Naturally Occurring Infectious Fibroma in the Domestic Rabbit

Pulley, LeaVonne; Shively, James N.

doi:10.1177/030098587301000604

Cited by 18 publications

(22 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The well developed ergastoplasm with much rough endoplasmic reticulum, and the abundance of intercellular fibrous material indicated the secretory activity of the tumor cells. This material contained large amounts of well differentiated collagen fibrils; the general morphological appearance of the tumor cells closely resembled that of fibroblasts in normal connective tissue [16,20] and in fibroblastic tumors [6,10,11,19,24]. Intercellular junctional complexes have been seen in other mesenchymal neoplasms [6,101 and also have been reported in a human cerebellar fibroma [13].…”

Section: Discussionmentioning

confidence: 94%

Central Neurofibromas in Two Dogs

1977

View full text Add to dashboard Cite

Abstract. Two dogs each had a fibrous tumor of the central nervous system. One tumor involved the spinal cord and ventral nerve root, and the other involved the midbrain and posterior brain stem. Both tumors had spindle-shaped cells arranged in rhythmic patterns. There was perivascular tumor cell infiltration in the adjacent parenchyma. The tumor cells strongly resembled fibroblasts and seemed to produce collagen. Because both tumors were near nerve roots and because their histological appearances were characteristic of nerve sheath tumors they were classified as central neurofibromas. A 3'h-year-old mixed breed dog had a 3-week history of progressive right forelimb lameness. The dog was bright and alert and walked with a crouched, hypometric gait in both front limbs. Postural reactions were depressed in both front limbs, especially the right. The segmental spinal myotatic reflexes were exaggerated in all limbs. The results of hematology, blood chemistry and cerebrospinal fluid examination were within normal limits. Myelography showed spinal cord enlargement between C6 and T1, which suggested there was an intradural space-occupying mass. At C7 the diameter of the cord was greatest and filling defects were noted dorsally and ventrally. The dog was killed and necropsied. Dog 2A 4-year-old female Toy poodle had a 5-week history of altered behavior and difficulty in seeing and prehending food. Two weeks before presentation she had been weak and incoordinated in all limbs for about 36 hours. She seemed slightly disoriented, often circled to the right and occasionally fell to the left. There was a depressed menace response by the left eye, considerable atrophy of the masseter muscle on the left and decreased sensation in the face on the same side. Postural reactions were uniformly depressed on the left side. 470

show abstract

Section: Discussionmentioning

confidence: 94%

Central Neurofibromas in Two Dogs

1977

View full text Add to dashboard Cite

show abstract

“…This correlates well with previous studies. 16,34 Epithelial tumors consisted largely of adenomas and only few carcinomas. To the authors' knowledge, apocrine carcinomas and meibomian adenomas have not previously been described.…”

Section: Discussionmentioning

confidence: 99%

“…34,45 Approximately 7 to 12 days after the infection, animals develop one or multiple firm nodules that spontaneously regress over the course of a few weeks. 33,34 In newborn, young juvenile, or immunosuppressed rabbits, the tumors may persist and metastasize, leading to the death of the animal. 16,33,34 Shope papilloma is also transmitted by biting arthropods, yet it is caused by a papovavirus.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

et al. 2007

View full text Add to dashboard Cite

Abstract. Over a 16-year period, 190 tumors and tumorlike lesions from 179 pet rabbits were submitted for histopathologic examination. A total of 23 different tumor types and 1 tumorlike lesion were diagnosed. The most common diagnoses were trichoblastoma, collagenous hamartoma, and Shope fibroma. Viral-induced tumors were Shope fibroma (19) and Shope papilloma (2). Common nonviral epithelial tumors included trichoblastoma (59), squamous cell carcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma (3). Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9), malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4). Malignant melanoma was diagnosed in 8 rabbits. Collagenous hamartomas were diagnosed in 26 rabbits. Mesenchymal proliferations occurred significantly more often in male rabbits than in females. Collagenous hamartomas and myxosarcomas occurred exclusively in male animals, and 3 rabbits had multiple collagenous hamartomas. Immunohistochemistry was applied in cases in which a definite diagnosis could not be reached on hematoxylin and eosin slides. Follow-up information was received in 19 cases. Carcinomas recurred (2 of 3) or metastasized (1 of 3), whereas sarcomas frequently recurred (7 of 12). One malignant melanoma (1 of 3) and one poorly differentiated round cell neoplasm recurred (1 of 1). This is the first comprehensive retrospective analysis on skin neoplasia in pet rabbits.

show abstract

“…A polyomavirus (papovaviridae) has been associated with cutaneous neoplasia in hamsters (Graffi et al 1968). Poxviruses cause proliferative skin lesions in squirrels (Hirth et al 1969, O'Connor et al 1980, rabbits (Shope 1932, Pulley & Shively 1973, and primates (Behbehani et al 1968). Retroviruses have been associated with fibromas and sarcomas in several species including initial studies have been unsuccessful.…”

Section: Discussionmentioning

confidence: 99%

Experimental transmission of green turtle fibropapillomatosis using cell-free tumor extracts

et al. 1995

View full text Add to dashboard Cite

Green turtle fibropapillomatosis (GTFP), characterized by multiple benign fibroepithelial tumors on the skin and eyes, has become a growing threat to green turtle Chelonja mydas populations worldwide. The cause of GTFP 1s unknown, but a viral etiology is suspected. This study investigated whether GTFP could be experimentally transmitted to young captive-reared green turtles using cell-free fibropapilloma extracts prepared from free-ranging turtles with spontaneous disease Turtles raised from eggs collected from 4 separate clutches in the wild were assigned to 4 expenmental groups and 1 control group. For each experiment a crude homogenate (33 % w/v) was prepared from fibropapillomas removed from a free-ranging turtle with spontaneous disease. The crude tumor homogenates were freeze-thawed and centrifuged to yield cell-free extracts that were used (both filtered and unaltered) for inoculation. Recipients were inoculated by intradermal injection or by scarification; control turtles were not treated but \yere housed with treated turtles. Fibropapillomas developed in all 12 turtles receiving 3 of the 4 tumor extracts, and were first detected between 15 and 43 wk post inoculation. Both filtered and unfiltered tumor extracts successfully induced tumor development. During the 10 and 12 mo monitoring periods. fibropapillomas did not develop in control turtles or in any turtles inoculated with the fourth tumor extract. Although 2 sets of experiments were performed 8 wk apart, most of the tumors in both sets became evident simultaneously after water temperatures rose Experimental tumors were h~stologically i n d~s -tinguishable from spontaneous fibropapillomas found In free-living turtles but lacked evidence of endoparasites. Scattered foci of epidermal degeneration were found in most sections of experimentally induced fibropapillomas and within some sections taken from donor turtles. Electron rnicroscopy revealed virus-like particles conforming in size, morphology, and intranuclear location with herpesvirus. Negativestaining electron microscopy of transmission-positive tumor extracts failed to demonstrate intact virus particles. This study demonstrates that the etiology of GTFP is an infectious filterable subcellular agent. The herpesvirus identified in this study is 1 possible candidate for the etiology of GTFP.

show abstract

Naturally Occurring Infectious Fibroma in the Domestic Rabbit

Cited by 18 publications

References 8 publications

Central Neurofibromas in Two Dogs

Central Neurofibromas in Two Dogs

Cutaneous Neoplasms in Pet Rabbits: A Retrospective Study

Experimental transmission of green turtle fibropapillomatosis using cell-free tumor extracts

Contact Info

Product

Resources

About