Need for Albumin Adjustments of Urgent Total Serum Calcium

Iqbal, S. J.; Ledger, Séadna; Giles, M.; Nanji, N.; Howl, T.

doi:10.1016/s0140-6736(88)90945-2

Cited by 16 publications

(7 citation statements)

References 8 publications

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“…Serum calcium is found in free as well as in bound form with proteins especially albumin. Adjustment of serum total calcium concentration (corrected calcium) for albumin is essential for the diagnosis of hypo and hypocalcaemia [11]. Phosphorous has paramount effect in conjunction with calcium on development of bones [12].…”

Section: Introductionmentioning

confidence: 99%

Levels of Calcium, Corrected Calcium, Alkaline Phosphatase and Inorganic Phosphorus in Patients’ Serum with β-Thalassemia Major on Subcutaneous Deferoxamine

Saboor¹

2014

J Hematol Thrombo Dis

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Section: Introductionmentioning

confidence: 99%

Levels of Calcium, Corrected Calcium, Alkaline Phosphatase and Inorganic Phosphorus in Patients’ Serum with β-Thalassemia Major on Subcutaneous Deferoxamine

Saboor¹

2014

J Hematol Thrombo Dis

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“…At present therefore, though not ideal, albumin-adjusted calcium is used and should be used for most patients. 8 We are aware of the limitations of 'albuminadjusted' calcium. The correction factor and reference range for this measurement depend on the analytical methods for both calcium and albumin and should be determined for each laboratory as should the range of serum albumin concentrations over which the factor can be applied.…”

Section: Discussionmentioning

confidence: 99%

Venepuncture for calcium assays: should we still avoid the tourniquet?

McMullan

Burns²,

Paterson³

1990

Postgraduate Medical Journal

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Summary:Blood was collected by venepuncture from nine healthy subjects over a ten minute period before applying a standard tourniquet, and over a ten minute period afterwards. Plasma ionised calcium was unaltered by the tourniquet, whereas total calcium, total protein and albumin in serum increased modestly. However, there was no effect on total calcium adjusted for albumin. Even without albumin adjustment the change in total calcium was negligible within one minute of the application of the tourniquet. We consider that in ordinary clinical practice, there is no need to perform venepuncture for calcium assays without a tourniquet.

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“…The maintenance of serum calcium concentrations in the face of signifi cant overall defi cits in calcium balance occurs at the expense of bone integrity. Total serum calcium concentrations are dependent upon circulating concentrations of albumin and to a smaller extent upon circulating concentration of globulins (56,108,175,191,253,269,327). Table 1 (top panel) shows normal serum calcium concentrations in males and females measured at the Mayo Clinic.…”

Section: Calcium Balancementioning

confidence: 99%

“…Since globulins bind calcium less avidly than does albumin, a 1-g/dl change in globulins results in a 0.16-mg/dl change in total serum calcium (56,108,175,191,253,269,327). Since globulins bind calcium less avidly than does albumin, a 1-g/dl change in globulins results in a 0.16-mg/dl change in total serum calcium (56,108,175,191,253,269,327).…”

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confidence: 99%