2–6,9,10,14–18,24,26–64 (Table 2).…”

Section: Methodsmentioning

confidence: 99%

Choosing a strategy to prevent neonatal early‐onset group B streptococcal sepsis: economic evaluation

Stan

Boulvain

Bovier

et al. 2001

BJOG

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Objective To determine the most appropriate strategy to prevent neonatal streptococcal sepsis in a setting with a low incidence of the disease.Design Decision analysis and economic evaluation.Setting Geneva University Hospitals, Switzerland.Population Pregnant women at 35-37 weeks of gestation and in labour.Methods Local data and data from the literature were used in a decision analysis to compare the current policy of antibiotic administration at Geneva University Hospitals with the recommended preventive strategies.Main outcome measures Number of episodes of sepsis averted; cost and number needed to treat to prevent one episode of sepsis; and proportion of women receiving antibiotics during labour.Results Compared with the current policy, the risk factors strategy would prevent 69 streptococcal sepsis per million deliveries and the screening strategy would prevent 102 cases of sepsis per million deliveries. Cost per averted sepsis case would be £60, 700 and £473, 600, respectively. The number needed to treat to prevent one sepsis would be 1087 with a risk factors strategy and 1029 with a screening strategy. Preventive strategies would increase the proportion of women receiving antibiotics during labour from 6% with the current policy, to 13.5% and 16.5% respectively.Conclusions Preventive strategies are more effective than the current policy, but imply increased hospital costs and a notable increase in the proportion of women receiving antibiotics during labour, which may be unjusti®ed in a low incidence setting.

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“…[87%] mothers, 35 [88%] pediatricians, and 30 [75%] obstetricians). However, only 17 (43%) obstetricians thought physicians should use this type of technique to help them decide the best way to treat their patients, com¬ pared with 73 (88%) mothers and 29 (73%) pediatri¬ cians.…”

Section: Resultsmentioning

confidence: 99%