Necator americanus: Behaviour in hamsters

Şen, Halil

doi:10.1016/0014-4894(72)90006-9

Cited by 41 publications

(13 citation statements)

References 6 publications

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“…Ltd., Bombay, India and the parasite has been maintained since by regular passage through hamsters as described originally by Sen (1972) and Behnke, Wells & Brown (1986). It is important to note here that N.americanus will only mature to patency following exposure of neonatal (I-3-day-old) hamsters to infection (Rajasekariah, Deb, Dhage & Bose, 1985).…”

Section: Hindustanmentioning

confidence: 99%

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Behnke

Rose

Garside

1993

International Journal for Parasitology

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AbStrBCt-BEHNKEJ.M., ROSE R. and GARSIDE P. 1993. Sensitivity to ivermectin and pyrantel of Ancylosioma ceylanicum and Necator americanus. International Journal for Parasitology 23: 945-952. Experiments were carried out in the hamster to compare the relative susceptibility of Necator americanus and Ancylostoma ceylunicum to treatment with ivermectin. A.ceylanicum was found to be 300 times more sensitive to the anthelmintic with a 50% effective dose (ED,,) of the order of lo-15pg kg-' body weight whilst that for N.americanus approximated to 3-5 mg kg-'. Furthermore, whereas complete clearance of A.ceylunicum was observed with a dose of lOOfig kg-', Namericunus was not totally removed after treatment with 25 mg kg-', the highest dose tested. Both parasites proved equally sensitive to pyrantel with an ED,, of 1-12 mg kg-' for A.ceylanicum and 5-25 mg kg-' for N.americanus. Treatment with pyrantel at 1OOmg kg-' completely eliminated worms of both species and doses of 25-50 mg kg-' were > 90% effective. In addition to worm burdens, changes in host weight and PCV were also recorded and it was shown that both parameters could be used to evaluate the success/failure of treatment.

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Section: Hindustanmentioning

confidence: 99%

Sensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus

Behnke

Rose

Garside

1993

International Journal for Parasitology

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“…Infective larvae of N. americanus were obtained in 1983 from Dr Rajasekariah of CIBA-GEIGY Hindustan Ltd., Bombay, India and the parasite has been maintained since by regular passage through hamsters as described originally by SEN (1972) and (BEHNKE et al (1986a, b). It is important to note here that N. americanus will only mature to patency following exposure of neonatal (1-3 day old) hamsters to infection (RAJASEKARIAH et al, 1985).…”

Section: Parasites and Hostsmentioning

confidence: 99%

“…In particular, density-dependent constraints on the biology of hookworms are poorly documented with the notable exception of effects on the fecundity of female worms (SARLES, 1929;KRUPP, 1961). Some of the limitations of studies employing infected human subjects can be overcome in experimental model systems and in this context the adaptation of two species of hookworms (Necator americanus and Ancylostoma ceylanicum, both infective to man and capable of causing patent infections) for passage through hamsters (SEN, 1972;RAY et al, 1972) has provided an opportunity for comparative studies of aspects of their biology which cannot be readily tackled in man (GARSIDE & BEHNKE, 1989;ROSE & BEHNKE, 1990). Events associated with the establishment, migration and *Author to whom all correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Density-dependent effects on establishment of Necator americanus and Ancylostoma ceylanicum

Norozian-Amiri

Behnke

1993

J. Helminthol.

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“…americanus has no closely related animal species, and the only hosts apart from man in which N . americanus has been successfully maintained in the laboratory are the hamster (Sen 1972) and the rabbit (Bhopale, Menon & Renapurkar 1977, Yoshida & Fukutome 1967. However, the necessity for these animals to be infected within 2-4 days of birth imposes severe limitations on the system, particularly in relation to immunological studies (Rajasekariah et al 1985).…”

Section: Introductionmentioning

confidence: 99%