Near-infrared band Gold nanoparticles-Au film “hot spot” model based label-free ultratrace lead (II) ions detection via fiber SPR DNAzyme biosensor

Wang, Fang; Zhang, Yang; Lu, Mengdi; Du, Yunting; Chen, Ming; Meng, Shuxian; Ji, Wei; Sun, Changsen; Peng, Wei

doi:10.1016/j.snb.2021.129816

Cited by 51 publications

(30 citation statements)

References 44 publications

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“…According to the results of the wavelength shifts, the proposed capped gold nanoslit arrays-based sensors performed the Hg 2+ ion selectivity of 10 μM concentration in the mixed ion solutions and were favorable for the label-free detection of Hg 2+ in aqueous solution. The EC-SPR based on the wavelength shifts can also be used to detect other heavy metal ions [ 28 , 29 , 30 ]. The potential performance is different of these ions, which could help experiments to know the qualitative ions and propose an analyzed method by using SPR in aqueous solutions.…”

Section: Resultsmentioning

confidence: 99%

Combination of Capped Gold Nanoslit Array and Electrochemistry for Sensitive Aqueous Mercuric Ions Detection

Chen

Wei

2021

Nanomaterials

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Label-free surface plasmon resonance (SPR) detection of mercuric ions in various aqueous solutions, using capped gold nanoslit arrays combined with electrochemical (EC) sensing technique, is demonstrated. The nanoslit arrays are fabricated on flexible cyclo-olefin polymer substrates by a nanoimprinting lithography method. The EC and SPR signals for the investigation of current responses and transmission SPR spectra are simultaneously measured during metal ions electrodeposition. Glycerol–water solution is studied to evaluate the resonant peak wavelength sensitivity (480.3 nm RIU−1) with a FOM of 40.0 RIU−1 and the obtained intensity sensitivity is 1819.9%. The ferrocyanide/ferricyanide redox couple performs the diffusion controlled electrochemical processes (R2 = 0.99). By investigating the SPR intensity changes and wavelength shifts of various mercuric ion concentrations, the optical properties are evaluated under chronoamperometric conditions. The sensors are evaluated in the detection range between 100 μM and 10 nM with a detection limit of 1 μM. The time dependence of SPR signals and the selectivity of 10 μM Hg2+ in the presence of 10 μM interfering metal ion species from Ca2+, Co2+, Ni2+, Na+, Cu2+, Pb2 + and Mn2+ are determined. The capped gold nanoslit arrays show the selectivity of Hg2+ and the EC sensing method is effectively utilized to aqueous Hg2+ detection. This study provides a label-free detection technique of mercuric ions and this developed system is potentially applicable to detecting chemicals and biomolecules.

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Section: Resultsmentioning

confidence: 99%

Combination of Capped Gold Nanoslit Array and Electrochemistry for Sensitive Aqueous Mercuric Ions Detection

Chen

Wei

2021

Nanomaterials

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“…The presence of Pb 2+ activates the catalytic activity of the DNAzyme, and cleavage of the substrate takes place. This is the basis of a pioneer work where the cleavage of the substrate gives rise to a conformational change, and the AuNPs fall closer to the gold film, increasing the measured SPR signal [ 14 ]. In an alternative approach, the AuNPs are removed from the surface of the sensor, decreasing the localized surface plasmon (LSP) and the surface plasmon polariton (SPP) coupling [ 15 ].…”

Section: (Bio)analytical Applications Based On Dnazymes and Npsmentioning

confidence: 99%

Inorganic nanoparticles coupled to nucleic acid enzymes as analytical signal amplification tools

et al. 2022

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Nucleic acid enzymes (NAzymes) are a class of nucleic acid molecules with catalytic activity, which can be modulated by the presence of different species such as metal ions, genetic biomarkers, small molecules or proteins, among others. NAzymes offer several important advantages for development of novel bioanalytical strategies, resulting from their functionality as specific recognition elements and as amplified analytical signal generators, making them ideal candidates for developing highly specific bioanalytical strategies for the detection of a wide variety of targets. When coupled with the exceptional features of inorganic nanoparticles (NPs), the sensitivity of the assays can be significantly improved, allowing the detection of targets using many different detection techniques including visual readout, spectrophotometry, fluorimetry, electrochemiluminescence, voltammetry, and single-particle inductively coupled plasma-mass spectrometry. Here we provide an overview of the fundamentals of novel strategies developed to achieve analytical signal amplification based on the use of NAzymes coupled with inorganic NPs. Some representative examples of such strategies for the highly sensitive detection of different targets will be presented, including metal ions, proteins, DNA- or RNA-based biomarkers, and small molecules or microorganisms. Furthermore, future prospective challenges will be discussed.

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“…In the presence of the cation, the substrate is cut at the cleavage site (deoxyguanosine) and the fragments are released, leaving a part of the substrate strand immobilized on the sensor. In this regard, DNAzymes were exploited for fluorescent and electrochemical sensors for the determination of Pb(II) [9,28,45,63,158,166,167,[172][173][174][175]179,180], Cu(II) [133], Cd(II) [126], Hg(II) [40,135,138], Mg(II) [42], and Ni(II) [157]. In these procedures, substrate strands were labeled with electrochemical and fluorescent probes that showed responses after their disassembly from the platform.…”

Section: Affinitymentioning

confidence: 99%

“…To a lesser extent than electrochemical biosensors, optodes have been applied to element analysis exploiting molecular absorption spectrophotometry (MAS) [104,114], SERS [48,105,178], SPR [64,65,147,179], IRS [108], digital imaging (DI) [109,171], and FL [58][59][60][61][62]150]. The latter was frequently used due to the simplicity of the instrumentation and the ease of detection.…”

Section: Optical and Piezoelectric Sensorsmentioning

confidence: 99%

An overview of Structured Biosensors for Metal Ions Determination

et al. 2021

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The determination of metal ions is important for nutritional and toxicological assessment. Atomic spectrometric techniques are highly efficient for the determination of these species, but the high costs of acquisition and maintenance hinder the application of these techniques. Inexpensive alternatives for metallic element determination are based on dedicated biosensors. These devices mimic biological systems and convert biochemical processes into physical outputs and can be used for the sensitive and selective determination of chemical species such as cations. In this work, an overview of the proposed biosensors for metal ions determination was carried out considering the last 15 years of publications. Statistical data on the applications, response mechanisms, instrumentation designs, applications of nanomaterials, and multielement analysis are herein discussed.

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Near-infrared band Gold nanoparticles-Au film “hot spot” model based label-free ultratrace lead (II) ions detection via fiber SPR DNAzyme biosensor

Cited by 51 publications

References 44 publications

Combination of Capped Gold Nanoslit Array and Electrochemistry for Sensitive Aqueous Mercuric Ions Detection

Combination of Capped Gold Nanoslit Array and Electrochemistry for Sensitive Aqueous Mercuric Ions Detection

Inorganic nanoparticles coupled to nucleic acid enzymes as analytical signal amplification tools

An overview of Structured Biosensors for Metal Ions Determination

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