Necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports

Kreienbuehl, Lukas; Charbonney, Emmanuel; Eggimann, Philippe

doi:10.1186/cc10649

Cited by 3 publications

(5 citation statements)

References 2 publications

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“…However, the small number of patients makes it difficult to assess the strength of association of these factors with a poor prognosis. S. aureus necrotizing pneumonia affects mainly young and previously healthy individuals including children and infants [3,4,7,[24][25][26]. It occurs mainly in the winter season as observed here and by other studies [24,[27][28][29], but to our best knowledge none of these associations have been supported by statistical evidence.…”

Section: Discussionsupporting

confidence: 62%

“…Several authors have noted that primary pneumonia (spread of infection through the respiratory tract) is associated with a poorer prognosis than secondary pneumonia (haematogenous spread of infection from a focus in another organ) [3,4,7,32]. It is suggested that in the latter group, patients whose illness began with a skin and soft tissue infection should be separated from those whose first manifestation was infective endocarditis.…”

Section: Discussionmentioning

confidence: 99%

“…To date about 100 cases of necrotizing pneumonia caused by S. aureus have been reported in the literature mostly in individual case reports or in small series. Meta-analyses comprising several cases from such sources [3][4][5][6] as well as a few larger studies [7,8] have recently been published. The present study provides unique information of this disease in Central Europe through the uniform and detailed processing of the collected data.…”

Section: Introductionmentioning

confidence: 99%

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Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

et al. 2015

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A prospective study (2007-2013) was undertaken to investigate clinical features and prognostic factors of necrotizing pneumonia caused by Staphylococcus aureus producing Panton-Valentine leukocidin (PVL) in the Czech Republic. Twelve cases of necrotizing pneumonia were detected in 12 patients (median age 25 years) without severe underlying disease. Eight cases occurred in December and January and the accumulation of cases in the winter months preceding the influenza season was statistically significant (P < 0·001). The course of pneumonia was very rapid, leading to early sepsis and/or septic shock in all but one patient. Seven patients died and mortality was fourfold higher in those patients presenting with primary pneumonia than with pneumonia complicating other staphylococcal/pyogenic infection elsewhere in the body. The S. aureus isolates displayed considerable genetic variability and were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30 (n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a singleton of ST154 (n = 1), all were reported to be associated with community-acquired infection. Four strains were methicillin resistant. The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

et al. 2015

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“…In contrast, CA-MRSA usually causes SSTIs in otherwise healthy individuals. More severe manifestations can include necrotizing pneumonia (Kreienbuehl et al, 2011), pyomyositis (Burdette et al, 2012), sepsis (Bassetti et al, 2011), osteomyelitis (Kechrid et al, 2011) and necrotizing fasciitis (Changchien et al, 2011). The host factors that predispose certain people to develop severe manifestations compared to the more common SSTIs are not understood.…”

Section: Infections Caused By Mrsamentioning

confidence: 99%

Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus

Watkins

David

Salata

2012

Journal of Medical Microbiology

154

113

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“…В экспериментальных, клинических и эпидемиологических исследованиях показана разница между некротизирующими (PVL) и другими инфекциями, вызванными S. aureus, это объясняется участием в патогенезе различных факторов вирулентности S. aureus. При классической пневмонии, вызванной S. aureus, факторами вирулентности являются токсины, адгезины, ферменты и иммуномодуляторы [61,62]. основным отличием некротизирющих инфекций от заболеваний, связанных с токсинами, является действие PVL на иммунные клетки -мощного активатора и цитотоксина в отношении нейтрофилов, моноцитов и макрофагов человека.…”

Section: концепция патогенеза нпunclassified

Necrotizing pneumonia caused Staphylococcus aureus

Белобородов¹

2014

Epidemiology and Infectious Diseases

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Necrotizing pneumonia caused by S. aureus is infrequent, but very serious illness with a high mortality. Pneumonia arises mainly in children and young adults, develops within several days is accompanied with multiple necroses in lung tissue, often leads to a lethal outcome. The feature ofpathogen is ability to formation ofpore-forming toxin destroying different cells in the body including polymorphonuclear leukocytes. The previous virus infection, for example flu, is considered a contributing factor or the co-infection which creates prerequisites for destruction ofneutrophils in lungs with appearance ofnecroses. S. aureus is not the most frequent causative agent of community-acquired pneumonia therefore empirical therapy does not include antibiotics with the activity against staphylococci which are sensitive or resistant to oxacyllin/meticyllin. As a result empirical regimen of antibacterial therapy appears not to be effective. Early clinical signs are a high fever, blood in the sputum, the presence of cavities in the lungs, a rapid increase in respiratory failure. The microscopy of sputum with detection o a large number of staphylococci allows to establish pathogen at an early stage, before obtaining results oif microbiological tests to prove application ofantibiotics active against staphylococci, and after receiving microbiological data to carry out the final correction ovf antibacterial therapy. Respiratory virus infection preceding peumonia or adverse epidemiological situation (flu epidemic) also is the justification for empiric application of anti-staphylococcal antibiotics in community acquired pneumonia.

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Necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports

Cited by 3 publications

References 2 publications

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus

Necrotizing pneumonia caused Staphylococcus aureus

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