“…Various molecules, including A20, DUBA, RNF125, Pin1, RBCK1, NLRX1, SIKE, DAK, and LGP2, have been shown to regulate induction of type I IFNs by targeting distinct components of the virus-triggered signaling pathways (26)(27)(28). In this report, we found that ISG56 was associated with the adapter protein MITA and disrupted the interaction of MITA with VISA or TBK1, leading to the inhibition of virus-induced IRF3 activation, IFN- expression, and cellular antiviral responses.…”