Necroptosis, a Potential Therapeutic Target for Neurological Disorders

Chen, Jing; Kostrzewa, Richard M.; Xu, Xingshun

doi:10.1007/978-1-4614-5836-4_166

Cited by 2 publications

(2 citation statements)

References 112 publications

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“…RIPK1 were proved as a core protein in a wide range of aberrant physiological processes like neurodegeneration, autoimmune, inflammatory activation and malignancies [ 13 , 14 ]. Aberrantly expressed RIPK1 has been demonstrated to regulate the cell death pathways, including apoptosis [ 15 ] and necrotic cell death [ 16 ] as well as ferroptosis [ 5 ]. The underlying pathway always leads to activation of MAPKs and NF-κB [ 17 ], along with phosphorylation [ 18 ] and ubiquitination [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Guo

Peng

et al. 2022

Aging

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Receptor interacting protein kinases (RIPKs) are a family of serine/threonine kinases which are supposed to regulate tumor generation and progression. Rare study illustrates the roles and functions of RIPKs family in lung adenocarcinoma (LUAD) comprehensively. Our results indicated that the expression of RIPK2 higher in LUAD patients while RIPK5 (encoded by gene DSTYK) expression was lower. Only RIPK2 had a strong correlation with pathological stage in LUAD patients. Kaplan-Meier plotter revealed that LUAD patients with low RIPK2 or RIPK3 level showed better overall survival (OS), but worse when LUAD patients with high RIPK5. Further, lower expression of RIPK2 and higher expression of RIPK1, RIPK4 and RIPK5 prompted a longer disease free survival (DFS). Genetic alterations based on cBioPortal revealing 16% alteration rates of RIPK2, as well as RIPK5. We also found that the functions of RIPKs family were linked to cellular senescence, protein serine/threonine kinase activity, apoptosis process et al. TIMER database indicated that the RIPKs family members had distinct relationships with the infiltration of six types of immune cells (macrophages, neutrophils, CD8+ T-cells, B-cells, CD4+ T-cells and dendritic cells). Moreover, RIPK2 could be observed as an independent prognostic factor with Cox proportional hazard model analysis. DiseaseMeth databases revealed that the global methylation levels of RIPK2 increased in LUAD patients. Thus, the findings above will enhance the understanding of RIPKs family in LUAD pathology and progression, providing novel insights into RIPKs-core therapy for LUAD patients.

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Section: Discussionmentioning

confidence: 99%

The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Guo

Peng

et al. 2022

Aging

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“…Another avenue in the pathophysiology of schizophrenia spectrum disorders may be provided by necroptosis, a form of regulated, preprogrammed necrotic cell death (cf. Chen et al 2014), that modulates normal/disturbed neurodevelopment, neuroimmunological functioning, and neuroinflammation (Fricker et al 2013;Jouan-Lanhouet et al 2014;Kooijman et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer

Kostrzewa

2015

Neurotox Res

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Schizophrenia spectrum disorders are characterized by symptom profiles consisting of positive and negative symptoms, cognitive impairment, and a plethora of genetic, epigenetic, and phenotypic biomarkers. Assorted animal models of these disorders and clinical neurodevelopmental indicators have implicated neurodegeneration as an element in the underlying pathophysiology. Physical exercise or activity regimes--whether aerobic, resistance, or endurance--ameliorate regional brain and functional deficits not only in affected individuals but also in animal models of the disorder. Cognitive deficits, often linked to regional deficits, were alleviated by exercise, as were quality-of-life, independent of disorder staging and risk level. Apoptotic processes intricate to the etiopathogenesis of schizophrenia were likewise attenuated by physical exercise. There is also evidence of manifest benefits endowed by physical exercise in preserving telomere length and integrity. Not least, exercise improves overall health and quality-of-life. The notion of scaffolding as the outcome of physical exercise implies the "buttressing" of regional network circuits, neurocognitive domains, anti-inflammatory defenses, maintenance of telomeric integrity, and neuro-reparative and regenerative processes.

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Necroptosis, a Potential Therapeutic Target for Neurological Disorders

Cited by 2 publications

References 112 publications

The RIPK family: expression profile and prognostic value in lung adenocarcinoma

The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

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