Near infrared spectroscopy: finding utility in malignant hemispheric stroke

Carandang, Raphael A.; Krieger, Derk

doi:10.1007/s12028-007-0023-y

Cited by 7 publications

(9 citation statements)

References 39 publications

(41 reference statements)

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“…Amongst many potential applications, NIRS/DOS has been utilized for cerebral monitoring of adults with traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) [440–445], ischemic stroke [80, 277–280, 446–453], sleep apnea and other sleep disorders [454–457], intraoperative brain monitoring [458, 459] and in neonates and children [433, 460–462]. This list is not exhaustive; it is meant to give a “flavor” of the field.…”

Section: Optical Monitoring Of Cerebral Hemodynamicsmentioning

confidence: 99%

Diffuse optics for tissue monitoring and tomography

et al. 2010

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This review describes the diffusion model for light transport in tissues and the medical applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue hemodynamics, wherein quantitative assessment of oxy- and deoxy-hemoglobin concentrations and blood flow are desired. The theoretical basis for near-infrared or diffuse optical spectroscopy (NIRS or DOS, respectively) is developed, and the basic elements of diffuse optical tomography (DOT) are outlined. We also discuss diffuse correlation spectroscopy (DCS), a technique whereby temporal correlation functions of diffusing light are transported through tissue and are used to measure blood flow. Essential instrumentation is described, and representative brain and breast functional imaging and monitoring results illustrate the workings of these new tissue diagnostics.

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Section: Optical Monitoring Of Cerebral Hemodynamicsmentioning

confidence: 99%

Diffuse optics for tissue monitoring and tomography

et al. 2010

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“…Previously, spectroscopic optical monitoring (“near-infrared spectroscopy” (NIRS)) has been used for transcranial measurements of total hemoglobin concentration (THC), blood oxygen saturation [17, 18], and, indirectly, for CBF monitoring using an exogenous tracer [19]. In stroke patients, NIRS studies [20] have explored detection of hemispheric CBF and oxygenation reduction [19, 21–23], cerebrovascular reactivity [24, 25], and local functional changes [26–28]. Some studies have shown utility for monitoring acute ischemic stroke longitudinally [29], providing information complementary to the macrovascular CBF obtained with TCD [24].…”

Section: Introductionmentioning

confidence: 99%

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

Durdurán¹,

Zhou²,

Edlow³

et al. 2009

Opt. Express

152

149

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Abstract"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, −5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO 2 ) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.

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“…NIRS noninvasively measures light transmitted through tissues for measurement of blood O 2 saturation or supply, and has been used extensively in clinical and animal studies to monitor cerebral O 2 utilization and saturation in traumatic brain injury in addition to ischemic and hemorrhagic stroke 8143132333435. While the measurement is mostly qualitative, imaging by NIRS is possible in addition to its ability to make repeated real time measurements.…”

Section: Oximetry Methods For Cerebral Po2 Measurementsmentioning

confidence: 99%

In vivo electron paramagnetic resonance oximetry and applications in the brain

Weaver

Liu

2017

Med Gas Res

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Molecular oxygen (O2) is essential to brain function and mechanisms necessary to regulate variations in delivery or utilization of O2 are crucial to support normal brain homeostasis, physiology and energy metabolism. Any imbalance in cerebral tissue partial pressure of O2 (pO2) levels may lead to pathophysiological complications including increased reactive O2 species generation leading to oxidative stress when tissue O2 level is too high or too low. Accordingly, the need for oximetry methods, which assess cerebral pO2 in vivo and in real time, is imperative to understand the role of O2 in various metabolic and disease states, including the effects of treatment and therapy options. In this review, we provide a brief overview of the common in vivo oximetry methodologies for measuring cerebral pO2. We discuss the advantages and limitations of oximetry methodologies to measure cerebral pO2 in vivo followed by a more in-depth review of electron paramagnetic resonance oximetry spectroscopy and imaging using several examples of current electron paramagnetic resonance oximetry applications in the brain.

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Near infrared spectroscopy: finding utility in malignant hemispheric stroke

Cited by 7 publications

References 39 publications

Diffuse optics for tissue monitoring and tomography

Diffuse optics for tissue monitoring and tomography

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients

In vivo electron paramagnetic resonance oximetry and applications in the brain

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