Needle knife therapy plus sodium hyaluronate injection for knee osteoarthritis

Xie, Kunming; Pan, Xuyue; Huang, Fasen; Ma, Yufeng; Qi, Yinze; Wu, Jim Zhen; Ma, Zhanhua; Li, Xinyu; Liang, Huan; Wang, Shulong; Lei, Zhen; Tao, Jingwei; Zhu, Hanjie; Chen, Zhaojun

doi:10.1097/md.0000000000023242

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…It can play a lubricating role to reduce the friction between the tissues in the joint cavity after the injection into the joint cavity; it can also promote synovial cells to synthesize polymeric hyaluronic acid to increase the concentration and molecular weight of sodium citrate in the joint fluid and change the viscosity of the joint fluid. In addition to protecting joint cartilage and promoting healing and regeneration of joint cartilage, sodium hyaluronate can also significantly improve the inflammatory response of tissues, relieve pain, and improve joint function [ 5 , 6 ]. KOA belongs to the category of “rheumatism” in traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Gong

Wei

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Knee osteoarthritis (KOA) has become one of the leading causes of workforce loss in the middle-aged and elderly population and a global public health problem second only to cardiovascular disease, so we need to find more effective treatments for this disease. In this study, we selected 120 patients with KOA admitted to our hospital from June 2018 to December 2020 and divided them into treatment group 1, treatment group 2, and joint group according to the random number table method, with 40 patients in each group. Treatment group 1 was treated with Tongluozhitong prescription dip-soaking therapy, treatment 2 group was treated with intra-articular injection of sodium hyaluronate, and the joint group was treated with a combination of both modalities for 4 weeks in all three groups. Clinical efficacy, visual analogue scale (VAS), Lysholm knee score (LKS), activity of daily living score (ADL), the levels of bone metabolic markers such as cartilage oligomeric matrix protein (COMP), type II collagen degradation maker (CTX-II), and matrix metalloproteinase-3 (MMP-3), and the levels of inflammatory mediators such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and hypersensitive C-reactive protein (hs-CRP) were used as observations to compare and analyze the therapeutic effects of the three treatment regimens in KOA patients. The results showed that the clinical excellence rates of the joint group, treatment group 1, and treatment group 2 were 72.50%, 50.00%, and 90.00%, respectively, with statistically significant differences between any two comparisons. After treatment, VAS scores, serum COMP, CTX-II, MMP-3, IL-1β, TNF-α, and hs-CRP levels decreased in all three groups, and the levels of each index were as follows: joint group < treatment group 1 < treatment group 2, and the difference between any two comparisons was statistically significant. The LKS score and ADL score increased in all three groups, and the levels of each index were as follows: joint group > treatment group 1 > treatment group 2, with statistically significant differences in any two groups compared. None of the patients in the three groups experienced any significant adverse effects during treatment. This suggests that the dip-soaking therapy of Tongluozhitong prescription is more advantageous than intra-articular sodium hyaluronate injection treatment in suppressing the level of serum bone metabolic markers and inflammatory mediators, reducing pathological joint damage, relieving symptoms of pain, alleviating degenerative joint symptoms, and improving knee function in KOA patients. The combination of the two in KOA patients can significantly improve the efficacy and has a good safety profile.

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Section: Introductionmentioning

confidence: 99%

Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Gong

Wei

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Loxoprofen sodium treatment protects the articular cartilage, facilitates regeneration and healing, and may further improve joint and knee function [18]. The IL-1β affects cell membrane receptors, and nociceptive sensitivity and kinase activity are greatly altered [19]. Pain is the primary symptom of patients with knee arthritis, and TNF-α antibody relieves the pain caused by OA, thereby improving allodynia [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment effectiveness (TE) was calculated using Eq 1. The higher the effectiveness, the greater is the number of patients who were healed or showed improvement [19].…”

Section: Treatment Effectivenessmentioning

confidence: 99%

Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function

Zeng¹,

Hu²,

Yang³

et al. 2022

Trop. J. Pharm Res

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Purpose: To determine the treatment efficacy of the combination of loxoprofen sodium and sodium hyaluronate in osteoarthritis (OA), and its role in knee joint function. Methods: 98 patients with OA admitted to Guang'an People's Hospital, Sichuan, China were allocated into control group (CNG, given loxoprofen sodium n, = 51) and study group (SG, given loxoprofen sodium and sodium hyaluronate, n = 47). Both groups were compared in terms of the levels of inflammatory factor, Lysholm, VAS, WOMAC scores, treatment effects, serum MDA, NO, SOD levels, adverse effects, and blood rheology indices. Results: The study group had higher SOD levels, and higher BALP and BGP than CNG (p < 0.05). SG had lower TRACP-5b and blood rheological indices than CNG (p < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (p > 0.05). Conclusion: The combination of loxoprofen sodium and sodium hyaluronate effectively improves the function and blood rheological indices of knee joints. It reduces the occurrence of adverse reactions and the level of pain in patients with OA, and improves OA prognosis. However further clinical trials are required prior to application in clinical practice.

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“…Clinical research has been performed to evaluate the efficacy of acupotomy in treating KOA [ 9 , 10 ]. However, the design of both of these former trials was inadequate.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical practice, acupotomy has been mainly used for the treatment of bone diseases and diseases causing chronic soft tissue injury. Acupotomy can alter the balance of mechanical forces around joints, restore the normal state of joint stress, and alleviate inflammation [ 9 , 10 ]. Therefore, it has a good effect on KOA, frozen shoulder, tennis elbow, and heel pain [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of acupotomy in knee osteoarthritis patients: study protocol for a randomized controlled trial

Lee

Huang

et al. 2021

Trials

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Background Symptomatic knee osteoarthritis (KOA) is common in China. Pharmacological therapy is not the first recommendation because of its safety issues. Nonpharmacological therapy, such as lifestyle adjustments, weight loss, muscle strengthening, and aerobic exercise programs, is strongly recommended for KOA. However, these approaches may fail due to poor patient compliance. There is a lack of high-quality randomized controlled trials of acupotomy, an effective treatment for KOA. This study was designed to investigate the efficacy of acupotomy in patients with KOA. Methods A total of 136 patients will be enrolled at the First Affiliated Hospital of Guangzhou University of Chinese Medicine and assigned to the acupotomy group or sham acupotomy group according to the block randomization scheme. Patients in the acupotomy group will receive 2 sessions of acupotomy for 2 weeks (once a week). Patients in the sham group will receive 2 sessions of sham stimulation for 2 weeks (once a week). All patients will use indomethacin cream externally. The primary outcome will be the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the secondary outcomes will be the visual analog scale (VAS) score, plantar pressure distribution test result, X-ray examination findings, musculoskeletal ultrasound findings, maximum knee circumference, joint mobility, and quality of life. Measurements will be taken at baseline, 1 week after the end of treatment, and at the 3- and 6-month follow-ups. Discussion To the best of our knowledge, this will be the first single-blind, sham-controlled study of acupotomy. The outcome assessors will also be blinded. The aim of this work is to demonstrate the efficacy of acupotomy in treating KOA. Trial registration Chinese Clinical Trial Registry ChiCTR2000033047. Registered on 18 May 2020.

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Needle knife therapy plus sodium hyaluronate injection for knee osteoarthritis

Cited by 6 publications

References 16 publications

Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function

Effect of acupotomy in knee osteoarthritis patients: study protocol for a randomized controlled trial

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