Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter

Riemenschnitter, Cosima; Morand, G; Schouten, Charlotte S.; Rupp, Niels J.; Balermpas, Panagiotis; Gander, Thomas; Däppen, Martina A. Broglie

doi:10.1007/s00405-022-07561-x

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…Treatment of OSCC remains mainly surgical, depending on the anatomic site, with adjuvant radiotherapy added for advancedstage disease. 21 The patient, in this case, underwent hemiglossectomy surgery on the right side of the tongue with the keyhole method followed by chemotherapy; it should be the optimal surgery for the early cancer stage. The selection of appropriate treatment modalities depends on tumor factors such as size (T-stage), location and multiplicity, proximity to the bone, pathological features, histology grade, and depth of invasion.…”

Section: Discussionmentioning

confidence: 94%

The early detection of tongue cancer with the etiology of mechanical trauma

Setyawan,

Anang,

Rahmawati

et al. 2023

Dent. J.

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Background: Oral squamous cell carcinoma (OSCC) occurs in approximately 95% of people older than 40 years; usually, it is diagnosed at the age of 60 years. The etiology of OSCC is multifactorial. Chronic mechanical trauma due to sharp teeth has also been suggested as an etiology of oral squamous of the tongue. Purpose: This case report aimed to describe the etiology of OSCC resulting from mechanical trauma and to prevent further metastasis by correctly diagnosing the lesion earlier. Case: A 49-year-old female patient presented with painful and swollen stomatitis two months ago. No submandibular lymph nodes were palpable. An indurated ulceration and sharp teeth on the right region of the jaw were obtained from the intraoral examination. Malignancy was concluded from Histopathology Examination (HPE) and Magnetic Resonance Imaging (MRI) radiography results. Case Management: Multiple extractions were chosen to eliminate the etiology of mechanical trauma due to sharp teeth, and the patient underwent hemiglossectomy with the keyhole method. Postoperative, the histopathology examination revealed an OSCC of the tongue. The patient is currently in the second cycle of chemotherapy by hematologist-oncologists. Conclusion: The early appropriate diagnosis of a tongue ulcer can prevent metastasis, decrease morbidity, and increase quality of life.

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Section: Discussionmentioning

confidence: 94%

The early detection of tongue cancer with the etiology of mechanical trauma

Setyawan,

Anang,

Rahmawati

et al. 2023

Dent. J.

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“…Larson et al ( 27 ) reported the rate of occult cervical metastases was very low when DOI was ≤4 mm in small (≤2 cm) tongue cancer, despite the existence of unfavorable perineural invasion and lymphovascular invasion. Other researchers ( 28 - 30 ), including the authors of this study, still use 5 mm as the category criterion, and obtain favorable hazard discrimination and prediction capabilities. Such phenomenon may result from the different cohort sources and incorporated factors, and more evidence-based research is required.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram to predict occult cervical metastasis in early oral squamous cell carcinoma

Xu¹,

Chen²,

Yin³

et al. 2023

Ann Transl Med

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Background: Lack of adequate objectivity and universality, available models are still difficult to be applied to clinical practice in predicting occult cervical metastasis of early oral squamous cell carcinoma (OSCC).Taking abnormal metabolic state into consideration, the current model is helpful to distinguish those patients with or without occult cervical metastasis.Methods: This study retrospectively analyzed 330 OSCC patients initially diagnosed cT1-2N0M0 stage and received neck dissection from January 2020 to July 2022. The occult cervical metastasis was identified by pathological examination.. After screening independent risk factors using logistic regression, patients were divided into training and validation cohorts at the ratio of 2:1 randomly, and a novel diagnostic model was constructed. Performances of this model were evaluated by the area under the curve (AUC), calibrating curve, decision curve analysis (DCA) and clinical impact curve (CIC).Results: Of the 330 included patients {age mean [standard deviation (SD)], 61.24 (12.99) years; 202 (61.2%) males}, 49 (14.8%) had occult nodal metastasis. Five variables, including body mass index (BMI) [high odds

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“…In literature, DOI values vary from 1.5 to 10 mm in different studies. Thus, a mean value of 4 mm was taken as significant, and it represents an absolute indication for performing selective neck dissections 25 . The results of our study show a correlation between DOI and the presence of metastases in the lymph nodes of neck dissection specimens.…”

Section: Discussionmentioning

confidence: 99%

“…24 prikazuju rezultate kojima se dokazuje da je DOI najpouzdaniji prognostički parametar OPK-a u stadijumu T1-T2. Granična vrednost DOI u literaturi varira od 1,5 mm do 10 mm u različitim studijama, tako da je za signifikantnu srednju vrenost preuzeta vrednost od 4 mm, koja predstavlja apsolutnu indikaciju za sprovođenje selektivnih disekscija vrata 25 . Rezultati naše studije pokazuju korelaciju između DOI i prisustva metastaza u limfnim nodusima disekata vrata.…”

Section: Diskusijaunclassified

Analysis of lymphocytic infiltrate as a predictive factor of neck metastases in oral squamous cell carcinoma

Trajković,

Krasić,

Stojanović

et al. 2023

Acta stomatologica Naissi

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Introduction: Carcinoma of the stratified squamous epithelium of the oral cavity - oral squamous cell carcinoma (OSCC) is an invasive pathological lesion of the epithelium with varying degrees of squamous differentiation. It is characterized by early and extensive metastases, infiltration of adjacent anatomical structures, frequent recurrences, and a relatively low five-year survival rate of less than 50%. The aim of the study to determine the correlation between the analysis of the lymphocytic infiltrate of biopsy specimens with pathohistologically proven metastases of oral squamous cellular carcinoma on postoperative neck dissection specimens. Material and methods: The study included 42 patients with pathohistologically verified oral squamous cellular carcinoma who underwent surgery at the Department of Maxillofacial Surgery of the Clinic of Dental medicine in Niš in the period from 2018 to 2022. The histopathological analysis included the depth of tumor invasion, histopathological analysis of the lymph nodes of neck dissections, analysis of lymphocytic infiltration, and presence of lymphovascularand perineural invasion. Results: It was determined that the depth of invasion is statistically significantly different regarding the degree of lymphocytic infiltration (p=0.004). Invasion of over 4mm was present in 20% of patients with high infiltration, 44.4% of patients with medium infiltration, and 85.7% of patients with low infiltration. Conclusion: Given that the results of the study indicate that the analysis of the lymphocytic infiltrate can be a reliable predictive factor of the appearance of metastases in the lymph nodes of the neck, further research should be directed toward as sociating lymphocytic infiltration with certain biochemical and genetic parameters based on which a plan can be created for neck treatment in the N0 stage of oral squamous cellular carcinoma.

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Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter

Cited by 4 publications

References 35 publications

The early detection of tongue cancer with the etiology of mechanical trauma

The early detection of tongue cancer with the etiology of mechanical trauma

Development and validation of a nomogram to predict occult cervical metastasis in early oral squamous cell carcinoma

Analysis of lymphocytic infiltrate as a predictive factor of neck metastases in oral squamous cell carcinoma

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