Nature of the heterozygote blood catalase in a hypocatalasemic mouse mutant

Feinstein, Robert N.; Braun, Joann T.; Howard, Judith B.

doi:10.1007/bf00485182

Cited by 17 publications

(3 citation statements)

References 4 publications

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“…245 at 48 C, the catalase variant is inactivated completely under these conditions. Here a 50~o inactivation after 10 min occurs already at 44 C (Feinstein et al, 1968a).…”

Section: Introductionmentioning

confidence: 98%

Activity and stability of catalase in blood and tissues of normal and acatalasemic mice

1968

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Catalase activity in blood, liver, and kidney of a mutant strain Cs b has been found to be decreased as compared to the level in normal mice. However, the extent of the reduction largely depends on the conditions used for activity determination, in particular, temperature and duration of the incubation period. In liver, this effect is most pronounced, the observed activity in mutants varying between 21 and 85% of the normal level This dependence on the assay conditions is mainly due to the unusual heat lability of the variant enzyme, which undergoes rapid inactivation when incubated at 37 C.

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“…245 at 48 C, the catalase variant is inactivated completely under these conditions. Here a 50~o inactivation after 10 min occurs already at 44 C (Feinstein et al, 1968a).…”

Section: Introductionmentioning

confidence: 98%

Activity and stability of catalase in blood and tissues of normal and acatalasemic mice

1968

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“…We have been maintaining a hypocatalasemic mouse (C b s ) strain, which is a radiation-induced mutant of the C3H/ He mouse. Compared with the parent, this mouse strain has a decreased catalase activity in most solid tissues and especially in the blood whereas superoxide dismutase (SOD) activity is elevated [8][9][10] . Shaffer et al reported that the hypocatalasemic state in C b s is not due to alteration within the catalase structural gene or the level of gene transcription or mRNA stability, but rather to the level of mRNA translation and/or catalase protein turnover 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Tumors in Hypocatalasemic C3H/ C<sup>b</sup><sub>s</sub> /Gen and C3H Mice

et al. 2004

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Hypocatalasemic mice (C b s ) were examined for their life span and compared to C3H mice with reference to oxidase enzyme activity and spontaneous tumor development. N 1 -methylnicotinamice oxidase, xanthine oxidase (XO), xanthine dehydrogenase (XDH), and XO+XDH activities in 8 week-old male C b s mice were decreased as compared to the C3H counterparts. On the other hand, benzaldehyde oxidase in both sexes and xanthine dehydrogenase activity in females were significantly elevated as compared to the C3H. The total tumor incidence, number of tumors per mouse, liver tumors, and other tumor induction were significantly greater in as compared with until 499 days group in both sexes (P<0.01). The total incidence of tumors and incidence of liver tumors were not significantly different between the two strains in both sexes. The number of tumors per animal in C3H females and incidence of sarcoma in both sexes were significantly decreased as compared with the C b s case but the numbers of liver tumor per animal and ovarian tumors were significantly greater. (J Toxicol Pathol 2004; 17: 25-30)

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“…In 1964, Feinstein [7][8][9][10] has succeeded in getting acatalasémie mouse mutant by irradiation, then catalase activity was 2.5% of normal level. This residual catalase activity was less resistant to heat than normal mouse catalase, it was presumed that the residual catalase should be different from normal catalase as to its molecular structure.…”

mentioning

confidence: 99%

Catalase Activity of Immature and Mature Red Cells from Acatalasemic Mouse Mutant

Ogata¹,

Inoue²,

Tomokuni³

et al. 1970

Acta Haematol

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Nature of the heterozygote blood catalase in a hypocatalasemic mouse mutant

Cited by 17 publications

References 4 publications

Activity and stability of catalase in blood and tissues of normal and acatalasemic mice

Activity and stability of catalase in blood and tissues of normal and acatalasemic mice

Spontaneous Tumors in Hypocatalasemic C3H/ C<sup>b</sup><sub>s</sub> /Gen and C3H Mice

Catalase Activity of Immature and Mature Red Cells from Acatalasemic Mouse Mutant

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