Necrotizing Duodenitis Caused by &lt;i&gt;Clostridium perfringens&lt;/i&gt; Type A in a Japanese Young Man

Annually, numerous new cases of communicable and non-communicable diseases are diagnosed, and consumption of food/water contaminated with different levels of microbial and chemical agents is responsible for a considerable portion of this burden. Generally, acute foodborne diseases are readily identified, while chronic deleterious effects are often neglected and rarely blamed for health consequences. The present work narrates a journey from consuming foods containing bacteria/bacterial toxins to developing chronic diseases, making humans more susceptible to emerging diseases. We aim to shed light on the chronic effects of foodborne diseases, particularly gastrointestinal disorders (GIDs) and inflammatory bowel diseases (IBDs), which are common chronic symptoms of most foodborne diseases.

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Clostridium perfringens and Escherichia coli Bacteremia in a Patient with Acute Obstructive Suppurative Cholangitis: A Case Report and Review of the Literature

Zhang

Jiang

et al. 2022

Am J Case Rep

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Patient: Male, 74-year-old Final Diagnosis: Acute obstructive suppurative cholangitis Symptoms: Nausea and vomiting and chills Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Rare disease Background: Clostridium perfringens (CP), one of several clostridial species gram-positive bacteria, is a major cause of animal necrosis enteritis and traumatic gangrene. In some reports, CP can cause acute emphysematous cholecystitis in patients with biliary tract infections. However, C. perfringens combined with other aerobic bacteria (eg, E. coli ) in bloodstream co-infection is extremely rare and often fatal. Herein, we present a case of co-infection to underscore this unusual situation so that clinicians can adequately evaluate and treat patients in time. Case Report: A 74-year-old man presented to the Emergency Department half a day after the onset of acute abdominal pain accompanied by nausea, vomiting, and chills. The patient was admitted, following development of jaundice, chills, high fever, confusion, and shock. Computed tomography (CT) revealed that the patient had cholangiectasis with acute obstructive suppurative cholangitis (AOSC). We subsequently performed percutaneous transhepatic gallbladder drainage surgery combined with antibiotics, including ceftriaxone, levofloxacin, and metronidazole. C. perfringens and Escherichia coli infections were identified by in vitro blood culture. Fortunately, the patient responded favorably to treatment in our hospital and was cured within 1 week. Conclusions: We report a rare case of C. perfringens and E. coli bloodstream co-infection in a patient with AOSC. We suggest that anaerobic and aerobic co-infection should be considered in future clinical diagnoses. Effective antibiotic treatment combined with surgical drainage is crucial if mixed infection occurs.

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Necrotizing Duodenitis Caused by <i>Clostridium perfringens</i> Type A in a Japanese Young Man

Cited by 4 publications

References 12 publications

Miscellaneous Diseases of the Small Intestine

Miscellaneous Diseases of the Small Intestine

Foodborne pathogens and their association with well-known enteric infections and emerging non-communicable disorders

Clostridium perfringens and Escherichia coli Bacteremia in a Patient with Acute Obstructive Suppurative Cholangitis: A Case Report and Review of the Literature

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