Necrobiosis lipoidica

O'Reilly, Kathryn E.; Chu, Julie; Meehan, Shane A; Heller, Patrícia; Ashinoff, Robin; Gruson, Lisa Moed

doi:10.5070/d304c8t43b

Cited by 7 publications

(2 citation statements)

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“…Thyroid disorders, such as Graves disease and Hashimoto disease, have been documented in certain patients with NL lesions on the lower extremities [10,29,100]. Erfurt-Berge et al reported in their 2012 study, that from a group of 52 participants, 7 individuals were found to have thyroid disease [63].…”

Section: Thyroid Diseasementioning

confidence: 99%

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The Intersection of Dermatological Dilemmas and Endocrinological Complexities: Understanding Necrobiosis Lipoidica—A Comprehensive Review

Ionescu,

Petca,

Dumitrașcu

et al. 2024

Biomedicines

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Background: Necrobiosis lipoidica (NL) is a rare granulomatous skin disorder with a predilection for females, often associated with diabetes mellitus (DM). This paper aims to comprehensively review the literature on NL, focusing on its association with DM, thyroid disorders, and the metabolic syndrome. Methods: A systematic search was conducted in English-language literature from inception to October 2023, utilizing PubMed. We identified 530 studies and selected 19 based on clinical significance, statistical support, and relevance to the paper’s goals. Results: The coexistence of NL and DM is prevalent, with rates ranging from 11% to 65.71%. NL may precede DM diagnosis and a correlation between NL and increased daily insulin requirements has been observed in such patients. NL is suggested as a potential prognostic marker for DM complications; however, recent studies question this association, highlighting the need for further research. Studies in the context of NL and Thyroid Disease indicate a correlation, especially with autoimmune thyroiditis. Regarding NL and Metabolic Syndrome, the prevalence of metabolic syndrome among NL patients is notably higher than in the general population. Additionally, DM patients with ulcerated NL commonly exhibit hypertension or obesity, raising questions about the potential influence of hypertension and obesity on NL ulcerations. Conclusion: Additional research is required to untangle the complex connections between NL and various comorbidities.

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Section: Thyroid Diseasementioning

confidence: 99%

“…Following diagnosis, it is critical to keep monitoring for the possible occurrence of ulcerations and treat it aggressively in order to reduce the risk of development into squamous cell carcinoma [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%