Near-Infrared-Light-Responsive Copper Oxide Nanoparticles as Efficient Theranostic Nanoagents for Photothermal Tumor Ablation

Gao, Xuan; Zhang, Peng; Du, Kun; Zhang, Manli; Wen, Ding; Yu, Lu; Feng, Jing; Zhang, Hongjie

doi:10.1021/acsabm.1c00410

Cited by 15 publications

(11 citation statements)

References 49 publications

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“…Furthermore, the presence of satellite peaks denotes electronic shake-up, which empirically confirms the existence of CuO in the biphasic system. ,− In corroboration with the O 1s peak fitting, the Cu 2p signal also experienced a promotion of Cu 2+ intensity as a result of Ni doping. This goes to suggest that the photothermal activity was undertaken predominantly by Cu 2+ from CuO, which is an established photothermal material. − Likewise, Ni doping was further confirmed from Ni 2p signal, which cataloged two peaks Ni 2p 3/2 (855.4 eV) and Ni 2p 1/2 (871.1 eV), indicating Ni 2+ (cyan region), as well as two peaks at the binding energy of 861.5 and 880.9 eV, representing Ni 3+ (orange region) − (Figure S4d (Supporting Information)).…”

Section: Resultsmentioning

confidence: 88%

Emergence of the Janus-MOF (J-MOF) Boat as a Nascent Amalgamation in the Arena of Photothermal Desalination

Selvam

Singh

Karna

et al. 2023

ACS Appl. Mater. Interfaces

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The diminution of potable water is a pressing issue in several countries and is the most prioritized obligation of environmental scientists. Thence, the ardent emergence of photothermal interfacial evaporation (PTIE) is seen as a neoteric horizon in the avenue of water remediation. Consequently, for the first time, the decoration of metal–organic frameworks (MOFs) over a Janus architecture as an avant-garde marriage was explored in the domain of photothermal desalination. In this study, a solar absorber was developed by inducing phase change to Ni-doped HKUST-1 (Cu-MOF) via high-temperature calcination to create biphasic CuO/Cu2O caged in N-doped graphene oxide (NGO) sheets. The doping of Ni in the framework demonstrated to enhance the pyrrolic nitrogen (PN) of NGO sheets, which improved the photothermal feature of the solar absorber in union with promoting Cu2+ species as well as enriching the p-type nature of the biphasic configuration for augmented nonradiative relaxation of electrons. In order to take advantage of the robust potential of the designed solar absorber, it was coated over a Janus membrane prepared via the facile approach, composed of poly(methyl methacrylate) (PMMA) and agarose gel having opposing wettability, referred to as the J-MOF boat. This nascent amalgamation recorded a maximum evaporation rate of 1.5 kg/m2 h with pure water and 1.3 kg/m2 h with simulated seawater under 1 sun irradiation. This phenomenon was ascribed to the highly porous agarose layer to facilitate extraordinary water pumping, while concomitantly rejecting salts via capillary action in a nature-mimicking fashion as seen in mangrove trees. The boat-like feature arises from the PMMA layer to conduct PTIE at the water/air interface by uniformly dispersing the localized heat from the solar absorber owing to its low thermal conductivity and three-dimensional (3D) porous structure. Thus, it is believed that this nascent strategy could push the boundaries of solar-driven desalination.

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Section: Resultsmentioning

confidence: 88%

Emergence of the Janus-MOF (J-MOF) Boat as a Nascent Amalgamation in the Arena of Photothermal Desalination

Selvam

Singh

Karna

et al. 2023

ACS Appl. Mater. Interfaces

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“…Cu(II)/LRu/PDA NPs can be used as MR and PAT imaging contrast agents. In this scenario, the doped Cu(II) possesses an unpaired 3d electron, generating the function as a T 1 -weighted contrast agent for MRI. , Under the magnetic field, the T 1 of the surrounding protons will be shortened, which results in a brighter targeting area. On the basis of nuclear magnetic resonance (NMR) spectrometry, the longitudinal relaxation rate ( r 1 ) of Cu(II)/LRu/PDA NPs is calculated as 3.61 mM –1 s –1 (Figure S7a).…”

Section: Resultsmentioning

confidence: 99%

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Zhang

Wang

Liu

et al. 2022

ACS Appl. Bio Mater.

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Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), refers to the therapeutic strategy using a visible or near-infrared (NIR) laser to generate free radicals or heat for noninvasive and localized tumor treatment. However, limited by the low photoconversion efficiency of therapeutic agents, a single treatment method can hardly lead to complete tumor ablation, even when enhancing the power density of the laser and/or prolonging the irradiation duration. In this work, copper ion and ruthenium complex codoped polydopamine nanoparticles (Cu(II)/LRu/PDA NPs) are designed for PDT/PTT dual-mode therapy. The doped LRu in the NPs can generate reactive oxygen species under visible laser irradiation and enable PDT. Because of the strong absorption in the NIR region, PDA can not only generate heat for PTT under irradiation but also be used for photoacoustic tomography (PAT) imaging. Meanwhile, the doping of Cu(II) in the NPs through the coordination with PDA facilitates T1-weighted magnetic resonance imaging (MRI). Thus, MR/PAT imaging-guided PDT/PTT dual-mode therapy is achieved. The in vivo experiments indicate that the Cu(II)/LRu/PDA NPs can accumulate in HeLa tumors with a retention rate up to 8.34%ID/g. MR/PAT imaging can clearly identify the location and boundary of the tumors, permitting precise guidance for phototherapy. Under the combined effect of PDT and PTT, a complete ablation of HeLa tumors is achieved. The current work provides an alternative nanoplatform for performing PDT/PTT dual-mode therapy, which can be further guided by MR/PAT imaging.

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“…Under 808nm laser irradiation, Cu-BTC@PDA NWs demonstrated high PTT conversion capability and better thermal stability during three consecutive cycles. As a result of their paramagnetic characteristics (Cu 2+ , 3d orbitals: 3d 9 ), NWs act as a T 1 MRI contrast agent [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy

et al. 2023

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Herein, we present a one-pot hydrothermal approach for synthesizing metal–organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.32% after PDA coating and exhibited good photothermal stability. Moreover, NWs with a suitable T1 relaxivity coefficient (r1 = 3.01 mg−1 s−1) can be effectively used as magnetic resonance imaging (MRI) contrast agents. By increasing concentrations, cellular uptake studies showed a greater uptake of Cu-BTC@PDA NWs into cancer cells. Further, in vitro studies showed PDA-coated Cu-BTC NWs possess exceptional therapeutic performance by 808 nm laser irradiation, destroying 58% of cancer cells compared with the absence of laser irradiation. This promising performance is anticipated to advance the research and implementation of copper-based NWs as theranostic agents for cancer treatment.

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Near-Infrared-Light-Responsive Copper Oxide Nanoparticles as Efficient Theranostic Nanoagents for Photothermal Tumor Ablation

Cited by 15 publications

References 49 publications

Emergence of the Janus-MOF (J-MOF) Boat as a Nascent Amalgamation in the Arena of Photothermal Desalination

Emergence of the Janus-MOF (J-MOF) Boat as a Nascent Amalgamation in the Arena of Photothermal Desalination

Copper Ion and Ruthenium Complex Codoped Polydopamine Nanoparticles for Magnetic Resonance/Photoacoustic Tomography Imaging-Guided Photodynamic/Photothermal Dual-Mode Therapy

Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy

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