Naturally occurring dibenzofurans. Part 3. On the structures of the rhodomyrtoxins

Designing inhibitors against fructose 1,6-bisphosphatase: Exploring natural products for novel inhibitor scaffolds

“…Next, we were faced with the challenge of functionalizing 14 with the appropriate acyl moiety. Attempts to introduce the isovaleryl group on the ring with isovaleryl chloride and tin (IV) chloride [25], as well as with isovaleric acid and boron trifluoride [22], proved unsuccessful. We reasoned that the isovaleryl portions could be strategically placed by means of a Friedel Crafts reaction to ultimately yield 15 .…”

Total synthesis of natural products containing benzofuran rings

“…It was selected 1,3,7,9-tetramethoxydibenzofuran 223, which is known to be synthesized from 1,3,5-trimethoxybenzene 221 in three steps. 230 At rst, they tried to synthesize 1,3,7,9-tetramethoxydibenzofuran 223. Iodination of 1,3,5-trimethoxybenzene 221 and Ullmann coupling gave 2,2 0 ,4,4 0 ,6,6 0 -hexamethoxybiphenyl 222.…”

Enrichment of dibenzofuran utilizing bacteria with high co-metabolic potential towards dibenzodioxin and other anellated aromatics

“…In order to evaluate the existence in nature of marginal activities for the catabolism of these cyclic biaryl ethers we employed the proved strategy of using structural analogues for basic studies ( [10] Dibenzofuran is the most simple cyclic biaryl ether and has been identified as a structural element in certain natural products [11][12][13][14][15]. Therefore in the present investigation it was used (i) as a structural analog for the enrichment of bacteria that oxidize dibenzodioxin or related compounds and (ii) as a model compound for elucidating mechanisms of cleavage of the biaryl ether bond.…”