Negative pressure cavitation based ultrasound-assisted extraction of main flavonoids from Flos Sophorae Immaturus and evaluation of its extraction kinetics

Wang, Gen; Cui, Qi; Yin, Lujun; Li, Ying; Gao, Ming‐Zhu; Meng, Yao; Li, Ji; Zhang, Sun-Dong; Wang, Wei

doi:10.1016/j.seppur.2019.115805

Cited by 33 publications

(16 citation statements)

References 49 publications

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“…The efficiency of NPCE increased significantly in combination with ultra-sonication. Wang et al [167] developed a UAE method for the extraction of flavonols from Flos Sophorae immaturus combined with negative pressure cavitation (NPC-UAE). The authors reported that the NPC-UAE extraction yield for six compounds was 1.27-1.62 and 1.17-1.40 folds higher than the output of NPCE and UAE, respectively.…”

Section: Negative Pressure Cavitation Extraction (Npce)mentioning

confidence: 99%

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

et al. 2020

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Flavonoids have a broad spectrum of established positive effects on human and animal health. They find an application in medicine for disease therapy and chemoprevention, whence the interest in flavonoids increases. In addition, they are used in food and cosmetic industries as pigments and biopreservatives. Plants are an inexhaustible source of flavonoids. The most important step of plant raw material processing is extraction and isolation of target compounds. The quality of an extract and efficiency of a procedure are influenced by several factors: Plant material and pre-extracting sample preparation, type of solvent, extraction technique, physicochemical conditions, etc. The present overview discusses the common problems and key challenges of the extraction procedures and the different mechanisms for selective extraction of flavonoids from different plant sources. In summary, there is no universal extraction method and each optimized procedure is individual for the respective plants. For an extraction technique to be selective, it must combine an optimal solvent or mixture of solvents with an appropriate technique. Last but not least, its optimization is important for a variety of applications. Moreover, when the selected method needs to be standardized, it must achieve acceptable degree of repeatability and reproducibility.

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Section: Negative Pressure Cavitation Extraction (Npce)mentioning

confidence: 99%

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

et al. 2020

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“…Nevertheless, the time spent during the sonication, the solvent:sample ratio, and the solvent composition are also influential factors [ 73 , 93 ]. NPC is influenced by the solvent:sample ratio, negative pressure, and ethanol concentration [ 35 , 86 ]. However, the extraction efficiency may be improved when it is used coupled to other technologies such as the microwave, enzyme, or ultrasound, being that it is necessary to adjust the conditions of both methodologies to obtain targeted compounds [ 35 , 37 , 86 ].…”

Section: Doe: From Concept To Product Developmentmentioning

confidence: 99%

“…NPC is influenced by the solvent:sample ratio, negative pressure, and ethanol concentration [ 35 , 86 ]. However, the extraction efficiency may be improved when it is used coupled to other technologies such as the microwave, enzyme, or ultrasound, being that it is necessary to adjust the conditions of both methodologies to obtain targeted compounds [ 35 , 37 , 86 ]. Due to the fact that PLE is performed in equipment that usually sets the working pressure at 100–110 bars [ 11 , 75 ], temperature and solvent composition are the factors that exert a major effect on the evaluated responses [ 76 ].…”

Section: Doe: From Concept To Product Developmentmentioning

confidence: 99%

Application of Response Surface Methodologies to Optimize High-Added Value Products Developments: Cosmetic Formulations as an Example

et al. 2022

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In recent years, green and advanced extraction technologies have gained great interest to revalue several food by-products. This by-product revaluation is currently allowing the development of high value-added products, such as functional foods, nutraceuticals, or cosmeceuticals. Among the high valued-added products, cosmeceuticals are innovative cosmetic formulations which have incorporated bioactive natural ingredients providing multiple benefits on skin health. In this context, the extraction techniques are an important step during the elaboration of cosmetic ingredients since they represent the beginning of the formulation process and have a great influence on the quality of the final product. Indeed, these technologies are claimed as efficient methods to retrieve bioactive compounds from natural sources in terms of resource utilization, environmental impact, and costs. This review offers a summary of the most-used green and advanced methodologies to obtain cosmetic ingredients with the maximum performance of these extraction techniques. Response surface methodologies may be applied to enhance the optimization processes, providing a simple way to understand the extraction process as well as to reach the optimum conditions to increase the extraction efficiency. The combination of both assumes an economic improvement to attain high value products that may be applied to develop functional ingredients for cosmetics purposes.

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“…Meanwhile, the highest TAC from columella (1.52 mg/g DW) was obtained with 10 min of extraction, 40% amplitude, and 0.4 s of pulse-cycle. The effect of UAE on the extraction of ACGs is discussed as follows: the application of ultrasonic waves had mechanical and thermal effects producing cavitation in the solvent; the microbubbles interacted with the vegetal cells and modify their structure by breaking down the cell walls and/or increasing the size of cell pores, resulting in a faster dissolution of the bioactive compounds in the solvent [21][22][23]. On the other hand, the differences of the UAE conditions for extracting ACGs also depend on the structural chemical composition of each raw material and the physical-mechanical phenomenon generated by each UAE combination.…”

Section: Effect Of Ultrasound-assisted Extraction (Uae) On the Total mentioning

confidence: 99%

Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology

et al. 2020

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The soursop fruit or Annona muricata (A. muricata) fruit is recognized by its bioactive compounds and acetogenins (ACG) are among the most important. The effect of ACGs, with greater importance in health, is that they present anti-tumor activity; however, the methods of extraction of ACGs are very slow and with a high expenditure of solvents. To our knowledge, there is no report of an optimal method for the extraction of acetogenins from the Annonaceae family by ultrasound-assisted extraction (UAE); therefore, the aim was to find the best UEA conditions of acetogenins from A. muricata fruit (peel, pulp, seed, and columella) by using response surface methodology. The effect of amplitude (40%, 70%, and 100%), time (5, 10, and 15 min), and pulse-cycle (0.4, 0.7, and 1 s) of ultrasound at 24 kHz was evaluated on the total acetogenin content (TAC). Optimal extraction conditions of acetogenins (ACGs) with UEA were compared with the extraction of ACGs by maceration. The optimal UEA conditions in the A. muricata pulp and by-products were dependent on each raw material. The highest TAC was found in the seed (13.01 mg/g dry weight (DW)), followed by the peel (1.69 mg/g DW), the pulp (1.67 mg/g DW), and columella (1.52 mg/g DW). The experimental TAC correlated well with the model (Adjusted R2 with values between 0.88 and 0.97). The highest effectiveness in ACG extraction was obtained in seeds and peels using UEA compared to extraction by maceration (993% and 650%, respectively). The results showed that A. muricata by-products are an important source of ACGs and that UAE could be a viable alternative, with high potential for large-scale extraction.

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Negative pressure cavitation based ultrasound-assisted extraction of main flavonoids from Flos Sophorae Immaturus and evaluation of its extraction kinetics

Cited by 33 publications

References 49 publications

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

Selectivity of Current Extraction Techniques for Flavonoids from Plant Materials

Application of Response Surface Methodologies to Optimize High-Added Value Products Developments: Cosmetic Formulations as an Example

Ultrasound-Assisted Extraction of Total Acetogenins from the Soursop Fruit by Response Surface Methodology

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