Negative association of diabetes with rupture of abdominal aortic aneurysm

Takagi, Hisato; Umemoto, Takuya

doi:10.1177/1479164116651389

Cited by 44 publications

(37 citation statements)

References 30 publications

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“…As large aortic diameter and high growth rate represent major risk factors of rupture, 7 it is not surprising that a negative association between DM and aneurysm rupture was identified. 20 …”

Section: Diabetes and The Epidemiology Of Aortic Aneurysmmentioning

confidence: 99%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

135

102

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Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only curative treatment available relies on surgical approaches; drug-based therapies are lacking, highlighting an unmet need for clinical practice. Abdominal aortic aneurysm (AAA) is frequently associated with atherosclerosis and cardiovascular risk factors including male sex, age, smoking, hypertension, and dyslipidaemia. Thoracic aortic aneurysm (TAA) is more often linked to genetic disorders of the extracellular matrix and the contractile apparatus but also share similar cardiovascular risk factors. Intriguingly, a large body of evidence points to an inverse association between diabetes and both AAA and TAA. A better understanding of the mechanisms underlying the negative association between diabetes and aortic aneurysm could help the development of innovative diagnostic and therapeutic approaches to tackle the disease. Here, we summarize current knowledge on the relationship between glycaemic parameters, diabetes, and the development of aortic aneurysm. Cellular and molecular pathways that underlie the protective effect of diabetes itself and its treatment are reviewed and discussed, along with their potential implications for clinical translation.

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Section: Diabetes and The Epidemiology Of Aortic Aneurysmmentioning

confidence: 99%

Diabetes and aortic aneurysm: current state of the art

Raffort

Lareyre

Clément

et al. 2018

Cardiovascular Research

135

102

View full text Add to dashboard Cite

show abstract

“…In addition, several reports have shown that diabetic patients develop smaller aneurysm and have lower growth rates of AAA ( 6 , 8 , 13 - 17 ). At last, a negative association was found between diabetes and AAA rupture ( 18 ). These results suggest a protective effect of diabetes on AAA formation and the understanding of the mechanisms involved could bring innovative therapeutic strategies for the patients.…”

Section: Introductionmentioning

confidence: 99%

Association of abdominal aortic aneurysm diameter with insulin resistance index

Lareyre¹,

Moratal

Zereg³

et al. 2018

Biochemia Medica

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IntroductionEpidemiological studies have highlighted a negative association between diabetes and abdominal aortic aneurysm (AAA). The aim of this study was to investigate the association between insulin resistance and AAA size.Materials and methodsThis prospective cross sectional monocentric study analysed fasting blood samples from 55 patients with AAA eligible for surgical repair. They were divided into 2 groups according to the median AAA diameter: diameter < 50 mm (N = 28) and diameter > 50 mm (N = 27). The median ages were respectively 73 years (62 - 79) and 72 years (67 - 81). Glucose and fructosamine concentrations were determined by spectrophotometry; insulin and C-peptide using chemiluminescent technology. Homeostasis model assessment 2 calculator was used to estimate insulin resistance index (HOMA2 IR).ResultsThere was no significant difference for fasting glucose concentration between the groups (6.1 vs. 5.9 mmol/L, P = 0.825). C-peptide and insulin concentrations, as well as HOMA2 IR index were significantly higher in patients with AAA > 50 mm (0.82 vs. 0.54 nmol/L, P = 0.012; 9 vs. 5 mU/L, P = 0.019 and 1.72 vs. 1.26, P = 0.028, respectively). No linear correlation was identified between AAA diameter and HOMA2 IR. Fructosamine concentration was lower in patients with AAA > 50 mm (225.5 vs. 251 μmol/L, P = 0.005) and negatively correlated with AAA diameter (r = - 0.54, P < 0.001).ConclusionThis study evidenced an association between AAA diameter and insulin resistance. Further studies are required to determine a causal link between insulin resistance and AAA development.

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“…Studies in a variety of populations have reported a strong negative association between diabetes and AAA prevalence, growth and rupture. The cause of this negative association is unknown, but one suggested reason is that medications prescribed to patients to control hyperglycaemia may have pleiotropic effects that could influence AAA growth.…”

Section: Introductionmentioning

confidence: 99%