The article provides a multicenter retrospective analysis of postoperative complications in patients after ventral hernias repair. The study went on for 10 years and included 628 patients divided into 2 groups. The first group included 510 patients operated on using polypropylene implants (mesh density 60g/m2 ). In the second group (118 patients) a de-epithelized autodermal graft prepared according to the authors' technology was applied. Clavien-Dindo classification was used to describe postoperative complications. The total number of complications in the first group was 22.2%, in the second group — 2.5% (p < 0.01). In the analysis of complications in all patients operated on using both allo- and autograft, the most frequent complications in the form of seroma were noted when implants using the one lay technique — 22.3% (p < 0.05) were installed. The autodermal de-epithelized graft used in ventral hernia plastics, regardless of their localization and size, especially in relapses after alloplasty, may be a good alternative to synthetic grafts.