Naturally Occurring Organic Sulfur Compounds: An Example of a Multitasking Class of Phytochemicals in Anti-Cancer Research

Cerella, Claudia; Kelkel, Mareike; Viry, Elodie; Dicato, Mario; Jacob, Claus; Diederich, Marc

doi:10.5772/26003

Cited by 16 publications

(9 citation statements)

References 211 publications

(201 reference statements)

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“…Phenol and cysteine alanine are exist probably due to protein hydrolysis and biodegradation of phenolic compounds in intact garlic bulbs [20]. On the other hand, more than half of the alliin is lost during the dehydration [21] and alliinase presumably inactivate during heated at 65 ∘ C.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Main Bioactive Compounds and Antioxidant Activity from Garlic Water-soluble and Garlic Oil

Dewi

Kusnadi²,

Shih³

2017

KLS

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Garlic is a natural source which has abundant organosulfur constituents. Garlic is divided into water-soluble organosulfur constituents mainly SAC (S-allylcystein), NAC (N-acetylcysteine) and oil soluble organosulfur constituents such as DATS (diallyl trisulfide), DADS (diallyl disulfide), DAS (diallyl sulfide). The aim of this research was to compare the bioactive constituents and antioxidant activity between garlic water-soluble and garlic oil. Garlic water-soluble constituents were identified by Liquid Chromatography-Mass Spectrometry (LC-MS) and five constituents were found, namely N-acetylcysteine (NAC), cysteinyl-alanine, phenol-2-2-benzoxazolyl and two unknown constituents. The GC-MS chromatogram also showed three main constituents present in garlic oil as diallyldisulphide (DADS), diallyltrisulphide (DATS) and D-limonene. Interestingly, garlic water-soluble extract had higher antioxidant activity 70 % ± 0.02 % in comparison with garlic oil 58 % ± 0.07 %. This study conducts a novel preparation of garlic water-soluble for enhancing antioxidant properties on garlic novel preparation.

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Section: Discussionmentioning

confidence: 99%

“…Consequently, garlic water-soluble consist of NAC, a derivative of the amino acid L-cysteine which the highest antioxidant activity among the organosulfur compounds. NAC has a nucleophile and a -SH residue donor to counteract free radicals in cells leads to oxidative stress [2,7,11,21].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Main Bioactive Compounds and Antioxidant Activity from Garlic Water-soluble and Garlic Oil

Dewi

Kusnadi²,

Shih³

2017

KLS

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“…There is, throughout the literature, a tremendous body of evidence indicating a wide range of different properties for organosulfur compounds of garlic. 17 For instance, it has been shownthat diallyltrisulfide (DATS), a sulfur containing ingredient of garlic, induces apoptosis in human breast cancer cells (MCF-7) via ROS-mediated activation of JNK and AP-1. 7 Moreover, when orallyadministeredat a concentration of 1–2 mg/day, thrice/week for 13 weeks, by DASTS markedly suppressed prostate carcinoma and pulmonary metastasis in mouse animal model without any side effects.…”

Section: Discussionmentioning

confidence: 99%

Garlic (Allium sativum) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2

Farhadi

Jahanpour

Hazem

et al. 2015

J Dent Res Dent Clin Dent Prospects

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Background and aims. There is no report on the apoptotic impact of Allium sativum L.(Garlic) on the oral squamous cell carcinoma (KB); hence, this study was designed to survey the apoptotic effects of garlic fresh juice (GFJ) on the KB cells.Materials and methods. MTTassay (MicrocultureTetrazolium Assay) was carried out to evaluate the cytotoxicity of GFJ on KB cells. Furthermore, TUNEL(Terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling)and DNA fragmentation tests were performed to determine if GFJ is able to induce apoptosis in KB cells. Also a standard kit was used to assess caspase-3 activity in KB cells. Also western blotting was employed to evaluate the effect of GFJ on Bax:Bcl-2 ratio.Results. Significant cytotoxic effects were observed for the minimum used concentration (1μg/mL) as calculated to be 77.97±2.3% for 24 h and 818±3.1% for 36h of incubation (P < 0.001). Furthermore, TUNEL and DNA fragmentation tests corroborated the apoptosis inducing activity of GFJ. Consistently, after treating KB cells with GFJ(1μg/mL), caspase-3 activity and Bax:Bcl-2 ratio were raised by 7.3±0.6 and (P <0.001) folds, respectively.Conclusion. The results of this study advanced that GFJ induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio which could be attributed to its organo-sulfurcomponents.

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“…Thiosulfonates are allylsulfide compounds including allicin, diallyldisulfide, diallyltrisulfide, S-allylmercaptocysteine, S-allylcysteine [78]. This class of phytochemical organosulfurs is found essentially in garlic and other vegetables from Allium species.…”

Section: Thiosulfonatesmentioning

confidence: 99%

Nutritional Epigenetic Regulators in the Field of Cancer

Schnekenburger

Diederich

2015

Epigenetic Cancer Therapy

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Naturally Occurring Organic Sulfur Compounds: An Example of a Multitasking Class of Phytochemicals in Anti-Cancer Research

Cited by 16 publications

References 211 publications

Comparison of the Main Bioactive Compounds and Antioxidant Activity from Garlic Water-soluble and Garlic Oil

Comparison of the Main Bioactive Compounds and Antioxidant Activity from Garlic Water-soluble and Garlic Oil

Garlic (Allium sativum) Fresh Juice Induces Apoptosis in Human Oral Squamous Cell Carcinoma: The Involvement of Caspase-3, Bax and Bcl-2

Nutritional Epigenetic Regulators in the Field of Cancer

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