Neck restaging with sentinel node biopsy in T1‐T2N0 oral and oropharyngeal cancer: Why and how?

Burcia, Vincent; Costes, Valérie; Faillie, Jean Luc; Gardiner, Quentin; Verbizier, Delphine de; Cartier, C.; Jouzdani, E; Crampette, L.; Guerrier, B.; Garrel, R.

doi:10.1016/j.otohns.2009.12.016

Cited by 37 publications

(26 citation statements)

References 20 publications

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“…The year after the publication by Morton et al, Alex et al [4] described a peritumoral intradermal injection of radioactive tracer ( 99m Tc-sulphur-colloid), integrating preoperative imaging and intraoperative gamma probe radiolocalization of SLNs in just one procedure. The SLN concept has since been extensively studied and validated for patients with cutaneous melanoma [27] and breast cancer [28], and studies to date have indicated a high level of accuracy in patients with OSCC [29, 30]. …”

Section: Background and Definitionsmentioning

confidence: 99%

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

Giammarile

Schilling

Gnanasegaran

et al. 2018

Eur J Nucl Med Mol Imaging

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PurposeSentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node entails a sequence of procedures with participation of specialists in nuclear medicine, radiology, surgery, and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node detection in patients with early N0 oral cavity squamous cell carcinoma.MethodsThese practice guidelines were written and have been approved by the European Association of Nuclear Medicine (EANM) and the International Atomic Energy Agency (IAEA) to promote high-quality lymphoscintigraphy. The final result has been discussed by distinguished experts from the EANM Oncology Committee, and national nuclear medicine societies. The document has been endorsed by the Society of Nuclear Medicine and Molecular Imaging (SNMMI).These guidelines, together with another two focused on Surgery and Pathology (and published in specialised journals), are part of the synergistic efforts developed in preparation for the “2018 Sentinel Node Biopsy in Head and Neck Consensus Conference”.ConclusionThe present practice guidelines will help nuclear medicine practitioners play their essential role in providing high-quality lymphatic mapping for the care of early N0 oral cavity squamous cell carcinoma patients.

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Section: Background and Definitionsmentioning

confidence: 99%

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

Giammarile

Schilling

Gnanasegaran

et al. 2018

Eur J Nucl Med Mol Imaging

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show abstract

“…For example, elective neck dissection is currently recommended for all HNC patients with an occult metastatic rate greater than 20% to 30%, (30), which actually might not be necessary for 60% to 70% of patients (31,32) and is associated with high risks and morbidity (33)(34)(35). The standard technetium-99-based SLN biopsy procedure currently suffers from several limitations, including lack of real-time intraoperative visual information (36)(37)(38). PLPs offer a promising method for accurately detecting malignant SLNs with preoperative PET/CT imaging and complementary fluorescence imaging for noninvasive diagnosis, preoperative stratification, and more accurate cancer staging.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage

Muhanna

Cui

Chan

et al. 2016

Clinical Cancer Research

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Purpose: The low survival rate of head and neck cancer (HNC) patients is attributable to late disease diagnosis and high recurrence rate. Current HNC staging has inadequate accuracy and low sensitivity for effective diagnosis and treatment management. The multimodal porphyrin lipoprotein-mimicking nanoparticle (PLP), intrinsically capable of positron emission tomography (PET), fluorescence imaging, and photodynamic therapy (PDT), shows great potential to enhance the accuracy of HNC staging and potentially HNC management.Experimental Design: Using a clinically relevant VX-2 buccal carcinoma rabbit model that is able to consistently develop metastasis to regional lymph nodes after tumor induction, we investigated the abilities of PLP for HNC diagnosis and management.Results: PLPs facilitated accurate detection of primary tumor and metastatic nodes (their PET image signal to surrounding muscle ratios were 10.0 and 7.3, respectively), and provided visualization of the lymphatic drainage from tumor to regional lymph nodes by both preoperative PET and intraoperative fluorescence imaging, allowing the identification of unknown primaries and recurrent tumors. PLP-PDT significantly enhanced cell apoptosis in mouse tumors (73.2% of PLP-PDT group vs 7.1% of PLP alone group) and demonstrated complete eradication of primary tumors and obstruction of tumor metastasis in HNC rabbit model without toxicity in normal tissues or damage to adjacent critical structures.Conclusions: PLPs provide a multimodal imaging and therapy platform that could enhance HNC diagnosis by integrating PET/ computed tomography and fluorescence imaging, and improve HNC therapeutic efficacy and specificity by tailoring treatment via fluorescence-guided surgery and PDT.

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“…The concept employs the detection and later biopsy of the first station of lymph nodes draining a specific anatomical site. SLN has not gained great popularity in the nodal management of head and neck tumors due to the variability in the lymph drainage from the respected anatomical sub-sites and thus is not an established standard of care [88][89][90][91].…”

Section: Neck Node Image Guided Surgerymentioning

confidence: 99%

Image guided surgery in the management of head and neck cancer

Iqbal

Pan

2016

Oral Oncology

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Neck restaging with sentinel node biopsy in T1‐T2N0 oral and oropharyngeal cancer: Why and how?

Abstract: The SN biopsy technique appeared to be the best staging method in cN0 patients and provided evidence that routinely undiagnosed lymph node invasion may have clinical significance.

Cited by 37 publications

References 20 publications

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage

Image guided surgery in the management of head and neck cancer

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