Near-infrared fluorescent probe for ratiometric Al3+ signaling and imaging through combined PET and ICT mechanisms

Schiff Bases and Multidentate Organic Compounds as Fluorescent Sensors of Al3+: Photophysical, Fluorescent Bioimaging and the Mechanisms

“…The effect of such fields on molecules and solids can be studied with TDDFT to extract features like excitation energies, frequency‐dependent response properties, and photoabsorption spectra [151–153] . In this framework, Ragini Gupta et al [154] . Changyan Sun et al .…”

“…In the case of Cu 2 + and Hg 2 + , significant fluorescence quenching was observed (Scheme 2). [154] Also, important to mention the highlights around the new fluorescent sensor of Al 3 + where the chemical synthesis in two steps is done, the sensor ability can be carried out in aqueous media and the emission in the Near-Infrared region by chelation of Al3 + . The BPD sensor increase the lifetime by the addition of Al 3 + till 8.09 ns while the free ligand was 6.31 ns.…”

A novel AIE fluorescent probe for the monitoring of aluminum ions in living cells and zebrafish

“…[13][14][15][16][17][18][19] By contrast, significant progress has been achieved in the development and application of fluorescent probes for the selective binding and identification of different metals, exhibiting unique properties including operational simplicity, low cost, high sensitivity and high selectivity. 20,21 Until now, some fluorescent probes for detecting Al 3+ have been reported based on internal charge transfer (ICT), [22][23][24] photoinduced electron transfer (PET), [25][26][27][28][29] chelation-enhanced fluorescence (CHEF), [30][31][32] and fluorescence resonance energy transfer (FRET) mechanisms. 33 However, most of these probes need to be applied in the organic/water mixture for the detection of Al 3+ ; the Al 3+ ion easily dissolves in water medium.…”

Acridino-Diaza-20-Crown-6 Ethers: New Macrocyclic Hosts for Optochemical Metal Ion Sensing

“…The recently published Al 3+ -selective optochemical sensors [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ] were similarly compared. Due to the similar atomic radius and valence to Mg 2+ , Ca 2+ and Fe 3+ , Al 3+ can act as a competitive inhibitor of these ions in biological processes [ 34 ] and can also induce neurodegenerative disorders [ 41 ].…”

“…It appears that the majority of Al 3+ -sensors show similar characteristics in operation—i.e., in the applied semi-aqueous medium, similar association constants (log K = 3.5–7.5) and low limits of detection (6.0 × 10 −6 M–2.7 × 10 −8 M), below the tolerance limit in drinking water (~7.4 × 10 −6 M [ 42 , 43 ]) —as those reported for Zn 2+ -selective ones [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Unfortunately, the selectivity of the reported sensor molecules is often limited due to the interference of other cations, which were typically Ni 2+ [ 28 , 31 ], Cu 2+ [ 30 , 31 , 32 , 40 ], Hg 2+ [ 30 , 32 ], Fe 2+ [ 31 ], Mg 2+ [ 36 ], and especially trivalent ions like Cr 3+ [ 30 , 36 , 40 ]. In the case of Al 3+ -sensors, the study of pH-dependence is of high importance as Al 3+ acts as a Lewis acid in water, thus adding it into a sample solution definitely results in a change of pH, which affects the photophysical behavior of the chemosensors.…”