Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy

Lorenz, Anna St; Buabeng, Emmanuel Ramsey; Taratula, Oleh; Henary, Maged

doi:10.1021/acs.jmedchem.1c00771

Cited by 37 publications

(20 citation statements)

References 39 publications

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“…Recently, polymer-encapsulated nanoparticles and nanomicelles of derivatives of heptamethine cyanine and boron dipyrromethene dyes have been demonstrated as candidate PTT and PAI agents. 31 , 32 …”

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confidence: 99%

“…In PTT, for example, cancer cells are targeted by selectively and locally exciting materials that efficiently convert light energy into heat and elevate the temperature in the vicinity of the cancer cells. Recently, polymer-encapsulated nanoparticles and nanomicelles of derivatives of heptamethine cyanine and boron dipyrromethene dyes have been demonstrated as candidate PTT and PAI agents. , …”

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confidence: 99%

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Tuning between Quenching and Energy Transfer in DNA-Templated Heterodimer Aggregates

Chowdhury¹,

Dı́az²,

Huff³

et al. 2022

J. Phys. Chem. Lett.

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Molecular excitons, which propagate spatially via electronic energy transfer, are central to numerous applications including light harvesting, organic optoelectronics, and nanoscale computing; they may also benefit applications such as photothermal therapy and photoacoustic imaging through the local generation of heat via rapid excited-state quenching. Here we show how to tune between energy transfer and quenching for heterodimers of the same pair of cyanine dyes by altering their spatial configuration on a DNA template. We assemble “transverse” and “adjacent” heterodimers of Cy5 and Cy5.5 using DNA Holliday junctions. We find that the transverse heterodimers exhibit optical properties consistent with excitonically interacting dyes and fluorescence quenching, while the adjacent heterodimers exhibit optical properties consistent with nonexcitonically interacting dyes and disproportionately large Cy5.5 emission, suggestive of energy transfer between dyes. We use transient absorption spectroscopy to show that quenching in the transverse heterodimer occurs via rapid nonradiative decay to the ground state (∼31 ps) and that in the adjacent heterodimer rapid energy transfer from Cy5 to Cy5.5 (∼420 fs) is followed by Cy5.5 excited-state relaxation (∼700 ps). Accessing such drastically different photophysics, which may be tuned on demand for different target applications, highlights the utility of DNA as a template for dye aggregation.

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confidence: 99%

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confidence: 99%

Tuning between Quenching and Energy Transfer in DNA-Templated Heterodimer Aggregates

Chowdhury¹,

Dı́az²,

Huff³

et al. 2022

J. Phys. Chem. Lett.

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“…For NP-based photothermal therapy and photoacoustic imaging, St Lorenz et al developed nanoparticle systems containing various near-infrared (NIR) heptamethine cyanine dyes, which were incorporated into polymeric NPs to provide water solubility and protection of their photophysical characteristics. 124 In another study, iron-copper doped polyaniline NPs were synthesized, in which the Cu (II) undergoes a redox reaction with glutathione, highly elevated in tumor tissues. 125 This results in a red shift of the absorption spectrum of the NPs enabling a simultaneous photoacoustic tumor imaging and photothermal therapy.…”

Section: Imaging Techniquesmentioning

confidence: 99%

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

Friedrich¹,

Kappes²,

Cicha³

et al. 2022

IJN

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Label-free detection of nanoparticles is essential for a thorough evaluation of their cellular effects. In particular, nanoparticles intended for medical applications must be carefully analyzed in terms of their interactions with cells, tissues, and organs. Since the labeling causes a strong change in the physicochemical properties and thus also alters the interactions of the particles with the surrounding tissue, the use of fluorescently labeled particles is inadequate to characterize the effects of unlabeled particles. Further, labeling may affect cellular uptake and biocompatibility of nanoparticles. Thus, label-free techniques have been recently developed and implemented to ensure a reliable characterization of nanoparticles. This review provides an overview of frequently used label-free visualization techniques and highlights recent studies on the development and usage of microscopy systems based on reflectance, darkfield, differential interference contrast, optical coherence, photothermal, holographic, photoacoustic, total internal reflection, surface plasmon resonance, Rayleigh light scattering, hyperspectral and reflectance structured illumination imaging. Using these imaging modalities, there is a strong enhancement in the reliability of experiments concerning cellular uptake and biocompatibility of nanoparticles, which is crucial for preclinical evaluations and future medical applications.

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“…Hence, multimodal probes have also been developed to aid such imaging/therapeutic systems. 101 – 108 …”

Section: Introductionmentioning

confidence: 99%

Looking deep inside tissue with photoacoustic molecular probes: a review

2022

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. Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution deep tissue imaging. However, label-free PAI signals from light absorbing chromophores within the tissue are nonspecific. The use of exogeneous contrast agents (probes) not only enhances the imaging contrast (and imaging depth) but also increases the specificity of PAI by binding only to targeted molecules and often providing signals distinct from the background. Aim: We aim to review the current development and future progression of photoacoustic molecular probes/contrast agents. Approach: First, PAI and the need for using contrast agents are briefly introduced. Then, the recent development of contrast agents in terms of materials used to construct them is discussed. Then, various probes are discussed based on targeting mechanisms, in vivo molecular imaging applications, multimodal uses, and use in theranostic applications. Results: Material combinations are being used to develop highly specific contrast agents. In addition to passive accumulation, probes utilizing activation mechanisms show promise for greater controllability. Several probes also enable concurrent multimodal use with fluorescence, ultrasound, Raman, magnetic resonance imaging, and computed tomography. Finally, targeted probes are also shown to aid localized and molecularly specific photo-induced therapy. Conclusions: The development of contrast agents provides a promising prospect for increased contrast, higher imaging depth, and molecularly specific information. Of note are agents that allow for controlled activation, explore other optical windows, and enable multimodal use to overcome some of the shortcomings of label-free PAI.

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Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy

Cited by 37 publications

References 39 publications

Tuning between Quenching and Energy Transfer in DNA-Templated Heterodimer Aggregates

Tuning between Quenching and Energy Transfer in DNA-Templated Heterodimer Aggregates

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

Looking deep inside tissue with photoacoustic molecular probes: a review

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