Near-Infrared Spectroscopy in Stroke: From Research to Clinical Practice

Hargroves, David; Tallis, Ray; Pomeroy, Valerie M.; Bhalla, Ajay

doi:10.1161/01.str.0000144656.77330.18

Cited by 14 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another critical point in the discussion about quality and significance of CBF measurements obtained with the NIRS ICG dye method is the influence of extracerebral tissue [3] and the associated blood flow [26]. The present measurements were performed with a commercial NIRS system not having the option of depth-resolved NIRS with time of flight (TOF) distribution.…”

Section: Discussionmentioning

confidence: 99%

Section: Appendix Amentioning

confidence: 99%

“…However, the search for an easy, safe and reliable method to measure cerebral blood flow (CBF) with high resolution rapidly and repeatedly at the bedside in the intensive care unit (ICU) is still a matter of investigation. Despite its limitations, near-infrared spectroscopy (NIRS) is seen as a convenient tool [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Mudra

Muroi

Niederer

et al. 2008

Opto-Electronics Review

View full text Add to dashboard Cite

The cerebral blood flow (CBF) is an important vital parameter in neurointensive care. Currently, there is no non-invasive method for its measurement that can easily be applied at the bedside. A new tool to determine CBF is based on near-infrared spectroscopy (NIRS) applied together with indocyanine green (ICG) dye dilution. From a bilateral measurement on selected regions on the head of infrared (IR) absorption at various wavelengths during the dilution maneuver, the vascular perfusion characteristics of the two brain hemispheres can be determined in terms of mean transit time (mtt) of ICG, cerebral blood volume (CBV) and CBF.So far, on nine healthy volunteers, NIRS ICG dye dilution bihemispheric measurements were performed, which yielded to mtt given as median (range) of 9.3 s (5.1–16.3 s), CBV of 3.5 ml/100 g (1.7–4.1 ml/100 g), and CBF of 18.2 ml/(100 g×min) [11.1–48.6 ml/(100 g×min)]. Additionally, the blood flow index (BFI) was calculated with BFI= 13.8 mg/(100 g×s) [6.6–15.2 mg/(100 g×s)]. The Spearman rank correlation coefficient between CBF and BFI was RS = 0.76. However, as the Bland & Altman plot between CBFNIRS and the CBFBFI documents, the limits of agreement are rather wide (21.9±6.7). Under physiological conditions in healthy volunteers, no differences could be detected between the hemispheres.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Appendix Amentioning

confidence: 99%

See 1 more Smart Citation

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Mudra

Muroi

Niederer

et al. 2008

Opto-Electronics Review

View full text Add to dashboard Cite

show abstract

“…The first is concern over depth of penetrance and contamination of extra cranial tissues [22,24,29,30]. Recent studies [22,28,31,32] using depth resolution, multiple probes and a layered model of the human head as well as using cutaneous laser doppler have extracted extracerebral tissue responses. The depth of penetrance is 2-3 cms.…”

mentioning

confidence: 99%

“…Some papers [34,35] question the accuracy of NIRS during focal hemodynamic changes and sensor probe geometry and probe placement and propose the use of diffuse optical tomography. A third problem is that cerebral hemoglobin oxygen saturation may estimate cerebral blood volume but cannot be equated to cerebral blood flow [32] because of various contributions of other vascular compartments as well extracranial tissues. However, Terborg and colleagues were able to measure cerebral perfusion at the bedside using Indocyanin Green tracer in 13 patients with acute ischemic infarction utilizing bilateral NIRS measurements and reported increased time to peak values with good sensitivity and specificity [36].…”

mentioning

confidence: 99%

Near infrared spectroscopy: finding utility in malignant hemispheric stroke

Carandang

Krieger

2007

Neurocrit Care

View full text Add to dashboard Cite

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Wang

et al. 2022

Journal of Biophotonics

View full text Add to dashboard Cite

Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low‐cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation (n = 5) or air emboli (n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke.

show abstract

Near-Infrared Spectroscopy in Stroke: From Research to Clinical Practice

Cited by 14 publications

References 11 publications

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Near-infrared spectroscopy extended with indocyanine green dye dilution for cerebral blood flow measurement: Median values in healthy volunteers

Near infrared spectroscopy: finding utility in malignant hemispheric stroke

Diffuse optical detection of global cerebral ischemia in an adult porcine model

Contact Info

Product

Resources

About