The European project entitled “Empowering Nurses and Healthcare Professionals to Promote Vaccination and Tackle Vaccine Hesitancy. IENE 11 PROVAC” is an initiative that has been developed by three European Universities (from Spain, Cyprus, and Greece) and an educational organization from Romania. Its goal is to train healthcare professionals to become reliable sources of information as well as address the doubts of the general population. Furthermore, this program aims to create a curriculum, information tools, and a massive online open course (MOOC) targeting healthcare professionals, individuals from disadvantaged groups, and those who are more vaccine hesitant to help them become better informed, overcome their fears, and ultimately strengthen confidence in vaccines. This MOOC aspires to be an example for innovative online courses for healthcare professionals around the world.