Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: Histological, biochemical and immunological perspectives

Mallick, Atanu; Ghosh, Sarbari; Banerjee, Saptak; Majumder, Sayantani; Das, Arnab; Mondal, Bipasha; Barik, Subhasis; Goswami, Kuntal Kanti; Pal, Samares; Laskar, Subrata; Sarkar, Koustav; Bose, Anamika; Baral, Rathindranath

doi:10.1016/j.intimp.2012.11.006

Cited by 30 publications

(19 citation statements)

References 23 publications

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“…Neem leaf glycoprotein (NLGP) mitigates deficiencies of the immune system in tumor-bearing hosts through a complex network of actions. Consistent with the effects of NLE, the administration of NLGP in mice and rats increases the count of CD4 + helper T cells, CD8 + cytotoxic T cells, and monocytes [59]. In addition, DX5 + NK cells, CD11b + macrophages, and CD11c + dendritic cells (DCs) are also increased in these animals [59].…”

Section: Neem Components Modulate Tumor Immune Environmentmentioning

confidence: 80%

“…Consistent with the effects of NLE, the administration of NLGP in mice and rats increases the count of CD4 + helper T cells, CD8 + cytotoxic T cells, and monocytes [59]. In addition, DX5 + NK cells, CD11b + macrophages, and CD11c + dendritic cells (DCs) are also increased in these animals [59]. Generation of IgG in vivo, IgG2a in particular, is also enhanced by NLGP [59].…”

Section: Neem Components Modulate Tumor Immune Environmentmentioning

confidence: 86%

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Neem components as potential agents for cancer prevention and treatment

Fang

Kumar

Yadav

et al. 2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Azadirachta indica, also known as neem, is commonly found in many semi-tropical and tropical countries including India, Pakistan, and Bangladesh. The components extracted from neem plant have been used in traditional medicine for the cure of multiple diseases including cancer for centuries. The extracts of seeds, leaves, flowers, and fruits of neem have consistently shown chemopreventive and antitumor effects in different types of cancer. Azadirachtin and nimbolide are among the few bioactive components in neem that have been studied extensively, but research on a great number of additional bioactive components is warranted. The key anticancer effects of neem components on malignant cells include inhibition of cell proliferation, induction of cell death, suppression of cancer angiogenesis, restoration of cellular reduction/oxidation (redox) balance, and enhancement of the host immune responses against tumor cells. While the underlying mechanisms of these effects are mostly unclear, the suppression of NF-κB signaling pathway is, at least partially, involved in the anticancer functions of neem components. Importantly, the anti-proliferative and apoptosis-inducing effects of neem components are tumor selective as the effects on normal cells are significantly weaker. In addition, neem extracts sensitize cancer cells to immunotherapy and radiotherapy, and enhance the efficacy of certain cancer chemotherapeutic agents. This review summarizes the current updates on the anticancer effects of neem components and their possible impact on managing cancer incidence and treatment.

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Section: Neem Components Modulate Tumor Immune Environmentmentioning

confidence: 80%

Section: Neem Components Modulate Tumor Immune Environmentmentioning

confidence: 86%

Neem components as potential agents for cancer prevention and treatment

Fang

Kumar

Yadav

et al. 2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…There are several reported active compounds in neem plant, like nimbin, azadirachtin, nimbidiol, quercetin, and nimbidin [32, 33]. In a study by Mallick et al [34] they confirmed nontoxic effect of neem leaves extract on rat liver and kidney, even in higher doses exceeding the effective dose.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role ofAzadirachta indicaTreatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats

Dkhil

Al‐Quraishy

Aref

et al. 2013

Oxidative Medicine and Cellular Longevity

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Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randomly divided into four groups. CDDP was given to rats by intraperitoneal injection, while MNLE was given by oral gavage for 5 days after the CDDP injection. The injury and oxidative stress caused by CDDP on the liver and the effect of MNLE were evaluated by measuring (a) histological changes, (b) tissue biochemical oxidant and antioxidant parameters, and (c) investigating apoptosis markers immunohistochemically and by real time PCR. After treatment with MNLE, the histological damage and apoptosis induction caused by cisplatin were improved. Malondialdehyde and nitric oxide were significantly decreased; the antioxidant system, namely, glutathione content, glutathione-S-transferase, glutathione peroxidase, catalase, and superoxide dismutase activities were significantly elevated. In conclusion, MNLE may have a potential role when combined with cisplatin in chemotherapy to alleviate cisplatin-induced damage and oxidative stress in liver.

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“…Neem leaf extract possesses anti-inflammatory properties (Kumar et al, 2015), while neem oil acts as an antifertility agent (Kaushic, 2004). Most importantly an active ingredient of neem known as NLGP has now evolved as a potent immunomodulatory agent (Mallick et al, 2013), thus making it an ideal agro-medicinal plant (Figure 1). This unique attribute of neem makes it an ideal bio-pesticidal agent, as it does not cause non-specific toxicity to mammals.…”

Section: Introductionmentioning

confidence: 99%

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

et al. 2017

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Over the years, extensive use of commercially available synthetic pesticides against phytophagous insects has led to their bioaccumulation in the environment causing increased resistance and reduction in soil biodiversity. Further, 90% of the applied pesticides enter the various environmental resources as a result of run-off, exposing the farmers as well as consumers of the agricultural produce to severe health issues. Therefore, growing attention has been given toward the development of alternate environmentally friendly pesticides/insecticides that would aid an efficient pest management system and also prevent chronic exposures leading to diseases. One such strategy is, the use of neem plant's (Binomial name: Azadirachta indica) active ingredients which exhibit agro-medicinal properties conferring insecticidal as well as immunomodulatory and anti-cancer properties. The most prominent constituent of neem is azadirachtin, which has been established as a pivotal insecticidal ingredient. It acts as an antifeedant, repellent, and repugnant agent and induces sterility in insects by preventing oviposition and interrupting sperm production in males. This review discusses, key neem pesticidal components, their active functional ingredients along with recent strategies on employing nanocarriers, to provide controlled release of the active ingredients and to improve their stability and sustainability.

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Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: Histological, biochemical and immunological perspectives

Cited by 30 publications

References 23 publications

Neem components as potential agents for cancer prevention and treatment

Neem components as potential agents for cancer prevention and treatment

The Potential Role ofAzadirachta indicaTreatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats

Progress on Azadirachta indica Based Biopesticides in Replacing Synthetic Toxic Pesticides

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