Naturally‐occurring chronic renal disease in Australian cats: a prospective study of 184 cases

White, Joanna; Norris, Jacqueline M.; Baral, Randolph M.; Malík, Richard

doi:10.1111/j.1751-0813.2006.tb12796.x

Cited by 35 publications

(35 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results show that the median age of affected cats was 13 years old, whereas the median age of the healthy control group was 4 years old. This significant difference is consistent with previous studies that have shown CKD to be primarily an age‐related disease . According to the IRIS staging system, the severity of proteinuria indicates to a worse prognosis for the patient and this is consistent with the findings of our study in which an increase in proteinuria was paralleled by the progression of CKD.…”

Section: Discussionsupporting

confidence: 93%

Neutrophil Gelatinase‐Associated Lipocalin in Cats with Naturally Occurring Chronic Kidney Disease

Wang

Hsu

et al. 2016

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundNeutrophil gelatinase‐associated lipocalin (NGAL) is a biomarker for the early prediction of renal damage and the progression of chronic kidney disease (CKD) in humans and dogs.HypothesisNeutrophil gelatinase‐associated lipocalin also may play a role in the progression of CKD in cats.AnimalsEighty CKD and 18 control cats.MethodsCats were categorized into different stages according to the International Renal Interest Society (IRIS) staging system. Urine and plasma samples were collected and tested for NGAL concentrations using an in‐house sandwich ELISA system and urinary NGAL (uNGAL)‐to‐creatinine ratio (UNCR) was determined. Cats in which serum creatinine concentration increased by >0.5 mg/dL from baseline within 30 days were defined as exhibiting progression.ResultsThe urinary NGAL and UNCR of CKD cats were significantly higher than those of healthy cats (P < .05) and were highly correlated with serum creatinine concentration. The area under the receiver operating characteristic curve (AUROC) for uNGAL, when predicting the progression of CKD, was 0.71 and the best cutoff value was 2.06 ng/mL with a sensitivity of 76.9% and a specificity of 75%. The AUROC for UNCR when predicting the progression of CKD was 0.79 and the best cutoff value was 4.08 × 10−6 with a sensitivity of 76.9% and specificity of 79.2%. Cats with UNCR values higher than their cutoffs experienced significantly faster deterioration with a median of 19 days.ConclusionsBoth urinary NGAL and UNCR are useful markers for the prediction of CKD progression in cats.

show abstract

Section: Discussionsupporting

confidence: 93%

Neutrophil Gelatinase‐Associated Lipocalin in Cats with Naturally Occurring Chronic Kidney Disease

Wang

Hsu

et al. 2016

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…A study of age distribution in cats with chronic renal failure (CRF) found that most were less than 10 years old (37 %), between 10 and 15 years old (31 %), or older than 15 years of age (32 %) (Lulich et al 1992). In Australia, a study of 184 felines with CRF indicated that males with CRF had a median age of 12 years, whereas females with CRF had a median age of 15 years (White et al 2006). There was no association between age and oxidative stress parameters in the present study.…”

Section: Discussionmentioning

confidence: 98%

Changes in reduced glutathione, oxidized glutathione, and glutathione peroxidase in cats with naturally occurring chronic kidney disease

Piyarungsri

Pusoonthornthum

2016

Comp Clin Pathol

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is one of the most common diseases in geriatric cats. The objective of this study was to determine oxidative stress in CKD cats by measuring changes in reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx), and reduced glutathione to oxidized glutathione (GSH/GSSG) ratio in cats with naturally occurring chronic kidney disease (CKD). Thirteen clinically normal client-owned aged-matched cats and 23 naturally occurring CKD cats were included. Completed blood count, blood urea nitrogen, creatinine, GSH, GPx, GSSG, and GSH/GSSG ratio were measured on the first day of diagnosis. The results showed that CKD cats had significantly lower GSH, GPx, and GSH/GSSG ratio levels (2.77 ± 0.27 mM, 2.32 ± 0.40 nmol/min and 148.26 ± 34.19) than the clinically normal client-owned age-matched cats (4.23 ± 0.67 mM, 6.68 ± 0.79 nmol/min and 312.64 ± 76.80). The GSSG in the CKD cats (35.20 ± 4.37 μM) was significantly higher than in the clinically normal client-owned age-matched cats (19.66 ± 2.75 μM). The results indicated that cats with naturally occurring CKD experience oxidative stress.

show abstract

“…Tubulo-interstitial nephritis (TIN) is the most frequent histopathological finding in feline chronic kidney disease (CKD) (Jepson, 2016) and CKD is one of the most commonly diagnosed diseases in old cats, affecting ≥30-40% of individuals over 10 years of age (White et al, 2006;Marino et al, 2014). In most cats, CKD is also a progressive disease and can be accompanied by a wide range of clinical and pathological changes, but the underlying aetiology of CKD is often undiagnosed.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy

Luca

Crisi

Marcacci

et al. 2020

Veterinary Microbiology

View full text Add to dashboard Cite

A B S T R A C TFeline morbillivirus (FeMV) is an emerging morbillivirus first described in cats less than a decade ago. FeMV has been associated with chronic kidney disease of cats characterized by tubulointerstitial nephritis (TIN), although this aspect is still controversial and not demonstrated with certainty. To investigate FeMV prevalence and genomic characteristics, an epidemiological survey was conducted in a total number of 127 household cats originating from two Italian regions, Abruzzi and Emilia-Romagna. A total number of 69 cats originating from three feline colonies were also enrolled for the study. Correlation with TIN was investigated by employing a total number of 35 carcasses. Prevalence of FeMV RNA was higher in urine samples collected from cats of colonies (P = 31.8%, CI 95% 22.1-43.6) compared to household cats (P = 8.66%, CI 95% 4.9-14.9) and in young and middle-aged cats while prevalence of FeMV Abs was higher in old cats. Sequences obtained straight from infected biological samples, either partial or complete, cluster into two clades within FeMV genotype 1, distantly related to FeMV genotype 2. Immunohistochemistry analysis of kidney sections of FeMV RNA positive cats revealed immunoreactivity within epithelial cells of renal tubuli and inflammatory cells. However, statistically significant association between FeMV and renal damages, including TIN, was not demonstrated (p= 0.0695, Fisher exact test). By virus histochemistry performed with FeMV-negative feline tissues and a FeMV isolate, tropism for different cellular types such as inflammatory cells residing in blood vessels of kidney and brain, airway epithelial cells, alveolar macrophages and to a lesser extent, the central nervous system, was demonstrated. Additional studies are warranted in order to establish viral tropism and immune response during the early phases of infection and to disentangle the role of FeMV in co-infection processes.

show abstract

Naturally‐occurring chronic renal disease in Australian cats: a prospective study of 184 cases

Cited by 35 publications

References 21 publications

Neutrophil Gelatinase‐Associated Lipocalin in Cats with Naturally Occurring Chronic Kidney Disease

Neutrophil Gelatinase‐Associated Lipocalin in Cats with Naturally Occurring Chronic Kidney Disease

Changes in reduced glutathione, oxidized glutathione, and glutathione peroxidase in cats with naturally occurring chronic kidney disease

Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy

Contact Info

Product

Resources

About