Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins

Wang, Song; Zhang, Zhenhua; Wei, Shaohua; He, Fang; Li, Zhu; Wang, Honghui; Huang, Yan; Nie, Zhou

doi:10.1016/j.actbio.2021.05.027

Cited by 53 publications

(42 citation statements)

References 47 publications

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“…Especially at the irradiation time point, the Rapa releasing was remarkably increased due to the local heating effect resulting from PTT mediated by Ti 3 C 2 . Therefore, Ti 3 C 2 as a novel drug-delivery nanosystem could achieve the function of NIR-enhanced drug releasing because of its unique surface characteristic and photothermal conversion characteristic ( Lin et al, 2017a ; Han et al, 2018 ; Wang et al, 2021 ). The photothermal conversion power of Rapa@Ti 3 C 2 was assessed by observing the temperature rise of Rapa@Ti 3 C 2 solution irradiated by the 808 nm laser.…”

Section: Resultsmentioning

confidence: 99%

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Posterior capsule opacification (PCO) is one of the most frequent late-onset complications after cataract surgery. Several kinds of drug-eluting intraocular lenses (IOL) were designed for sustainable drug release to suppress ocular inflammation, the proliferation of lens epithelial cells (LECs) and the development of PCO after cataract surgery. Despite previous advances in this field, the drug-loaded IOLs were limited in ocular toxicity, insufficient drug-loading capacity, and short release time. To prevent PCO and to address these drawbacks, a novel drug-loaded IOL (Rapa@Ti3C2-IOL), prepared from two-dimensional ultrathin Ti3C2 MXene nanosheets and rapamycin (Rapa), was fabricated with a two-step spin coating method in this study. Rapa@Ti3C2 was prepared via electrostatic self-assembly of Ti3C2 and Rapa, with a loading capacity of Rapa at 92%. Ti3C2 was used as a drug delivery reservoir of Rapa. Rapa@Ti3C2-IOL was designed to have the synergistic photothermal and near infrared (NIR)-controllable drug release property. As a result, Rapa@Ti3C2-IOL exhibited the advantages of simple preparation, high light transmittance, excellent photothermal conversion capacity, and NIR-controllable drug release behavior. The Rapa@Ti3C2 coating effectively eliminated the LECs around Rapa@Ti3C2-IOL under a mild 808-nm NIR laser irradiation (1.0 W/cm−2). Moreover, NIR-controllable Rapa release inhibited the migration of LECs and suppressed the inflammatory response after photothermal therapy in vitro. Then, Rapa@Ti3C2-IOL was implanted into chinchilla rabbit eyes, and the effectiveness and biocompatibility to prevent PCO were evaluated for 4 weeks. The Rapa@Ti3C2-IOL implant exhibited excellent PCO prevention ability with the assistance of NIR irradiation and no obvious pathological damage was observed in surrounding healthy tissues. In summary, the present study offers a promising strategy for preventing PCO via ultrathin Ti3C2 MXene nanosheet-based IOLs with synergistic photothermal and NIR-controllable Rapa release properties.

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Section: Resultsmentioning

confidence: 99%

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“…MXene@Agarose NIR HGF Flexible and controllable release of the protein drugs with high precision. [58] MXenes-FA-SP pH Doxorubicin Drug-loading capacity of 69.9% and 48 h long drug release time. [59] Ti 3 C 2 T x @Met@CP pH, NIR Metformin…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Advances of MXenes; Perspectives on Biomedical Research

2022

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The last decade witnessed the emergence of a new family of 2D transition metal carbides and nitrides named MXenes, which quickly gained momentum due to their exceptional electrical, mechanical, optical, and tunable functionalities. These outstanding properties also rendered them attractive materials for biomedical and biosensing applications, including drug delivery systems, antimicrobial applications, tissue engineering, sensor probes, auxiliary agents for photothermal therapy and hyperthermia applications, etc. The hydrophilic nature of MXenes with rich surface functional groups is advantageous for biomedical applications over hydrophobic nanoparticles that may require complicated surface modifications. As an emerging 2D material with numerous phases and endless possible combinations with other 2D materials, 1D materials, nanoparticles, macromolecules, polymers, etc., MXenes opened a vast terra incognita for diverse biomedical applications. Recently, MXene research picked up the pace and resulted in a flood of literature reports with significant advancements in the biomedical field. In this context, this review will discuss the recent advancements, design principles, and working mechanisms of some interesting MXene-based biomedical applications. It also includes major progress, as well as key challenges of various types of MXenes and functional MXenes in conjugation with drug molecules, metallic nanoparticles, polymeric substrates, and other macromolecules. Finally, the future possibilities and challenges of this magnificent material are discussed in detail.

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“…Secondly, hydrogel can realize controllable drug releasing [ 49 – 51 ]. Hydrogels can respond to various stimuli [ 52 ], for example, light [ 53 ], near infrared light (NIR) [ 54 – 56 ], temperature [ 57 , 58 ], pH [ 59 ], magnetic field [ 60 ], enzymes [ 61 ], ionic strength and electric field. The controlled release of drugs can be realized by virtue of the reversible expansion and contraction properties of hydrogels under specific stimulation conditions to fix the size of gel grids.…”

Section: Introductionmentioning

confidence: 99%

Enhanced postoperative cancer therapy by iron-based hydrogels

Zhang

et al. 2022

Biomater Res

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins

Cited by 53 publications

References 47 publications

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Two-dimensional ultrathin Ti3C2 MXene nanosheets coated intraocular lens for synergistic photothermal and NIR-controllable rapamycin releasing therapy against posterior capsule opacification

Advances of MXenes; Perspectives on Biomedical Research

Enhanced postoperative cancer therapy by iron-based hydrogels

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