Near-Complete Genome Sequences of Streptomyces sp. Strains AC1-42T and AC1-42W, Isolated from Bat Guano from Cabalyorisa Cave, Mabini, Pangasinan, Philippines

León, Marian; Park, A-young; Montecillo, Andrew D.; Siringan, Maria Auxilia T.; Rosana, Albert Remus R.; Kim, Song‐Gun

doi:10.1128/mra.00904-18

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…[15,21], mycoplasmas [22,23], Pasteurella multocida [24], Rickettsia [18], Staphylococcus nepalensis [25], or Streptomyces sp. [26]. Antibiotic-resistant bacteria from bat faecal microbiome was studied in Myotis myotis and Rhinolophus hipposideros in Slovakia [27].…”

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confidence: 99%

Nontuberculous Mycobacteria Prevalence in Bats’ Guano from Caves and Attics of Buildings Studied by Culture and qPCR Examinations

et al. 2021

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A total of 281 guano samples were collected from caves (N = 181) in eight European countries (Bulgaria, Czech Republic, France, Hungary, Italy, Romania, Slovakia and Slovenia) and attics in the Czech R. (N = 100). The correlation of detection of mycobacteria between Ziehl–Neelsen (ZN) microscopy and culture examination and qPCR was strong. ZN microscopy was positive in guano from caves (58.6%) more than double than positivity in guano from attics (21.0%; p < 0.01). From 89 mycobacterial isolates (73 isolates from cave guano and 16 isolates from attics’ guano), 68 (76.4%) isolates of 19 sp., ssp. and complex were identified as members of three Groups (M. fortuitum, M.chelonae, and M. mucogenicum) and four complexes (M. avium, M. terrae, M.vaccae, and M.smegmatis). A total of 20 isolates (22.5%) belonged to risk group 1 (environmental saprophytes), 48 isolates (53.9%) belonged to risk group 2 (potential pathogens), and none of the isolates belonged to risk group 3 (obligatory pathogens). When comparing bat guano collected from caves and attics, differences (p < 0.01; Mann–Whitney test) were observed for the electrical conductivity, total carbon, total organic, and total inorganic carbon. No difference (p > 0.05; Mann–Whitney test) was found for pH and oxidation-reduction potential parameters.

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Section: Introductionmentioning

confidence: 99%

Nontuberculous Mycobacteria Prevalence in Bats’ Guano from Caves and Attics of Buildings Studied by Culture and qPCR Examinations

et al. 2021

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“…Continuous investigation of additional MOD-ACTINO is needed for the search for novel and effective secondary metabolites. In the Philippines, numerous studies have also been conducted in screening for actinomycetes with bioactive compounds in soil (Raymundo et al 1987), mollusks (Lin et al 2014), marine (Sabido et al 2020), bat caves (de Leon et al 2018), and urban green space (Daquioag and Penuliar 2021) environments. Despite the efforts of studying antibiotic-producing Streptomyces species in different environments, poorly explored habitats such as volcanic soils have not yet been widely investigated in the Philippines.…”

Section: Introductionmentioning

confidence: 99%

Genomic Insights into the Antimicrobial and Anticancer Potential of Streptomyces sp. A1-08 Isolated from Volcanic Soils of Mount Mayon, Philippines

Oliveros¹,

Rosana²,

Montecillo³

et al. 2021

Philipp J Sci

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Antimicrobial resistance (AMR) poses a global and developmental threat to humanity. The rapid emergence and spread of drug-resistant pathogens resulted in the ineffective use of currently available antibiotics. Therefore, there is a need to continue searching for additional sources of antibiotics, such as actinomycetes, which can potentially harbor unique and effective secondary metabolites. Furthermore, it is interesting to consider poorly explored environments like volcanoes, which can be potential sources of drug leads for medically important natural products. This study reports the antimicrobial activity of actinomycetes isolated from volcanic soil samples collected from Mount Mayon, Albay, Philippines. A total of 13 out of 30 morphologically distinct actinomycete isolates showed antagonistic activity against test microorganisms. Isolate A1-08, the focus of the study, exhibited a wide spectrum of antimicrobial activity against Salmonella enterica, Klebsiella pneumoniae, Staphylococcus aureus, methicillin-resistant S. aureus(MRSA), Candida albicans, Aspergillus niger, and Fusarium sp. Moreover, A1-08 was found to have anti-methicillin resistant S. aureus (MIC = 2.50 mg/mL) and anticancer activity against human colorectal cancer (HCT116) cell line (IC50 = 21.54 μg/mL). Whole-genome sequence-based phylogenetic analysis supported a novel species of Streptomyces closely related to S. olivaceus NRRL B-3009. A total of 48 biosynthetic gene clusters (BGCs) were identified that may be responsible for the biosynthesis of known and potentially novel secondary metabolites. This study concludes that Streptomyces sp. A1-08, a potentially novel species, is a good candidate to produce broad-spectrum antibiotics with anti-MRSA and anti-cancer activities and possibly novel secondary bioactive metabolites of medical and pharmaceutical importance.

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Culture collections and herbaria: Diverse roles in mycological research in the Philippines

León¹,

Siringan²

2023

Mycology in the Tropics

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Near-Complete Genome Sequences of Streptomyces sp. Strains AC1-42T and AC1-42W, Isolated from Bat Guano from Cabalyorisa Cave, Mabini, Pangasinan, Philippines

Abstract: Streptomyces sp. strains AC1-42T and AC1-42W, isolated from bat guano from Cabalyorisa Cave, Mabini, Pangasinan, Philippines, are active against Bacillus subtilis subsp. subtilis KCTC 3135T.

Cited by 3 publications

References 12 publications

Nontuberculous Mycobacteria Prevalence in Bats’ Guano from Caves and Attics of Buildings Studied by Culture and qPCR Examinations

Nontuberculous Mycobacteria Prevalence in Bats’ Guano from Caves and Attics of Buildings Studied by Culture and qPCR Examinations

Genomic Insights into the Antimicrobial and Anticancer Potential of Streptomyces sp. A1-08 Isolated from Volcanic Soils of Mount Mayon, Philippines

Culture collections and herbaria: Diverse roles in mycological research in the Philippines

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