Necrotizing fasciitis in an HIV-infected patient

Human Immunodeficiency Virus Infection Associated with Necrotizing Fasciitis: A Cohort Study of Texas Population, 2001-2010

“…OF was present in nearly 1 in 2 HIVassociated NF hospitalizations in our cohort. When clinical details were provided in prior case reports 3 of 7 patients with HIV-associated NF had OF [7,8,[10][11][12][13][14]. The rate of OF in the present study is markedly higher than those reported by Endorf and colleagues [31] in the general population, finding any OF in 30.7% of hospitalizations with necrotizing soft tissue infections.…”

“…Our findings may have been affected by underreporting of microbiology, analysis restricted to HIV-associated NF hospitalizations without other reported sites of infection, and administrative data precluding information on specimen sources. Microbiology findings were often not described in case reports [1,5,8,9,12], though tended to be monobacterial isolates when reported [6,10,13].…”

“…However, diabetes was reported only in about 1 in 7 HIV-associated NF hospitalizations, as compared to about 1 in 2 in the general population with NF [2]. Chronic comorbidities were inconsistently described in reported cases HIV-associated NF though, when described, most affected patients had no non-HIV chronic illness [10,[12][13][14] or only a single one [7,11]. The reported chronic comorbidities included hypertension [7] and non-Hodgkin's lymphoma [11], with the later possibly a sequela of AIDS in the affected patient.…”

“…However, occurrence of HIV as an underlying illness among NF patients has not been examined at a population level, with only few case reports of HIV-associated NF described to date [5][6][7][8][9][10][11][12][13][14]. While the risk of HIV-associated NF may exceed that of the general population, there are sparse data on the epidemiology of NF in these patients.…”

Clinical & Microbiological profile of Fournier’s Gangrene in a Tertiary Care Hospital in Bangladesh : A prospective observational study

“…NF is a rapidly spreading, inflammatory infection of the deep fascia, associated with secondary necrotic changes of subcutaneous tissue 7 . It is perhaps the most aggressive form of necrotizing soft tissue infection 8 and can spread rapidly to entire limb within hours 9 .…”