Negative d-dimer result to exclude recurrent deep venous thrombosis: A management trial

Rathburn, S.W.; Whitsett, Thomas L.; Raskob, Gary E.

doi:10.1016/j.accreview.2005.02.032

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…If these patients were considered to have had a recurrence of DVT, eight of the 134 (6%) would have had a recurrence. Furthermore, as a positive D-dimer test is not suitable for establishing the diagnosis of DVT, a diagnostic dilemma exists in case of a positive D-dimer result and an inconclusive US (Rathbun et al, 2004).…”

Section: Diagnosis Of a Recurrent Episode Lower Extremity Of Deep Veimentioning

confidence: 99%

Diagnostic management of clinically suspected acute deep vein thrombosis

et al. 2009

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SummaryDeep vein thrombosis (DVT) is a common disease that may lead to potentially fatal complications, such as pulmonary embolism. In the past decades several diagnostic tools and algorithms for DVT have been studied. Currently the combination of a clinical decision rule, D-dimer testing and compression ultrasonography has proved to be safe and effective for the diagnosis of DVT in the lower extremities. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) can be useful as additional or secondary imaging modalities. This review will discuss the elements currently used in making the clinical diagnosis of DVT. These elements include clinical decision rules and D-dimer testing, different imaging investigations and the appropriate use of these within diagnostic algorithms in patients with clinically suspected DVT. Although current knowledge of the options available to diagnose DVT of the lower extremities is well established, there are still unresolved issues, including the optimal diagnosis of recurrent DVT and distal DVT. Furthermore, the diagnosis of DVT of the upper extremities will be discussed, including the different imaging modalities and the limitations of these techniques.

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Section: Diagnosis Of a Recurrent Episode Lower Extremity Of Deep Veimentioning

confidence: 99%

Diagnostic management of clinically suspected acute deep vein thrombosis

et al. 2009

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“…Predictive criteria, such as Wells or Modified Wells, (32)(33)(34) can help to reduce unnecessary ultrasounds and improve the control of the situation when the findings are undiagnostic.…”

Section: Initial Examinationmentioning

confidence: 99%

Role of imaging in deep vein thrombosis: a review article

et al. 2020

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Background and Aim: Venous Thrombo Embolism (VTE) refers to the formation of clots in blood vessels. The current study aimed to investigate deep vein thrombosis (DVT) by imaging modalities. Materials and Methods: In this review study, national databases, including Magiran, SID, IranMedex, as well as international ones, namely databases including PubMed, Google scholar, Scopus, and ISI, were searched for related books and articles. The keywords included thrombosis, deep vein thrombosis, imaging, and thrombosis detection. Results: In patients with suspected primary or recurrent deep vein thrombosis, CT venography (CTV) and Magnetic Resonance Venography (MRV) are rarely used on suspicion of iliac vein thrombosis or inferior vena cava (IVC) thrombosis in ultrasound. These examinations have relatively poor reliability, cause adverse side effects of radiation and contrast materials, and are undoubtedly more costly. Conclusion:As evidenced by the obtained results, different methods are available for the diagnosis of deep vein thrombosis. Moreover, it was revealed that ultrasound imaging is the most reasonable method for initial examination due to its sensitivity, specificity, costs, and adverse effects.

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“…Patients with a prior VTE are less likely to be classified as low risk by clinical decision rules, and are therefore more likely to require further diagnostic tests in order to rule out recurrent VTE [2][3][4]. The specificity and clinical utility of D-dimer testing is also lower in patients with a suspected recurrent VTE [5,6]. Furthermore, residual venous obstruction (RVO) is a common finding in patients with prior DVT.…”

Section: Introductionmentioning

confidence: 99%

Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence

Hamadah

Alwasaidi

Gal

et al. 2011

Journal of Thrombosis and Haemostasis

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Summary. Background: After a first unprovoked venous thromboembolism (VTE), many patients have residual pulmonary and/or lower limb vascular obstruction following completion of short‐term anticoagulation. Residual vascular obstruction may complicate the diagnosis of recurrent VTE. Whether baseline imaging, conducted after completion of anticoagulation, helps in interpreting diagnostic testing in patients who subsequently have suspected recurrent VTE is unknown. Study design: The REVERSE study is a cohort study whose primary aim was to derive a clinical decision rule to guide the duration of anticoagulation after a first unprovoked VTE. All patients underwent baseline imaging after completing 5–7 months of anticoagulant therapy. We performed a post hoc randomized controlled comparison among 121 patients investigated for a suspected recurrent VTE during follow‐up: the decision on recurrent VTE with or without baseline imaging was made available to two independent adjudicators. Results: The proportion of patients not classifiable for recurrent VTE was statistically significantly higher in the group with no baseline imaging than in the group with baseline imaging: one in five as compared with one in 25. The interobserver agreement between the two adjudicators was better in the group with baseline imaging than in the group with no baseline imaging: κ‐values were 0.78 and 0.54, respectively. Conclusions: In patients with a first unprovoked VTE, baseline imaging at completion of anticoagulant therapy helps in interpreting diagnostic tests performed in cases of suspected recurrent VTE.

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Negative d-dimer result to exclude recurrent deep venous thrombosis: A management trial

Cited by 3 publications

References 21 publications

Diagnostic management of clinically suspected acute deep vein thrombosis

Diagnostic management of clinically suspected acute deep vein thrombosis

Role of imaging in deep vein thrombosis: a review article

Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence

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