Nausea and vomiting after laparoscopic surgery: a comparison of propofol and thiopentone/halothane anaesthesia

Klockgether-Radke, A.; Piorek, V.; Crozier, T. A.; Kettler, D.

doi:10.1097/00003643-199601000-00002

Cited by 29 publications

(20 citation statements)

References 20 publications

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“…Os resultados obtidos nesta pesquisa demonstram que o propofol utilizado para a indução e manutenção da anestesia, assim como a associação do propofol com a dexametasona, preveniram o aparecimento de náusea e vômito no pós-operatório de laparoscopia ginecológica. , anesthetic technique [7][8][9] and anesthetic drugs 10,11 . Young, healthy females submitted to gynecological laparoscopy are a group at increased risk for emetic symptoms 12 .…”

Section: Discussionunclassified

“…), propofol em infusão contínua para indução e manutenção da anestesia Há etiologia multifatorial colaborando para seu aparecimento, como, por exemplo, a técnica cirúrgica 3,4 , o sexo, a idade, o peso 5,6 , a técnica anestésica [7][8][9] e as drogas utilizadas em anestesia 10,11 . Pacientes do sexo feminino, jovens, saudá-veis, submetidas a procedimentos laparoscópicos ginecoló-gicos constituem um grupo com risco adicional de sintomas eméticos 12 .…”

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Eficácia do propofol e da associação de propofol e dexametasona no controle de náusea e vômito no pós-operatório de laparoscopia ginecológica

Ganem

Fukushima

Silva

et al. 2002

Rev. Bras. Anestesiol.

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Section: Discussionunclassified

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Eficácia do propofol e da associação de propofol e dexametasona no controle de náusea e vômito no pós-operatório de laparoscopia ginecológica

Ganem

Fukushima

Silva

et al. 2002

Rev. Bras. Anestesiol.

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“…Propofol rapidly and reliably induces anesthesia (Tagliente, 1997), is believed by some to reduce postoperative nausea and vomiting when used as both an induction and maintenance agent (Borgeat, WilderSmith, Saiah, & Rifat, 1992;Gan, Ginsberg, Grant, & Glass, 1996;Hamunen, Vaalamo, & Mauneksela, 1997;Klockgether-Radke, Piorek, Crozier, & Kettler, 1996;Myles, Hendrata, Bennett, Langley, & Buckland, 1996;Sung et al, 1991) but that result is controversial (Zestos et al, 1997). Propofol may interact with droperidol to increase nausea (Wagner, Berman, Devitt, & O'Hara, 1994).…”

Section: Problem Of Reducing Costsmentioning

confidence: 99%

Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol

Killpack¹

1999

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Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. The modern anesthesia provider must consider drug costs as important as benefits and risks when choosing which drug to use in an anesthetic. Thiopental has been the gold standard for an IV induction drug although propofol shows a better recovery profile with less post-operative nausea and vomiting, but at a higher cost. We attempted to determine if a 1:1 volume mixture of thiopental and propofol would show a similar recovery profile compared to propofol alone, but at a lower cost. This study examined the records of 212 surgery patients receiving propofol (n=82) or a 1:1 mixture (n=130) for demographic, peri-operative, PACU recovery, anti-emetic use, and cost data. We found that the propofol group had significantly more females, postoperative anti-emetic use, and induction drug costs, while the 1:1 mixture group had significantly longer surgery and anesthesia times. Mean post-operative anti-emetic drug costs were statistically significant (P<0.05) at $3.15 for the propofol group and $1.08 for the 1:1 mixture group. The mean cost of induction for the propofol group was $27.31 and $14.31 for the 1:1 mixture group, a statistically significant (P<0.05) difference of $13.09. The average recovery time for the propofol group was 134 minutes and cost $1205.37, and for the 1:1 mixture group 147 minutes and cost $1320.03. Thus, the difference in PACU charges was $114.66. This research suggests that the 1:1 mixture of thiopental and propofol produced a similar recovery profile to propofol alone, but at a lower direct cost. This study supported previous work, and recommends that further research be done to confirm its findings. ix ACKNOWLEDGEMENT SUBJECT TERMS

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“…Wie die weitere Analyse unserer Daten zeigt, korreliert die Nebenwirkungsrate sehr stark mit der Anästhesiezeit, die bei den standardisierten Operationen durch zwei Belegärzte überdurchschnittlich kurz ausfiel. Die Bedeutung der Anästhesiezeit wird auch in der Literatur betont [2,22,37].…”

Section: Verzicht Auf Lachgasunclassified

“…Für das antidopaminerg, antiserotonerg und antihistaminerg wirksame Droperidol ist dies gut belegt [21,25,27,33,35]. Unsere Ergebnisse bestätigen im Hinblick auf das Propofol Daten aus der jüngeren Literatur, die seine antiemetische Wirkung über die Modulierung subkortikaler Strukturen erklären [6,9,11,14,15,22,23,28]. Als vagotone Substanz, die gerade in den Kernen des hö-heren Gleichgewichtszentrums nicht zu einer Reduzierung des Glukosestoffwechsels führt, muß sie bei Nausea aus vagotoner Ursache oder durch Vestibularisaktivierung versagen [9].…”

Section: Verzicht Auf Lachgasunclassified

Propofol und postoperative Übelkeit und/oder Erbrechen

et al. 1997

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We found that the antiemetic effect of propofol was considerable in the early postoperative period. The higher cost of propofol as compared to other induction agents can be covered by not using nitrous oxide for maintenance of anaesthesia and by the decreased need for antiemetic drugs postoperatively. According to the calculations of our clinical pharmacy, the costs of the propofol infusion regimen exceeded those of balanced anaesthesia by 8.50 DM/h; the need for antiemetics was one-half that of the non-propofol group. Considering a cost of 16 DM for cleaning the bed after vomiting, improvement of the patient's condition during the postoperative period can be achieved without additional expense.

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Nausea and vomiting after laparoscopic surgery: a comparison of propofol and thiopentone/halothane anaesthesia

Cited by 29 publications

References 20 publications

Eficácia do propofol e da associação de propofol e dexametasona no controle de náusea e vômito no pós-operatório de laparoscopia ginecológica

Eficácia do propofol e da associação de propofol e dexametasona no controle de náusea e vômito no pós-operatório de laparoscopia ginecológica

Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol

Propofol und postoperative Übelkeit und/oder Erbrechen

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