“…Although these methods have proved effective and sensitive to detect EGFR mutations, they are still labor intensive and may require sophisticated instruments that are not suitable for near-patienttesting (NPT) in clinician's office. NPT is defined to make immediate and informed decisions about patient for earlier diagnosis and disease management in primary care, which leads potentially to improved patient's management and outcome, cost-effectiveness, and reducing health inequalities (Delaney et al, 1999;Khunti, 2010). NPT devices incorporate emerging techniques including silicon biophotonic sensors, electrodes, and solid phase reagents that enable rapid assay reaction, reducing sample and reagent volumes, ease of use, and less technical skill (Crook, 2000;Shin et al, 2015).…”