Nd:YAG surgical laser effects in canine prostate tissue: temperature and damage distribution

Nimwegen, S.A. van; L’Eplattenier, Henry; Rem, Alex I.; Lugt, Jaco J. Van der; Kirpensteijn, Jolle

doi:10.1088/0031-9155/54/1/003

Cited by 49 publications

(33 citation statements)

References 51 publications

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“…More recently, thermocouples were used to mea-sure temperatures of laser-irradiated prostate tissue. 9 Another single-point method for measuring temperature is to focus thermal emission onto a mercury cadmium telluride detector. 10 However, single-point analyses cannot provide complete twodimensional descriptions of heat distribution within a tissue or cell layer and computational models are used to compensate for this inadequacy.…”

Section: Introductionmentioning

confidence: 99%

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Denton¹,

Noojin²,

Foltz³

et al. 2011

J. Biomed. Opt.

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Abstract. We measured threshold temperatures for cell death resulting from short (0.1-1.0 s) 514-nm laser exposures using an in vitro retinal model. Real-time thermal imaging at sub-cellular resolution provides temperature information that is spatially correlated with cells at the boundary of cell death, as indicate by post-exposure fluorescence images. Our measurements indicate markedly similar temperatures, not only around individual boundaries (single exposure), but among all exposures of the same duration in a laser irradiance-independent fashion. Two different methods yield similar threshold temperatures with low variance. Considering the experimental uncertainties associated with the thermal camera, an average peak temperature of 53 ± 2• C is found for laser exposures of 0.1, 0.25, and 1.0 s. Additionally, we find a linear relationship between laser exposure duration and time-averaged integrated temperature. The mean thermal profiles for cells at the boundary of death were assessed using the Arrhenius rate law using parameter sets (frequency factor and energy of activation) found in three different articles. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Denton¹,

Noojin²,

Foltz³

et al. 2011

J. Biomed. Opt.

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“…In this study we wanted to use the heating time as the only adjustable parameter while imposing a minimal tumour temperature in steady state. Based on previous studies [19,20,24,38], we assumed the minimal tumour temperature of 50 C during steady state. This was achieved by adjusting the laser irradiance.…”

Section: Dosimetric Planningmentioning

confidence: 99%

“…Many researchers have been utilising temperature thresholds to predict lesion size and to define thermal injury [9][10][11][12][13][14][15]. The most common temperature thresholds assigned are 43 C, 48 C, 50 C, and 60 C [16][17][18][19][20][21][22][23][24]. In theory, thermal damage can occur at any temperature above 43 C as long as the heating time is long enough.…”

Section: Introductionmentioning

confidence: 99%

Development of a computational simulation tool to design a protocol for treating prostate tumours using transurethral laser photothermal therapy

Manuchehrabadi

Zhu

2014

International Journal of Hyperthermia

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Heating time to achieve 100% damage to the tumour was identified to be approximately 630 s when using a laser irradiance of 7 W/cm2 incident on the prostatic urethral surface. Parametric studies were conducted to show how the local blood perfusion rate and urethral surface cooling affect the heating time to achieve the same thermal dosage. The heating time was shorter when cooling at the urethra was not applied and/or with heat-induced vasculature damage. The identified treatment protocols were acceptable since the calculated percentages of the damaged healthy tissue volume to the healthy prostatic volume were approximately 2%, less than the threshold of 5%. The approach and results from this study can be used to design individualised treatment protocols for patients suffering from prostatic cancer.

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“…This phenomenon has been investigated on thermocouples, where the artifact is caused by the metallic wires which constitute this kind of transducer. These studies show that the artifact is almost instantaneous, whereas a longer response time describes the increment actually caused by the temperature increase of surrounding tissue [11][12][13]. The marked differences between the abovementioned response times of these two contributions allow estimating and correcting the artifact: the correction employs the subtraction of the sudden temperature increase or decrease, which takes place when the laser is turned on or turned off, respectively.…”

Section: A Fiber Bragg Grating Sensormentioning

confidence: 99%

Development and characterization of a Fibre Bragg Grating temperature probe for medical Laser Ablation therapy

Polito

Schena

Saccomandi

et al. 2014

IEEE SENSORS 2014 Proceedings

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Temperature monitoring in tissue undergoing Laser Ablation (LA) is particularly beneficial to optimize therapy outcomes. During last decades several approaches have been proposed to perform thermometry during thermal ablation. Among others, Fiber Bragg Grating (FBG) sensors show valuable characteristics for such measurement, but their sensitivity to strain entails measurement error for patient respiratory movements.In this work two needle-like probes were developed using two different procedures to encapsulate an FBG into a surgical needle, aiming to allow safe insertion into the patient tissue and to neglect mechanical disturbance due to tissue movements occurring during breathing. The static calibration of the two probes has been carried out in a wide range of temperature (i.e., from 18 °C up to 100 °C), and their response time has been estimated. The calibration curves of the two probes show good linearity and a different sensitivity, and their response time is fast enough to meet the criteria set for temperature monitoring during LA.Since the metallic needle entails a measurement error, called artifact, due to the direct absorption of the laser radiation, the two abovementioned probes have been employed during LA on ex vivo liver. Then, their measurements have been compared to the measurement provided by an FBG without needle, which does not experience artifacts.The good results in terms of both static and dynamic properties of the two probes encourage to perform further analysis regarding the amplitude of the artifacts due to the direct absorption of the metallic needle and regarding the capability of the probes to neglect mechanical disturbance.

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Nd:YAG surgical laser effects in canine prostate tissue: temperature and damage distribution

Cited by 49 publications

References 51 publications

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Spatially correlated microthermography maps threshold temperature in laser-induced damage

Development of a computational simulation tool to design a protocol for treating prostate tumours using transurethral laser photothermal therapy

Development and characterization of a Fibre Bragg Grating temperature probe for medical Laser Ablation therapy

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