Breaking of internal lee waves generated by flow‐topography interaction is an important driving mechanism for abyssal mixing. By assuming that lee‐wave‐driven mixing is a local process, direct measurements in the past mainly focused on the water column over rough topography. In this study, a non‐local role of lee waves on remote mixing is investigated by using mooring observations in the northwestern Philippine Basin and a series of 2‐dimensional high‐resolution numerical simulations. We find that the breaking of lee waves can generate near‐inertial waves (NIWs) which can propagate away from their generation sites. The NIWs have strong vertical shear which can significantly elevate turbulent dissipation and mixing over remote uneven seafloor. Based on the topography perturbations numerical experiments, we find that for the remote gentle topography with inverse Froude number (Fr−1) between 0 and 0.5, the arrival of upstream NIWs can elevate the near‐bottom layer (0–1,000 m above bottom) dissipation rate and vertical diffusivity by 9.2 and 10.4 times, respectively at 30–50 km away from the NIWs source. For the remote rough topography with Fr−1 between 0 and 4, the corresponding increases are 3.5 and 4.4 times, respectively. The mechanism of upstream NIWs to elevate the downstream dissipation and mixing is through strengthening the shear instability over the far‐field topography, which is associated with NIWs' interactions with the topography and the generated lee waves therein. The results of this study will provide a foundation for improving the mixing parameterizations associated with current‐topography interactions.