Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy

Li, Wenling; Zhang, Guilong; Liu, Lu

doi:10.3389/fbioe.2021.768927

Cited by 12 publications

(7 citation statements)

References 123 publications

(190 reference statements)

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“…Marketed CQDs reveal analogous photodegradation and cytotoxicity profiles, representing that photodegradation-influenced cytotoxicity is probably characteristic of CQDs irrespective of their chemical composition. Research findings highlighted the vital function of light in CD cytocompatibility (Li et al, 2021).…”

Section: Properties Of Quantum Dotsmentioning

confidence: 99%

Quantum Dots: An Emerging Approach for Cancer Therapy

Devi¹,

Kumar

Tiwari

et al. 2022

Front. Mater.

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Nanotechnology is indisputably a scientific technique that offers the prospect of new therapies, and hope, for the treatment of malignant illnesses. It is a novel technology that offers new approaches for the diagnosis and management of diverse diseases. Although the discovery of Quantum dots (QD) nano-transporters has already led to a few positive developments, QD nano-transporters are still at their initial stage, though have yet proven valuable to society. The excertion of QD indicates conversion in natural imaging along with photograph have established incredible suitability in bio-imaging, new drug development, targeted gene deliverance, biosensing, photodynamic treatment as well as diagnosis. The present review aimed to confer the significance of QD in diagnosis as well as in management of cancer. This review aims to impart fundamental insight as well as conception of QD its merits, properties, utilization as well as mode of action. This review highlight of different designing schemes of QD like hydrothermal, drop-casting, ultrasonic, solvothermal, spin-coating, atomic layer desorption, layer by layer, polymethylmethacrylate aided-transfer, electrochemical, ion beam sputtering deposition. Moreover, we have elaborated on the diverse researches related to cytotoxic examination to reveal that QDs are harmless. Concisely, the present review summarizes the fabrication schemes, current research and utilization of QD in cancer treatment.

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Section: Properties Of Quantum Dotsmentioning

confidence: 99%

Quantum Dots: An Emerging Approach for Cancer Therapy

Devi¹,

Kumar

Tiwari

et al. 2022

Front. Mater.

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“…Recent studies show that the highest tissue transmission starts at 950 nm [5] and the biological autofluorescence is minimized above 1000 nm [3], while the fluorescence of the FDA-approved indocyanine green (ICG) and a variety of other NIR dyes in the development is generally below those thresholds. Furthermore, NIR dyes possess substantially lower quantum yields (QY) than conventional fluorophores [6,7]. This disadvantage can be circumvented by having higher fluorophore photostability allowing longer image acquisition times sufficient for autofluorescence photobleaching and accumulation of substantial signal over noise.…”

Section: Introductionmentioning

confidence: 99%

Five near-infrared-emissive graphene quantum dots for multiplex bioimaging

Valimukhametova,

Fannon,

Topkiran

et al. 2024

2D Mater.

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Due to high tissue penetration depth and low autofluorescence backgrounds, near-infrared (NIR) fluorescence imaging has recently become an advantageous diagnostic technique used in a variety of fields. However, most of the NIR fluorophores do not have therapeutic delivery capabilities, exhibit low photostabilities, and raise toxicity concerns. To address these issues, we developed and tested five types of biocompatible graphene quantum dots (GQDs) exhibiting spectrally-separated fluorescence in the NIR range of 928 – 1053 nm with NIR excitation. Their optical properties in the NIR are attributed to either rare-earth metal dopants (Ho-NGQDs, Yb-NGQDs, Nd-NGQDs) or defect-states (NGQDs, RGQDs) as verified by Hartree-Fock calculations. Moderate up to 1.34 % quantum yields of these GQDs are well-compensated by their remarkable >4-hour photostability. At the biocompatible concentrations of up to 0.5 – 2 mg/mL GQDs successfully internalize into HEK-293 cells and enable in vitro imaging in the visible and NIR. Tested all together in HEK-293 cells five GQD types enable simultaneous multiplex imaging in the NIR-I and NIR-II shown for the first time in this work for GQD platforms. Substantial photostability, spectrally-separated NIR emission, and high biocompatibility of five GQD types developed here suggest their promising potential in multianalyte testing and multiwavelength bioimaging of combination therapies.

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“…In recent years, nanomaterial (NM)-mediated phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has shown great potential as an emerging method for oncotherapy, owing to its advantages of minimal invasiveness, regional selectivity, negligible toxic and side effects, short treatment time, and repeatable treatments [ 1 ]. At present, numerous NMs have been developed for PTT [ 2 ], but the progress of PDT is restricted due to the excitation of most photosensitizers (PSs) only by ultraviolet and visible light, the low electron–hole pair (e − −h + ) separation efficiency, and the reduced therapeutic effect caused by the massive consumption of tissue oxygen (O 2 ) during the treatment process [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors

Jiang,

Sun,

Liu

et al. 2024

J Nanobiotechnol

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Background Photodynamic therapy (PDT) efficacy of bismuth sulfide (Bi2S3) semiconductor has been severely restricted by its electron–hole pairs (e−−h+) separation inefficiency and oxygen (O2) deficiency in tumors, which greatly hinders reactive oxygen species (ROS) generation and further clinical application of Bi2S3 nanoparticles (NPs) in biomedicine. Results Herein, novel Bi2S3/titanium carbide (Ti3C2) two-dimensional nano-heterostructures (NHs) are designed to realize multimode PDT of synchronous O2 self-supply and ROS generation combined with highly efficient photothermal tumor elimination for hypoxic tumor therapy. Bi2S3/Ti3C2 NHs were synthesized via the in situ synthesis method starting from Ti3C2 nanosheets (NSs), a classical type of MXene nanostructure. Compared to simple Bi2S3 NPs, Bi2S3/Ti3C2 NHs significantly extend the absorption to the near-infrared (NIR) region and enhance the photocatalytic activity owing to the improved photogenerated carrier separation, where the hole on the valence band (VB) of Bi2S3 can react with water to supply O2 for the electron on the Ti3C2 NSs to generate ·O2− and ·OH through electron transfer. Furthermore, they also achieve 1O2 generation through energy transfer due to O2 self-supply. After the modification of triphenylphosphium bromide (TPP) on Bi2S3/Ti3C2 NHs, systematic in vitro and in vivo evaluations were conducted, revealing that the synergistic-therapeutic outcome of this nanoplatform enables complete eradication of the U251 tumors without recurrence by NIR laser irradiation, and it can be used for computed tomography (CT) imaging because of the strong X-ray attenuation ability. Conclusion This work expands the phototherapeutic effect of Bi2S3-based nanoplatforms, providing a new strategy for hypoxic tumor theranostics.

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Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy

Cited by 12 publications

References 123 publications

Quantum Dots: An Emerging Approach for Cancer Therapy

Quantum Dots: An Emerging Approach for Cancer Therapy

Five near-infrared-emissive graphene quantum dots for multiplex bioimaging

Bi2S3/Ti3C2-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors

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