Necrotizing myopathy as a paraneoplastic syndrome associated with renal cell carcinoma

Naert, E.; Bleecker, Jan De; Lumen, Nicolaas; Rottey, Sylvie

doi:10.1179/2295333714y.0000000080

Cited by 8 publications

(6 citation statements)

References 10 publications

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“…Onconeural antibodies occur only in a small proportion of patients with cancer who develop peripheral neuropathy [7]. Previous case reports of paraneoplastic neuropathies associated with RCC have also described negative antibody screens preceding RCC diagnosis [2, 6, 15, 16, 17, 18–20]. Likewise, our patient was seronegative for common paraneoplastic antibodies including anti-Hu, anti-Ma, and anti-CV2 [21].…”

Section: Discussion and Review Of The Literaturesupporting

confidence: 53%

“…The few neurological syndromes associated with peripheral nervous system manifestations of RCC that have been described are limited mainly to case reports. These syndromes are diverse and include motor neuron disease [3, 4, 5], demyelinating polyneuropathies [2], and myopathies [6, 7]. We present a case of clear-cell RCC associated with unique peripheral nervous system characteristics, including features of a demyelinating polyneuropathy and plexopathy as part of a physiologically complex paraneoplastic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

2017

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Neurologic symptoms secondary to a paraneoplastic syndrome may be the presenting manifestation of a previously undiagnosed cancer, and alertness to these syndromes may provide an opportunity for early detection and treatment of a cancer. Paraneoplastic weakness is a rare manifestation of renal cell carcinoma and may present with variable electrophysiological features. We present a case of a patient with progressive weakness, sensory changes, and urinary retention, with electrophysiological features suggestive of a complex peripheral nervous system syndrome. Ultimately, a renal cell mass was detected and resected, resulting in significant clinical improvement. We review the literature, cataloging the known neurologic syndromes and antibodies associated with renal cell carcinoma. This case highlights that paraneoplastic neurological disorders associated with RCC can take on many features and provides a resource to practitioners for early detection of a neurologic paraneoplastic syndrome arising from renal cell carcinoma.

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Section: Discussion and Review Of The Literaturesupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

2017

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“…These authors hypothesized that the occurrence of squamous cell carcinoma in patients with ADPKD is closely related to the development of polymyositis ( 10 ). Although there have been some reports describing other types of myositis related to RCC ( 8 , 9 ), these are the only reports of polymyositis with RCC as a paraneoplastic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Relapse of the myopathy six months after the operation coincided with a diagnosis of liver metastasis. After the initiation of treatment with an mechanistic target of rapamycin (mTOR) inhibitor, the myopathy became less active, so the authors suggested that it had been closely related to the RCC ( 8 ). Nevins et al reported on a 77-year-old woman who developed severe muscle weakness and was diagnosed with dermatomyositis; a solid mass in the left kidney was also noted.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease

et al. 2021

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We herein report a 70-year-old man with malaise and muscle weakness that had developed within a month. The patient also had abdominal fullness due to polycystic kidney disease. Severe proximal skeletal muscle weakness and mild elevation of creatinine kinase to 301 IU/L were noted. A muscle biopsy of the right bicep showed polymyositis. Computed tomography showed a right renal mass, and an analysis after right nephrectomy identified clear cell carcinoma. The muscle weakness subsided one month after nephrectomy and intravenous immunoglobulin therapy. Therefore, we suspect that the development of polymyositis in this patient was closely related to renal cell carcinoma.

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“…Elevated levels of ACTH in the postoperative period may be associated with disease recurrence or progression (7). Naert et al (8) reported a case of necrotizing myopathy in a patient with a right renal mass in whom a remission of myopathy was observed after radical nephrectomy. Hypokalemic metabolic alkalosis may occur in patients with Cushing's syndrome (9).…”

Section: Discussionmentioning

confidence: 99%

Resistant Hypokalemia Improving After Radical Nephrectomy: A Case Report

Dinçkal¹,

Kızılay²,

Kalemci³

et al. 2020

jus

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Paraneoplastik sendromlar, herhangi bir neoplazmaya yanıt olarak gelişen sistemik bozukluklardır ve etkilenen organ sistemine bağlı olarak çeşitli klinik semptomlara neden olabilir. Böbrek hücreli kanser (RCC) ile ilişkili Paraneoplastik sendromlardan biri olan hiperkalsemi, RCC hastalarının yaklaşık %20'sinde görülür. Paraneoplastik hiperkalsemi ve polisitemi gibi klinik durumlar RCC'nin daha sık görülen komplikasyonları olmasına rağmen, hepatik disfonksiyon, galaktore ve Cushing sendromu gibi daha nadir Paraneoplastik sendromlar da vardır. Paraneoplastik Cushing sendromu, RCC'nin Cushing sendromundan sorumlu tüm kanserlerin %2'sini oluşturduğunu ve Cushing sendromuyla ilişkili semptomların cerrahi eksizyondan sonra giderildiğini bildirmiştir (6). Hastamızda serum izole adrenokortikotropik hormon, aldosteron ve kortizol düzeyleri normal olmasına rağmen tedaviye dirençli hipokalemik metabolik alkaloz vardı ve bu Cushing sendromu ile ilişkili değildi. Radikal nefrektomi sonrası klinik tablonun ve laboratuvar değerlerinin tamamen normale dönmesi, hipokalemik metabolik alkolozun RCC ile ilişkili bir Paraneoplastik sendrom olabileceğini düşündürmektedir.

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Necrotizing myopathy as a paraneoplastic syndrome associated with renal cell carcinoma

Cited by 8 publications

References 10 publications

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

Paraneoplastic Peripheral Nervous System Manifestations of Renal Cell Carcinoma: A Case Report and Review of the Literature

Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease

Resistant Hypokalemia Improving After Radical Nephrectomy: A Case Report

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