No abstract

Background: Hysterectomy is one of the frequently performed major gynecological surgical procedures for various uterine pathologies. TXA has already proven to reduce the uterine blood loss in non-surgical aspect. Various studies had revealed that TXA resulted in a significant reduction of menstrual blood loss in menorrhagic women while not increasing the risk of thrombosis and had been used successfully to treat menorrhagia associated with a number of coagulopathies. Material and Methods: This prospective study conducted on 200 women in Department of Obstetrics &for one year period. They were divided in two groups: Cases: (n=100; women receiving prophylactic Tranexamic Acid) and Control: (n=100; women receiving saline). Estimated the amount of blood loss during surgery. The amount of blood loss during surgery were calculated Estimation of weight of dry towels and mops before autoclaving is noted. Results: Most common age group among Cases and Control was 36-45 years [45% vs. 52%]. Age among. Mean age among cases group (46.69±7.51 years) was significantly higher compared to control study cohort (41.75±7.72). Comparing the duration of operation among both the study groups revealed that time taken for hysterectomy took longer time among Cases (9136.69±26.49) as compared to Control (131.61±26.75) (p=0.004). Post operative hemoglobin level was significantly higher among Case (11.26±12.03) as compared to Control (8.56±1.01). Comparing post operative complications revealed that among both the groups post operative complications were comparable. Use of topical hemostatics was higher among the control (77%) as compared to Cases (37%). Conclusion: Prophylactic treatment with TA in relation to benign elective hysterectomy reduces the overall total blood loss, and the risk of reoperations owing to postoperative hemorrhage as revealed by higher hemoglobin level among cases.

open cholecystectomy to saline or magnesium nebulization groups. The authors concluded that nebulized magnesium before the induction of anaesthesia is an effective method for decreasing the incidence of POST and are to be commended for presenting a novel prophylactic treatment for a familiar problem.I would like to highlight the following issues regarding POST. As the authors discussed, POST is a common cause of patient dissatisfaction. 2 However, it has been demonstrated previously that POST has several risk factors including female sex and younger patient age. 3 Unsurprisingly, anaesthetic management has also been implicated. This goes beyond the airway device and design and includes airway suctioning and the use of succinylcholine. 3 4 Any randomized study evaluating a new therapeutic intervention should consider the multifactorial nature of POST in its design in order to increase the validity of its findings. This should include steps to extensively match not only patient factors but also the specific anaesthetic management in both the control and the treatment group.