Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

Zhong, Huiling; Huang, Jun; Luo, Moucheng; Fang, Yifei; Zeng, Xinchen; Wu, Jun; Du, Jianhang

doi:10.1007/s12274-022-4813-5

Cited by 36 publications

(24 citation statements)

References 47 publications

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Section: Preparation Methodsmentioning

confidence: 99%

“…To resolve this issue, a novel wound dressing has been developed using near-field electrospinning (NFES) to create a PCL fiber network combined with modified gelatin with methacrylic anhydride (GelMA) hydrogel to promote angiogenesis and reepithelialization of the diabetic wound. [54] The dressing incorporates the slow-release angiogenic and antioxidant drug deferoxamine (DFO) within the GelMA hydrogel. Cell adhesion experiments revealed that cells could attach to the surface network of PCL fibers and grow along their direction, indicating effective regulation of cell behavior through the physical structure of the dressing.…”

Section: Polycaprolactone-based Hydrogelmentioning

confidence: 99%

“…The absence of adequate blood vessels and the development of tissue necrosis due to the prolonged accumulation of free radicals pose a significant challenge to the healing of DFU. To resolve this issue, a novel wound dressing has been developed using near‐field electrospinning (NFES) to create a PCL fiber network combined with modified gelatin with methacrylic anhydride (GelMA) hydrogel to promote angiogenesis and re‐epithelialization of the diabetic wound [54] . The dressing incorporates the slow‐release angiogenic and antioxidant drug deferoxamine (DFO) within the GelMA hydrogel.…”

Section: Hydrogels As Wound Dressing For Diabetic Foot Ulcersmentioning

confidence: 99%

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Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Ko¹,

Liao

2023

BMEMat

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Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings are three‐dimensional networks of hydrophilic polymers that can absorb and retain large amounts of water, and have been shown to possess excellent biocompatibility, low toxicity, and excellent fluid handling properties. In addition, hydrogels create a moist wound environment that promotes wound healing by supporting cell proliferation, migration, and angiogenesis. Hydrogels, therefore, have emerged as promising wound dressings for promoting DFU healing. In this review, we attempt to chart the landscape of the emerging field of hydrogel as wound dressing for DFU treatment. We will explicitly review the assorted preparation methods for DFU hydrogels as well as a detailed discussion of various types of hydrogels deployed for DFU study. We also crystallize key findings, identify remaining challenges, and present an outlook on the future development of this enticing field.

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Section: Preparation Methodsmentioning

confidence: 99%

Section: Polycaprolactone-based Hydrogelmentioning

confidence: 99%

Section: Hydrogels As Wound Dressing For Diabetic Foot Ulcersmentioning

confidence: 99%

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Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Ko¹,

Liao

2023

BMEMat

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“…The detection of • OH was carried out by referring to the methods in the literature. 10,11,20,28 Likewise, we used 5,5-dimethyl-1-pyrroline N-oxide (DMPO) as the spin trapping agent and electron paramagnetic resonance (EPR) for the determination of • OH.…”

Section: Detection Of • Ohmentioning

confidence: 99%

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

Tan,

Zeng,

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote diabetic wound healing is still one of the toughest challenges in the medical field. Here, we constructed a new double-layer hydrogel to effectively regulate reactive oxygen species (ROS) on the wound and promote diabetic wound healing. The inner layer contains glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), and poly(β-cyclodextrin) (Pβ-CD), which is used to generate hydroxyl radicals (•OH) for antibacterial in the early stage of wound healing and collapses gradually. The outer layer is composed of gelatin and dopamine. In the later stage of wound healing, the outer layer contacts the skin, which is beneficial for ROS clearance on the wound. Antibacterial, ROS scavenging, and wound healing experiments have shown that the double-layer hydrogel possesses two-stage ROS regulating properties for programmed diabetic wound healing. In conclusion, it will be one of the most potential dressings for treating diabetic wounds in the future.

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“…It combines biological 3D printing and traditional disordered electrospinning technology to prepare highly ordered microfibers. Zhong and his colleagues prepared PCL fibers/GelMA composite materials with NFES, which has a good effect on promoting the healing of diabetes wounds, showing the broad application prospect of NFES in medical dressings [ 12 ]. Theoretically, the ideal wound dressing should have the advantages of hydrophilicity, antibacterial activity, water absorption property, controllable mechanical properties, biocompatibility, and air permeability [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

PCL/Collagen/UA Composite Biomedical Dressing with Ordered Microfiberous Structure Fabricated by a 3D Near-Field Electrospinning Process

et al. 2022

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In this work, a functionalized polycaprolactone (PCL) composite fiber combining calf-type I collagen (CO) and natural drug usnic acid (UA) was prepared, in which UA was used as an antibacterial agent. Through 3D near-field electrospinning, the mixed solution was prepared into PCL/CO/UA composite fibers (PCUCF), which has a well-defined perfect arrangement structure. The influence of electrospinning process parameters on fiber diameter was investigated, the optimal electrospinning parameters were determined, and the electric field simulation was conducted to verify the optimal parameters. The addition of 20% collagen made the composite fiber have good hydrophilicity and water absorption property. In the presence of PCUCF, 1% UA content significantly inhibited the growth rate of Gram-positive and negative bacteria in the plate culture. The AC-PCUCF (after crosslinking PCUCF) prepared by crosslinking collagen with genipin showed stronger mechanical properties, water absorption property, thermal stability, and drug release performance. Cell proliferation experiments showed that PCUCF and AC-PCUCF had no cytotoxicity and could promote cell proliferation and adhesion. The results show that PCL/CO/UA composite fiber has potential application prospects in biomedical dressing.

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Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

Cited by 36 publications

References 47 publications

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

PCL/Collagen/UA Composite Biomedical Dressing with Ordered Microfiberous Structure Fabricated by a 3D Near-Field Electrospinning Process

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