Nebulized magnesium for prevention of postoperative sore throat

Gupta, Sonali; Tharwani, Santosh; Singh, D.K.; Yadav, Ghanshyam

doi:10.1093/bja/aer437

Cited by 26 publications

(24 citation statements)

References 7 publications

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“…5,6,9 Magnesium, an NMDA receptor antagonist has also been used prophylactically in prevention of postoperative sore throat. 10,11 In our study, there was no statistically significant difference in the distribution of age, gender, ET tube size and duration of surgery.…”

Section: Discussioncontrasting

confidence: 46%

Dose-dependent effectiveness of ketamine nebulisation in preventing post-operative sore throat due to tracheal intubation.

Reddy

Fiaz

2017

Sri Lankan J Anaesthesiol

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Background: Sore throat is a common and distressing post-operative complication following endotracheal intubation that contributes to patient discomfort. Several pharmacological and nonpharmacological methods may be used to attenuate post-operative sore throat. In literature, there is no study evaluating dose-dependent effectiveness of ketamine nebulisation, neither has there been a study to assess patient acceptability with ketamine nebulisation. The prime objective of this study was to assess graded doses of ketamine nebulization in attenuation of post-operative sore throat and patient acceptability and satisfaction. Materials and Methods:90 patients between age group of 18 and 60yrs of ASA physical status 1 and 2 of either sex undergoing surgeries in supine position under general anaesthesia lasting for > 1hr, were randomly allocated into three groups. Group A received 0.5mg/kg, group B received 1mg/kg and group C received 1.5mg/kg body weight of nebulized preservative free ketamine for 15mins, 5mins before intubation. The patients were then assessed for acceptability to ketamine nebulization. At the end of the surgery post-operative sore throat was assessed at 0, 2, 4, 6, 8, 12 and 24hrs.Results: Nebulized ketamine at a dose of 0.5mg/kg was comparatively less effective than 1 mg/kg and 1.5 mg/kg and the difference was statistically significant. 1mg/kg and 1.5mg/kg of nebulized ketamine are better and equally effective in reducing the incidence and severity of post-operative sore throat. There was no statistical difference in the acceptability scores to the different doses of nebulised ketamine. Conclusion:Nebulized ketamine is well accepted by all patients and effective in reducing the severity of post-operative sore throat without any untoward effects. However larger population studies and estimation of serum ketamine levels is needed to find out a better dose of ketamine for nebulization to prevent the incidence and severity of post-operative sore throat.

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Section: Discussioncontrasting

confidence: 46%

Dose-dependent effectiveness of ketamine nebulisation in preventing post-operative sore throat due to tracheal intubation.

Reddy

Fiaz

2017

Sri Lankan J Anaesthesiol

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“…[135456781314] There was no incidence of POST at 12 and 24 h for ketamine and 24 h for magnesium sulfate 500 mg. This could be because of the persistent local action of ketamine and magnesium even at that time.…”

Section: Discussionmentioning

confidence: 99%

Comparison of usefulness of ketamine and magnesium sulfate nebulizations for attenuating postoperative sore throat, hoarseness of voice, and cough

et al. 2017

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Context:Postoperative sore throat (POST) is a complication that is unresolved in patients undergoing endotracheal intubation.Aim:To compare the effects of ketamine and magnesium sulfate nebulizations in two strengths, on the incidence and severity of POST, hoarseness, and cough.Settings and Design:Sixty surgical patients undergoing elective abdominal and lower limb surgeries under combined epidural and general anesthesia were included in this prospective, randomized, double-blinded study.Subjects and Methods:Patients in each group were nebulized with the respective study drug 15 min prior to the surgery, i.e., ketamine in Group K, magnesium sulfate 250 mg, and 500 mg in Group M1 and Group M2, respectively, and normal saline as control in Group C. A standardized anesthesia protocol was followed for all patients. After extubation, the patients were asked to grade POST, hoarseness, and cough at 0, 2, 4, 12, and 24 h.Statistical Analysis Used:One-way analysis of variance, Chi-square test, Fisher's exact test, paired t-tests, and Wilcoxon's signed-rank test as applicable.Results:Ketamine and magnesium sulfate 500 mg demonstrated a statistically significant decrease in POST at 0, 2, and 4 h, and postoperative hoarseness at 0 h. There was decrease in the incidence and severity of sore throat, hoarseness, and cough at all periods in the study groups as compared with control.Conclusion:Nebulization with ketamine 50 mg and magnesium sulfate 500 mg, 15 min before induction of general anesthesia and intubation, reduce the incidence and severity of POST and hoarseness of voice.

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“…Some measures to decrease the POST like nebulising subjects with ketamine and magnesium prior to intubation had been tried with various results. 2,3 Previous studies indicate that ETT intubation is associated with higher incidence of POST than that with LMA. 4,5 The incidence of POST varies from 12% to 63% in various studies, Females were found to have a higher incidence of POST.…”

Section: Introductionmentioning

confidence: 99%

Postoperative sore throat in patients undergone head and neck surgeries under endotracheal intubation and laryngeal mask anaesthesia

Rameshkumar

Ajayakumar

2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Postoperative sore throat (POST) is a frequent complaint among the subjects undergoing head and neck surgeries. Orotracheal intubation with the endotracheal tube (ETT) and laryngeal mask (LM) was used for anaesthesia. This study was aimed to analyze the effect of variation in cuff pressure and size of ETT and LM mask anaesthesia on post-surgical pain. Methods: Patients (ages of 10-79) who underwent head and neck surgeries by ETT intubation and LM anaesthesia were included in the study. The pain was measured as pain score during different cuff pressure and size of tube or mask and data was statistically analyzed. Results: Total 100 subjects of each group and both genders were included in the prospective study. No statistically significant difference could be observed among the number of cases in both groups. Among the patients, females were dominant (p = 0.405). The intensity of pain was gradually decreased during the 2 nd and 3 rd post surgical days in both groups. The frequency of patients with pain in the LMA group was less than that of ETT group on the 1 st day. No correlation between the pain score and cuff pressure or size of ETT and LMA could be evidenced. Conclusions:The postoperative sore throat can be effectively reduced by LMA. The pain score and frequency of patients with pain in the LMA group was less than that of ETT group. No correlation of pain score with different cuff pressure and size of tube or mask could be evidenced.

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Nebulized magnesium for prevention of postoperative sore throat

Cited by 26 publications

References 7 publications

Dose-dependent effectiveness of ketamine nebulisation in preventing post-operative sore throat due to tracheal intubation.

Dose-dependent effectiveness of ketamine nebulisation in preventing post-operative sore throat due to tracheal intubation.

Comparison of usefulness of ketamine and magnesium sulfate nebulizations for attenuating postoperative sore throat, hoarseness of voice, and cough

Postoperative sore throat in patients undergone head and neck surgeries under endotracheal intubation and laryngeal mask anaesthesia

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