Near-infrared light-responsive inorganic nanomaterials for photothermal therapy

Bao, Zhihong; Liu, Xuerong; Liu, Yangdi; Liu, Hongzhuo; Zhao, Kun

doi:10.1016/j.ajps.2015.11.123

Cited by 230 publications

(139 citation statements)

References 93 publications

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“…PTT agents routinely become more efficient when modified to be NIR activated. 287 Structural and surface modification of NPs, for example, modification of CuS NPs to form nanoflowers 259 or coupling of Cu 2– x Se to the surface of CNTs (to overcome the low molar extinction coefficients of CNTs), 288 can increase the photothermal conversion efficiency and reduce the incident laser power density. Some conventional photosensitizers such as porphyrins have shown superior PDT capability (>75% 1 O 2 generation).…”

Section: Challenges Perspectives and Critical Remarksmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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Section: Challenges Perspectives and Critical Remarksmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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“…Gold nanorods (Au NRs) have been traditionally exploited in biomedical applications including tumor imaging and PTT due to their synthetically tailorable plasmonic properties and good photothermal effects . Despite their usefulness, Au NRs may suffer from severe drawbacks such as poor photothermal stability, high biotoxicity, and relatively high scattering loss . Alternatively, nonstoichiometric copper sulfides (Cu 2− x S) have recently emerged as promising candidates for PTT owing to their stoichiometry‐dependent NIR localized surface plasmon resonances (LSPR) absorption, low‐cost, negligible cytotoxicity, and good photothermal stability.…”

Section: Photothermal Conversion Characterizations Of the Au Nrs Cormentioning

confidence: 99%

Engineering Gold Nanorod–Copper Sulfide Heterostructures with Enhanced Photothermal Conversion Efficiency and Photostability

Leng

Zhang

et al. 2018

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Plasmonic gold nanorods (Au NRs)-copper sulfide heterostructures have recently attracted much attention owing to the synergistically enhanced photothermal properties. However, the facile synthesis and interface tailoring of Au NRs-copper sulfide heterostructures remain a formidable challenge. In this study, the rational design and synthesis of Au NRs-Cu S heterostructures via a one-pot hydrothermal process is reported. Specifically, core-shell and dumbbell-like Au NRs-Cu S heterostructures are obtained with well-controlled interfaces by employing the Au NRs with different aspect ratios. Both core-shell and dumbbell-like Au NRs-Cu S have proven effective as photothermal therapy agents, which offer both high photothermal stability and significant photothermal conversion efficiency up to 62%. The finite-difference time domain simulation results confirm the coupling effect that leads to the enhanced local field as well as the optical absorption at the heterostructure interface. Importantly, these Au NRs-Cu S heterostructures can be compatibly used as an 808 nm laser-driven photothermal therapy agents for the efficient photothermal therapy of cancer cells in vitro. This study will provide new insight into the design of other noble metal-semiconductor heterostructures for a broad range of applications utilizing surface plasmon resonance enhancement phenomena.

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“…In the face of a huge population of cancer patients, the development of new nano‐diagnostic agents and methods with high efficacy and low levels of side effects is of great significance for improving human life quality . Photothermal ablation treatment based on nano‐biomedicine and the use of near‐infrared (NIR) lasers has shown good prospects for application in the fields of micro‐ and non‐invasive tumor treatment . The photothermal conversion material can kill the tumor by absorbing the NIR light and converting it into heat, inducing hyperthermia of the tumor region .…”

Section: Introductionmentioning

confidence: 99%

Injectable Ovalbumin‐Based Composite Implant for Photothermal Tumor Therapy

Zhang

Zheng

et al. 2019

ChemBioChem

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Polymeric hydrogels with three‐dimensional network structures have found tremendous applications in biomedicine. Herein, we report the synthesis of a multifunctional implant based on ovalbumin (OVA) as a carrier capable of synergistically delivering a photothermal transducing agent (polydopamine, PDA) to tumors. The formation of PDA was achieved by utilizing the basicity of OVA, whereas the formation of the hydrogel implant was achieved through the in vitro/in vivo near‐infrared (NIR) laser‐induced hyperthermia of PDA. The as‐prepared PDA@OVA implant exhibits high photothermal conversion efficiency (38.7 %). Once implanted in vivo, the OVA‐based implant shows great versatility in the treatment of malignant tumors. Furthermore, a chemotherapeutic (doxorubicin, DOX) and a contrast agent (iohexol), dispersed in the OVA solution in advance, can also be firmly entrapped in the hydrogel along with the hydrogel formation. It is anticipated that the multifunctional OVA‐based implant, not showing any obvious toxicity to healthy tissue, could be a promising system for synergistic cancer treatment.

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Near-infrared light-responsive inorganic nanomaterials for photothermal therapy

Cited by 230 publications

References 93 publications

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Engineering Gold Nanorod–Copper Sulfide Heterostructures with Enhanced Photothermal Conversion Efficiency and Photostability

Injectable Ovalbumin‐Based Composite Implant for Photothermal Tumor Therapy

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