Neem (Azadirachta indica) and its Potential for Safeguarding Health of Animals and Humans: A Review

Tiwari, Ruchi; Verma, Amit Kumar; Chakrabort, Sandip; Dhama, Kuldeep; Singh, Shoor Vir

doi:10.3923/jbs.2014.110.123

Cited by 57 publications

(29 citation statements)

References 50 publications

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“…Is also named “Nimba”, “holy tree”, “Vembu”, “Arishtha”, “Indian neem tree”, “Indian lilac”, “wonder tree”, “village dispensary”, “divine tree”, or “panacea of all diseases”. It has a good growth rate and may reach approximately 15–20 m in height, sometimes up to 35–40 m [26].…”

Section: Neem Plant (A Indica)—botanical Characteristics and Benementioning

confidence: 99%

“…The stem bark of neem contains bioactive compounds as tannins: tricyclic diterpenoids, NB-II peptidoglycan, gallic acid, epigallocatehin, gallocatehin, catechin, epicatechin, margolone, etc. [26].…”

Section: Neem Plant (A Indica)—botanical Characteristics and Benementioning

confidence: 99%

“…The beneficial activity of neem in general health, disease prevention, and treatment (adapted from Tiwari [26]).…”

Section: Figurementioning

confidence: 99%

“…Azadirachta indica (Neem) is an evergreen tree that belongs to the Meliaceae family and is found in tropical and subtropical areas, including India, Burma [26], Pakistan, Bangladesh, and Nepal [24]. Active compounds from neem have been applied in Ayurveda, Unani, and homeopathy, and nowadays, modern medicine is still using this “divine tree” [26] for treatment of many diseases, including infections, metabolic diseases, and cancer [27].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

Moga

Bălan

Anastasiu

et al. 2018

IJMS

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In recent years, a wide range of studies have pointed out the importance of nutraceuticals as reservoirs of therapeutic compounds for several diseases, including cancer. This study is centered on the role of some nutraceuticals as anticancer agents and on their efficiency in the oncological gynecological field. Gynecological cancers include cervical, ovarian, and breast neoplasia and these are the major causes of morbidity and mortality in the female population. Cervical neoplasia affects sexually active women aged between 30 and 40 years and is considered the second leading cause of death for women worldwide. Epidemiological studies have shown a strong association of this cancer with human papilloma virus (HPV) infection, independent of any others risk factors. Ovarian cancer represents about 4% of all women’s cancers and breast neoplasia registers 52.8 new cases per 100,000 women annually. Since ancient times, herbal therapies have shown a wide range of beneficial effects and a high potential for safeguarding human health. Azadirachta indica (Neem) is a medicinal plant of Indian origin, a tree with more of 140 isolated compounds and at least 35 biologically active principles that have shown an important influence as tumor suppressors by interfering with the carcinogenesis process. Used for centuries in Asia as a natural remedy for cancer, neem compounds present in bark, leaves, flowers, and seed oil have been shown to possess properties such as chemopreventive capacity, apoptotic activities, immunomodulatory effects, and induction of p53-independent apoptosis. The current study is a systematic literature review based on the anticarcinogenic potential of neem compounds in gynecological cancers.

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Section: Neem Plant (A Indica)—botanical Characteristics and Benementioning

confidence: 99%

Section: Neem Plant (A Indica)—botanical Characteristics and Benementioning

confidence: 99%

“…The beneficial activity of neem in general health, disease prevention, and treatment (adapted from Tiwari [26]).…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

Moga

Bălan

Anastasiu

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…India is the largest producer of medicinal herbs and is very aptly known as the botanical garden of the world. 3 Azadirachta indica commonly called as neem is being traditionally used from a very long time due to its various beneficial effects including anti-cancer and anti-diabetic effects. 4 More recently Nigella sativa commonly called as black cumin, is also being used in cancer treatment and is also a protective agent against gamma radiation-induced adverse effects in cell lines.…”

Section: Introductionmentioning

confidence: 99%

Investigation of cytotoxicity induced by Nigella sativa and Azadirachta indica using MDA-MB-231, HCT 116 and SHSY5Y cell lines

Banerjee¹,

Pandey²,

Mukherjee³

et al. 2017

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Production of biopesticide azadirachtin using plant cell and hairy root cultures

Thakore

Srivastava

2017

Engineering in Life Sciences

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The extensive use of nondegradable chemical pesticides for pest management has developed serious environmental hazards. This has necessitated the urgent need to switch over to an alternative mode of biopesticide development for mass agriculture and field crop protection. Azadirachta indica A. Juss (commonly known as neem) houses a plethora of bioactive secondary metabolites with azadirachtin being the most active constituent explored in the sector of ecofriendly and biodegradable biopesticides characterized by low toxicity toward nontarget organisms. It has been reported that the highest content of azadirachtin and related limonoids is present in the seeds, available once in a year. Moreover, the inconsistent content and purity of the metabolites in whole plant makes it imperative to tap the potential of in vitro plant tissue culture applications, which would allow for several controlled manipulations for better yield and productivities. This review gives a summarized literature of the applied research and achievements in plant cell/hairy cultures of A. indica A. Juss mainly in context with the biopesticide azadirachtin and applications thereof.

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Neem (Azadirachta indica) and its Potential for Safeguarding Health of Animals and Humans: A Review

Cited by 57 publications

References 50 publications

An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

Investigation of cytotoxicity induced by Nigella sativa and Azadirachta indica using MDA-MB-231, HCT 116 and SHSY5Y cell lines

Production of biopesticide azadirachtin using plant cell and hairy root cultures

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