In this paper, a fault tolerant control method based on the parametric estimation is presented and applied to the air path system of a diesel engine. This method uses directly the results of a parametric estimation of the system which is nonlinear and whose state variables and parameters are strongly coupled. Our goal is to adapt an Unconstrained Nonlinear Continuous-time Generalized Predictive Control (NCGPC) after detecting clearly, through a parametric variation, a fault occurred on a nonlinear model of Turbocharged Diesel Engine (TDE) published in the literature. Likewise, we will build a control strategy called Fault Tolerant Control (FTC) with which all detected dysfunctions and parametric variations will be taken into account.I.