Near‐Infrared Responsive PEGylated Gold Nanorod and Doxorubicin Loaded Dissolvable Hyaluronic Acid Microneedles for Human Epidermoid Cancer Therapy (Adv. Therap. 2/2018)

Abstract

Human Epidermoid Cancer In article no. https://doi.org/10.1002/adtp.201800008, ZhiYong Qian and co‐workers develop a near‐infrared (NIR) responsive PEGylated gold nanorod (GNR‐PEG) and doxorubicin (DOX) loaded dissolvable hyaluronic acid (HA) microneedle (GNR‐PEG&DOX@HA MN) for human epidermoid cancer therapy. The GNR‐PEG&DOX@HA MNs have good skin penetration capability and the release behavior of the DOX from GNR‐PEG&DOX@HA MNs can be controlled by near infra‐red light. An in vivo antitumor study, shows that transcutaneously delivered GNR‐PEG&DOX@HA MNs demonstrates remarkable antitumor efficacy, such that all treated mice were cured without recurrence after only one treatment.

Recent Advances in the Multifunctional Microneedles: From Design to Cancer Preventing, Diagnosis, and Treatment

“…The resulting MNs showed a strong photothermal effect and heat transfer effect, which can burn tumor tissue and effectively inhibit epidermal cancer both in vitro and in vivo. [102] In addition, this drug release is uncontrollable. To achieve on-demand drug delivery according to the patient's needs and physiological environments, their research group designed a NIR lightresponsive 5-fluorouracil (5-FU) and ICG-loaded mono-methoxypoly (ethylene glycol)-polycaprolactone (MPEG-PCL) nanoparticle (5-FU-ICG-MPEG-PCL), then 5-FU-ICG-MPEG-PCL was integrated with the hyaluronic acid soluble MNs system (HA MNs) to obtain 5-FU-ICG-MPEG-PCL loaded HA MNs (5-Fu-ICG-MPEG-PCL@HA MNs) for the treatment of skin cancer (Figure 8a).…”

Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles

“…For maturation and activation of APCs, the efficient delivery of antigens and immunomodulators called adjuvants is critical. Microneedles (MNs) have emerged as an attractive way to overcome the skin barrier for cutaneous drug delivery in a minimally invasive manner. , MNs represent an array of needles of several hundred microns in length, which can achieve efficient transdermal delivery of biomacromolecules, such as protein or DNA, across the stratum corneum. − MNs can avoid unnecessary pain as the length of the MN is long enough to pierce skin but does not stimulate dermal nerves and may not require professional training for administration. − MNs are especially useful for the delivery of vaccines as transdermal vaccine delivery has advantages over intramuscular or subcutaneous administrations due to a relative abundance of resident Langerhans cells and APCs, including DCs and macrophages, in the epidermis and dermis of skin. − Among various types of MNs, dissolving MNs have attracted much attention due to their ease of preparation and improved safety. , Unlike solid and hollow MNs that pose the risk of breakage in the skin, dissolving MNs do not leave the debris of needles underneath the skin, minimizing the risk of inflammation caused by foreign materials. , Dissolving MNs also enable efficient cutaneous drug delivery via the rapid dissolution of the matrix upon contact with moisture in the intradermal region, which allows recovery of the damaged skin layer before removal of the patch to prevent potential infection . As dissolving MNs should undergo rapid dissolution in intradermal fluid, their matrices mostly consist of water-soluble sugars and polymers.…”