Negative Lymph Node Count and Lymph Node Ratio Are Associated With Survival in Male Breast Cancer

Abd‐Elhay, Fatma Abd‐Elshahed; Elhusseiny, Khaled Mosaad; Kamel, Mohamed Gomaa; Low, Soon Khai; Sang, To Kim; Mehyar, Ghaleb Muhammad; Minh, Le Huu Nhat; Hashan, Mohammad Rashidul; Huy, Nguyen Tien

doi:10.1016/j.clbc.2018.07.003

Cited by 14 publications

(9 citation statements)

References 57 publications

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“…Additionally, we found that unmarried men are at a higher risk of death from PCa. Our conclusion about marital status was consistent with previous studies [19, 29, 43-46] due to features of marriage, particularly social support, which can have a good impact on the cancer detection, treatment, and even survival.…”

Section: Discussionsupporting

confidence: 92%

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Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

et al. 2020

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Background: Prostate cancer (PCa) is the third leading cause of death from cancer in the United States. We aimed to disclose the prognostic values of examined (dissected) lymph node (ELN), negative lymph node (NLN), and positive (metastatic) lymph node (PLN) counts and lymph node (LNs) ratio in PCa patients. Methods: We extracted data of PCa patients diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) program. We included patients with a histologically confirmed diagnosis having at least one ELN and with the PCa as the primary tumor only. Results: We have included 96,064 patients. Multivariable Cox proportional hazards regression models disclosed that patients having more ELNs were associated with better survival. However, we demonstrated that patients having more PLNs were associated with worse survival. Additionally, older age, unmarried patients, with Gleason's score of 8-10, T4 and M1 stages and those who received chemotherapy and/ or radiation but did not receive surgery were significantly associated with worse PCa survival. Conclusions: We have disclosed several independent predictors affecting PCa patients including age, marital status, Gleason's score, T and N stages, having received therapy, surgery, and ELN and PLN counts. Moreover, we demonstrated that patients with lower ELN and higher PLN counts were a high-risk group. We strongly recommend adding the ELN and/or PLN counts into consideration during patient staging/treatment.

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Section: Discussionsupporting

confidence: 92%

“…Voordeckers et al [17] found that OS was significantly associated with PLN count. Meanwhile, the LNR has been validated as a prognostic factor in several cancers [18, 19]. Interestingly, a lower LNR is associated with both disease-free survival and OS in colon cancer [18].…”

Section: Introductionmentioning

confidence: 99%

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

et al. 2020

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“…Although men with less severe disease exhibit prolonged survival, the prognosis of advanced or metastatic PSCC remains poor, thus requiring a more robust prognostic index than the traditional AJCC TNM staging system. LNR and PLNC have exhibited prognostic value in a variety of tumors, including salivary gland cancer [20], prostate cancer [21], non-small cell lung cancer [22,23], breast cancer [24], and colon cancer [25]. To date, the association between LNR/PLNC and survival in patients with PSCC has not been well elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…LNR and PLNC have exhibited prognostic value in a variety of tumors, including salivary gland cancer [ 20 ], prostate cancer [ 21 ], non-small cell lung cancer [ 22 , 23 ], breast cancer [ 24 ], and colon cancer [ 25 ]. To date, the association between LNR/PLNC and survival in patients with PSCC has not been well elucidated.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of lymph node ratio in comparison to positive lymph node count in penile squamous cell carcinoma

Qian

Zhang

et al. 2021

Int Urol Nephrol

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Purpose Penile cancer is a rare male neoplasm with a wide variation in its global incidence. In this study, the prognostic value of lymph node ratio (LNR) was compared to that of positive lymph node count (PLNC) in penile squamous cell carcinoma. Methods A total of 249 patients with penile squamous cell carcinoma were enrolled from The Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The X-tile program was used to calculate the optimal cut-off values of LNR and PLNC that discriminate survival. We used the χ2 or the Fisher exact probability test to assess the association between clinical-pathological characteristics and LNR or PLNC. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors for survival. Spearman correlation analysis was used to determine the correlation between LNR and PLNC. Results We found that patients with high LNR tended to have advanced N stage, the 7th AJCC stage, and higher pathological grade, while patients with high PLNC had advanced N stage and the 7th AJCC stage. Univariate Cox regression analysis revealed that the N stage, M stage, the 7th AJCC stage, lymph-vascular invasion, LNR, and PLNC were significantly associated with prognosis. Multivariate Cox regression analysis demonstrated that LNR rather than PLNC was an independent prognostic factor for cancer-specific survival. Subgroup analysis of node-positive patients showed that LNR was associated with CSS, while PLNC was not. Conclusion LNR was a better predictor for long-term prognosis than PLNC in patients with penile squamous cell carcinoma.

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“…In studies conducted so far, older age, black race, stage IV disease, ≤1 negative lymph node, and a >31.3% lymph node ratio were significantly associated with worse survival across all prediction models in male breast cancer (BC) [1]. Age at diagnosis, tumor grade, stage, surgery, radiotherapy, estrogen (ER), and marital status have a clear impact on overall survival (OS) of male BC patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of the Neutrophil-Lymphocyte, Platelet-Lymphocyte, and Monocyte-Lymphocyte Ratios in Male Breast Cancer Patients

Huszno¹,

Kołosza²,

Mrochem-Kwarciak³

et al. 2020

Oncology

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Background:The aim of the present study was to assess the blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) as prognostic factors in male breast cancer (BC) patients. Methods: A retrospective analysis of 38 male BC patients who were treated at the Institute of Oncology (Gliwice, Poland) between January 2005 and December 2018 was performed. The prognostic value (in terms of overall survival [OS]) of the pretreatment PLR, NLR, and MLR was assessed by univariate analysis. Results: We observed a tendency towards worse OS among male BC patients with lymph node metastases (N+) (5-year OS: 43.5 vs. 73.9%; p = 0.087), a greater tumor size (T4 vs. T1 + T2) (42.0 vs. 70.5%; p = 0.061), and a negative steroid receptor status (PR-) (28.6 vs. 65.6%; p = 0.109). Patients with a family history of cancer had significantly better 5-year OS than patients without a family history of cancer (86.3 vs. 35.0%; p = 0.001). Younger male BC patients (age ≤56 years) had better 5-year OS than patients >56 years of age (82.5 vs. 42.3%; p = 0.028). The 5-year OS was lower among patients with a lower lymphocyte value (≤1.82 × 10 3 ) (29.0 vs. 75.6%; p = 0.010). There was a tendency towards worse OS among patients with a higher platelet count (>281 × 10 3 ) (4.5-year OS: 16.7 vs. 65.8%; p = 0.056). The 5-year OS was insignificantly lower in the group with NLRs >2.74 than in the group with NLRs ≤2.74 (37.5 vs. 62.8%; p = 0.078). A worse OS rate was associated with an elevated PLR (>169.1) (22.2 vs. 70.1%; p = 0.008). Similarly, there was worse OS in the group with higher MLR (>0.30) (41.8 vs. 78.3%; p = 0.025). Conclusions:The present results reveal that elevated MLRs (>0.30) and PLRs (>169.1) are associated with poor OS among male BC patients. Similarly, but insignificantly, an elevated NLR (>2.74) affected OS.

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Negative Lymph Node Count and Lymph Node Ratio Are Associated With Survival in Male Breast Cancer

Cited by 14 publications

References 57 publications

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

Examined and Positive Lymph Node Counts Are Associated with Mortality in Prostate Cancer: A Population-Based Analysis

The prognostic value of lymph node ratio in comparison to positive lymph node count in penile squamous cell carcinoma

Prognostic Value of the Neutrophil-Lymphocyte, Platelet-Lymphocyte, and Monocyte-Lymphocyte Ratios in Male Breast Cancer Patients

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