2015
DOI: 10.1016/j.det.2015.03.003
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Necrobiosis Lipoidica

Abstract: Necrobiosis lipoidica is a granulomatous condition presenting as indolent atrophic plaques, often on the lower extremities. There is a multitude of case reports suggesting possible associations and documenting different therapeutic alternatives with varied success. Important complications include ulceration and the development of squamous cell carcinoma. The disease course is often indolent and recurrent despite treatment. This article reviews the etiopathogenesis, clinical presentations, and evidence for trea… Show more

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Cited by 83 publications
(135 citation statements)
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References 101 publications
(103 reference statements)
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“…Caracteriza-se por máculo-pápulas brilhantes, telangiectásicas, amarelo-acastanhadas, com centro atrófico e contornos bem definidos e violáceos [7][8][9][10][11][12]. Apesar de habitualmente assintomáticas, constituindo um problema meramente estético, podem associar-se a prurido, disestesia e podem ocorrer ulcerações dolorosas, sobretudo após traumatismo [2,7,11].…”
Section: Discussionunclassified
“…Caracteriza-se por máculo-pápulas brilhantes, telangiectásicas, amarelo-acastanhadas, com centro atrófico e contornos bem definidos e violáceos [7][8][9][10][11][12]. Apesar de habitualmente assintomáticas, constituindo um problema meramente estético, podem associar-se a prurido, disestesia e podem ocorrer ulcerações dolorosas, sobretudo após traumatismo [2,7,11].…”
Section: Discussionunclassified
“…Treatments can be organized into several categories including topical therapy, local therapy, systemic therapy, surgical treatments, and physical modalities (Fig 4). 1, 2…”
Section: Discussionmentioning
confidence: 99%
“…For our patient, we proposed a reverse treatment algorithm adapted from the approach outlined by Sibbald and Alavi 2 . Because she presented to us on both first- and second-tier systemic medications, we started both topical and local corticosteroid therapy as well as adding additional first- and second-tier systemic treatment with pentoxifylline and prednisone.…”
Section: Discussionmentioning
confidence: 99%
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