Abstract. Precision of ball screw had a great impact on the positioning accuracy of NC positioning platform. The lead error and backlash of ball screw, which could be accurately measured by laser interferometer, were two key factors affecting the positioning accuracy of NC positioning platform. By setting the compensation data in the numerical control system, significant improvement of the positioning accuracy of NC positioning platform could be achieved. A method for measuring lead error and backlash of ball screw by laser interferometer was introduced and another method for calculating compensation data basing on the results of measurement was putted forward. Experiments were carried out on a multi-mode industrial CT scanning platform to verify these two methods. And the positioning accuracy of multi-mode industrial CT scanning platform was advanced obviously by compensating ball screw lead error and backlash with the compensation data measuring by laser interferometer.