Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency

Abstract

Cancer treatment has raised many drugs and radiation therapies whose side-effects are visible. Ongoing research throughout the world for effective treatment mainly concentrates on methods either in the form of drugs or therapies against this lethal disease. However returning to ayurvedic roots enlightens the fact that nature has many efficient components with anti-cancerous, anti-proliferating and anti-angiogenesis effects. Evidences confirm the participation of plants extracts in synthesizing many medicines against already existing and even emerging diseases. Structure activity relationship (SAR) studies and structural modifications are helping in observing the basis of compounds characteristics to exhibit inhibitor’s nature against carcinogenic agents by modifying parent compounds for creating an improved and potent compound. Many components are under clinical trials but most of them still need attention. In this review an attempt has been made to focus on the natural components gifted by nature and even included in our diet with their structures and sources that could be supportive in designing drug either by computational methods or by experimental methods.

Biosurfactants Produced by Marine Microorganisms with Therapeutic Applications

“…In this sense, the search and development of new anti-cancer drugs that can overcome the multi-drug resistance of cancer cells remains a great challenge. Currently, many anti-cancer drugs used in clinical practice are natural products or derivatives thereof [ 46 , 47 , 48 , 49 ]. For that reason, it is likely that the continued and systematic exploration of natural sources, such as the marine microbiota, will lead to different and unforeseen compounds with interesting biological activities, including anti-cancer activity [ 50 , 51 ].…”

Pseudoalteromonas haloplanktis TAC125 produces 4-hydroxybenzoic acid that induces pyroptosis in human A459 lung adenocarcinoma cells

“…Many of the anticancer drugs used in clinical practice today are natural products or derivatives thereof 4 and the continued and systematic exploration of natural sources, such as marine microbiota, is expected to lead to the discovery of different and unforeseen compounds with interesting biological activities, including anticancer activity 5 . Marine bacteria have proven to be a unique and promising source of biologically active natural products 6 .…”

Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin

“…The reported anticancer activities of Resv are mediated through the modulation of several cell signaling molecules that regulate cell cycle progression, proliferation, apoptosis, invasion, metastasis, and angiogenesis of tumor cells. Although not fully understood, most of the activities of Resv are due to the presence of a phenol and m-hydroquinone moieties, especially the 4-hydroxyl group of the phenol ring which has been attributed with scavenging of free radicals, inhibition of proliferation, and genotoxic activity [ 2 , 3 , 4 , 5 ]. Resv can sensitize resistant cells to chemotherapeutic agents, including CDDP, by overcoming one or more mechanisms of chemoresistance [ 6 , 7 ].…”